Skip to content Skip to footer

ProtéoSeine/ImagoSeine – Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy

Les plateformes ProtéoSeine et ImagoSeine ont contribué à la publication d'un article dans Nature communications : Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy Résumé Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp. have evolved…

Read More

Gazave Lab – Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate Ciona

L'équipe Gazave a publié un nouvel article dans Scientific report : Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate Ciona Résumé Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis…

Read More

Conduit Lab – Building the centrosome: PLK-1 controls multimerization of SPD-5

L'équipe Conduit a publié un spotlight dans Journal of Cell Biology : Building the centrosome: PLK-1 controls multimerization of SPD-5   Introduction : Centrosome maturation relies on the assembly of an underlying molecular scaffold. In this issue of JCB, Rios et al. (https://doi.org/10.1083/jcb.202306142) use cross-linking mass spectrometry to reveal how PLK-1 phosphorylation promotes intermolecular SPD-5 self-association that is…

Read More

Jackson/Verbavatz Lab – The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

L'équipe Jackson/Verbavatz a publié un nouvel article dans eLife : The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions   Résumé : Cell motility processes highly depend on the membrane distribution of Phosphoinositides, giving rise to cytoskeleton reshaping and membrane trafficking events. Membrane contact sites serve as platforms for…

Read More

JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development

Un nouvel article a été publié dans Nature Communications : JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development Cette étude est le fruit d'une collaboration entre des scientifiques l’Institut de biologie intégrative de la cellule (université Paris-Saclay) et de l'Institut Jacques Monod (Konstantinides Lab, Minc Lab, Guichet Lab).   Résumé : The number of…

Read More

Pintard Lab – Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans

L'équipe Pintard a publié un nouvel article dans Journal of Cell Biology : Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans   Résumé : Microtubule-severing enzymes (MSEs), such as Katanin, Spastin, and Fidgetin play essential roles in cell division and neurogenesis. They damage the microtubule (MT) lattice, which can either destroy or amplify…

Read More

Courtier Lab – Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences

L'équipe Courtier a récemment publié un nouvel article dans BMC Ecology and Evolution : Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences Résumé : Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood.…

Read More

Wassmann Lab – Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast

L'équipe Wassmann a publié un nouvel article dans EMBO : Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast   Résumé : Exit from mitosis is brought about by dramatic changes in the phosphoproteome landscape. A drop in Cyclin-dependent kinase (Cdk) activity, the master regulatory kinase, and activation of counteracting phosphatases such as Cdc14…

Read More

Romet-Lemonne/Jégou Lab – Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament   Résumé : Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration…

Read More