L'équipe Duharcourt a publié un nouvel article dans Nucleic Acids Research : The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium   Résumé : Ciliates undergo developmentally programmed genome elimination, in which small RNAs direct the removal of transposable elements (TEs) during the development of the somatic nucleus. Twenty-five nucleotide scanRNAs (scnRNAs) are produced from…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans PNAS : HIV-1 budding requires cortical actin disassembly by the oxidoreductase MICAL1   Résumé : Many enveloped viruses bud from the plasma membrane that is tightly associated with a dense and thick actin cortex. This actin network represents a significant challenge for membrane deformation and scission, and…

L'équipe Minc a publié un article de méthode dans Methods in Molecular Biology :  Analysis of Cell Wall Mechanics in Fission Yeast   Résumé : The growth and shape of fungal cells, such as fission yeast, are strongly constrained by the mechanics of their cell wall (CW). The cell wall encases the plasma membrane and defines instantaneous cell shapes…

L'équipe Dumont a contribué à un article publié dans microPublication Biology : Cell type-specific regulation by different cytokinetic pathways in the early embryo Résumé : Cytokinesis, the physical division of one cell into two, is typically assumed to use the same molecular process across animal cells. However, regulation of cell division can vary significantly among different cell…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans ACS Chemical Biology : Bioorthogonal Monomycolate of Trehalose Disclosed the O-Mycoloylation of Mycoloyltransferases and Other Cell Envelope Proteins in C. glutamicum   Résumé : Protein mycoloylation is a recently identified unusual post-translational modification (PTM) exclusively observed in Mycobacteriales, an order of bacteria that includes several human pathogens.…

L'équipe Courtier a publié un nouvel article dans Evolutionary Biology : A scenario for an evolutionary selection of ageing Résumé : Signs of ageing become apparent only late in life, after organismal development is finalized. Ageing, most notably, decreases an individual’s fitness. As such, it is most commonly perceived as a non-adaptive force of evolution and…

Isabelle le Parco, ainsi que la plateforme qu'elle dirige, a contribué a la publication d'un article dans Communications biology : Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation Résumé : Intestinal smooth muscle differentiation is a complex physico-biological process involving several different pathways. Here, we investigate the properties of Ca2+ waves…

L'équipe Veitia a publié un nouvel article dans Trends in Genetics : Emerging links between phase separation and transcription factor haploinsufficiency   Résumé : Recent studies have addressed the relevance of phase separation, by which membrane-less compartments are formed within the nucleus, to understand the impact of genetic variants. They highlight unsuspected links between phase separation and haploinsufficiency…

L'équipe Greenberg a publié un nouvel article dans Nature structural & Molecular biology: DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency Résumé : In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at CpG-rich regions. As mouse embryonic stem cells exit…

L'équipe Grange / Geigl a publié un nouvel article dans Molecular biology and evolution : The Population History of Domestic Sheep Revealed by Paleogenomes   Résumé : Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication first took place in Southwest Asia, although much remains unresolved about the precise…