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Raote Lab – TUG protein acts through a disordered region to organize the early secretory pathway

L'équipe Raote a contribué à la publication d'un nouvel article dans Nature communications : TUG protein acts through a disordered region to organize the early secretory pathway Résumé : The Endoplasmic Reticulum (ER)-Golgi Intermediate Compartment (ERGIC) is a network of tubules and vesicles known for producing COPI vesicles and receiving COPII vesicles from the ER. Much about…

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Palancade Lab / ProtéoSeine – Cellular imbalance of specific RNA binding proteins associates with harmful R-loops

L'équipe Palancade et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans PLOS Genetics : Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Abstract : Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome…

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Guichet Lab – Sheltered load in fungal mating-type chromosomes revealed by fitness experiments

L'équipe Guichet a contribué à une nouvelle publication dans Journal of Evolutionary Biology : Sheltered load in fungal mating-type chromosomes revealed by fitness experiments Résumé : Sex chromosomes and mating-type chromosomes can carry large regions with suppressed recombination. As a result of a lower efficacy of selection, recessive deleterious mutations are expected to accumulate in these non-recombining…

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Greenberg Lab – PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Epigenetics : PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation   Résumé : Genomic imprinting is the parent-of-origin specific monoallelic expression of genes that result from complex epigenetic interactions. It is often achieved by monoallelic 5-methylcytosine, resulting in the formation of differentially methylated regions…

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Ladoux/Mège Lab – MSC Lab – Institut Cochin The enteric nervous system is 10 times stiffer than the brain

L'équipe Ladoux-Mège, le laboratoire MSC et l'Institut Cochin ont publié en collaboration un nouvel article dans Biophysical Journal : The enteric nervous system is 10 times stiffer than the brain L’intestin est le seul organe de notre corps doté d’une innervation quasi-autonome, le système nerveux entérique, appelé communément le « second cerveau ». Le cerveau et à la…

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Romet-Lemonne/Jégou Lab – Continuous self-repair protects vimentin intermediate filaments from fragmentation

L'équipe Romet-Lemonne/Jégou a publié une nouvelle publication dans PNAS : Continuous self-repair protects vimentin intermediate filaments from fragmentation Résumé : Intermediate filaments are key regulators of cell mechanics. Vimentin, a type of intermediate filament expressed in mesenchymal cells and involved in migration, forms a dense network in the cytoplasm that is constantly remodeling through filament transport, elongation/shortening,…

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Ladoux/Mege Lab – Osmotic pressure induces unexpected relaxation of contractile 3D microtissue

L'équipe Ladoux/Mège a contribué à la publication d'un nouvel article dans The European Physical Journal E : Osmotic pressure induces unexpected relaxation of contractile 3D microtissue   Résumé : Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…

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La Science, CQFD, avec Eva-Maria Geigl

Retrouverez l'intervention de Eva-Maria Geigl dans un podcast diffusé dans l'émissions La Science, CQFD : Domestication : le jeu du chat et de l'Homme Avec sa popularité grandissante, le chat est devenu un animal de compagnie très prisé. Les premières traces de sa cohabitation avec l’humain remontent au Néolithique. Comment étudier son long processus de domestication ?…

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Minc Lab – Cell division: Size-scaling cytoplasmic flows transport chromosomes to the right spot

L'équipe Minc a publié un nouvel article dans Current Biology : Cell division: Size-scaling cytoplasmic flows transport chromosomes to the right spot   Résumé : Early embryos undergo rounds of division, producing cells of reducing sizes that must scale the distance chromosomes segregate. A new study shows that this scaling results from a cell-size-dependent dampening of cytoplasmic flows…

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Minc Lab – Dynamic clamping induces rotation-to-beating transition of pinned filaments in gliding assays

L'équipe Minc a publié un nouvel article dans Journal of the royal society interface : Dynamic clamping induces rotation-to-beating transition of pinned filaments in gliding assays Résumé : We used numerical simulations to investigate how properties of motor proteins control the dynamical behaviour of driven flexible filaments. A filament on top of a patch of anchored motor proteins…

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