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JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development

Les dernières publications27 février 2024
Un nouvel article a été publié dans Nature Communications : JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development Cette étude est le fruit d'une collaboration entre des scientifiques l’Institut de biologie intégrative de la cellule (université Paris-Saclay) et de l'Institut Jacques Monod (Konstantinides Lab, Minc Lab, Guichet Lab).   Résumé : The number of…

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Pintard Lab – Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans

Actualités, Les dernières publications13 février 2024
L'équipe Pintard a publié un nouvel article dans Journal of Cell Biology : Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans   Résumé : Microtubule-severing enzymes (MSEs), such as Katanin, Spastin, and Fidgetin play essential roles in cell division and neurogenesis. They damage the microtubule (MT) lattice, which can either destroy or amplify…

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Courtier Lab – Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences

Actualités, Les dernières publications13 février 2024
L'équipe Courtier a récemment publié un nouvel article dans BMC Ecology and Evolution : Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences Résumé : Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood.…

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Wassmann Lab – Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast

Actualités, Les dernières publications13 février 2024
L'équipe Wassmann a publié un nouvel article dans EMBO : Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast   Résumé : Exit from mitosis is brought about by dramatic changes in the phosphoproteome landscape. A drop in Cyclin-dependent kinase (Cdk) activity, the master regulatory kinase, and activation of counteracting phosphatases such as Cdc14…

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Romet-Lemonne/Jégou Lab – Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

Actualités, Les dernières publications29 janvier 2024
L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament   Résumé : Regulation of the assembly and turnover of branched actin filament networks nucleated by the Arp2/3 complex is essential during many cellular processes, including cell migration…

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Guichet Lab – The Importance of the Position of the Nucleus in Drosophila Oocyte Development

Actualités, Les dernières publications29 janvier 2024
L'équipe Guichet a publié un nouvel article dans Cells : The Importance of the Position of the Nucleus in Drosophila  Oocyte Development Résumé : Oogenesis is a developmental process leading to the formation of an oocyte, a haploid gamete, which upon fertilisation and sperm entry allows the male and the female pronuclei to fuse and give rise to…

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Romet-Lemonne/Jégou Lab – Regeneration of actin filament branches from the same Arp2/3 complex

Actualités, Les dernières publications29 janvier 2024
L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans Science Advances : Regeneration of actin filament branches from the same Arp2/3 complex Résumé : Branched actin filaments are found in many key cellular structures. Branches are nucleated by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to the side of preexisting “mother” filaments. Over time,…

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Palancade Lab – On the edge: how nuclear pore complexes rule genome stability

Actualités, Les dernières publications18 janvier 2024
L'équipe Palancade a publié une nouvelle review dans Current Opinion in Genetics & Development : On the edge: how nuclear pore complexes rule genome stability   Résumé : Nuclear organization has emerged as a critical layer in the coordination of DNA repair activities. Distinct types of DNA lesions have notably been shown to relocate at the vicinity…

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Greenberg lab – DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation

Actualités, Les dernières publications5 janvier 2024
L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nature Structural & Molecular biology : DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation   Résumé : As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation levels. During this transition, the…

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