L'équipe Pintard a publié un nouvel article dans The Journal of Cell biology : Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis Résumé : Microtubule-severing enzymes are evolutionarily conserved AAA-ATPases that sever microtubules, thereby regulating diverse microtubule-dependent cellular processes. How these enzymes couple Microtubule binding with ATP hydrolysis to trigger microtubule-remodeling remains poorly understood.…

L'équipe Veitia a publié un nouvel article dans Molecular & Cellular Proteomics : Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model.   Résumé : Background Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. This study…

L'équipe Ladoux/Mège a publié un nouvel article dans PNAS : Regulation of epithelial tissue homeostasis by active transepithelial transport Résumé : Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties of extracellular matrix, a interesting mechanobiological paradigm highlights the role of…

L'équipe Ladoux/Mege et Jackson/Verbavatz ont publié un nouvel article "news and views" dans Nature : ‘Memory foam’ skeleton in cells helps them to navigate d'Alessandro J, Heuzé ML. 'Memory foam' skeleton in cells helps them to navigate. Nature. 2025 Nov;647(8088):42-44. doi: 10.1038/d41586-025-03448-z. PMID: 41184472.

L'équipe Ribes / Nedelec a publié un nouvel article dans PLOS Biology : Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks   Résumé : Understanding how transcription factors regulate organized cellular diversity in developing tissues remains a major challenge due to their pleiotropic functions. We addressed this by monitoring and…

L'équipe Dumont a publié un nouvel article dans Journal of Cell Biology : Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation L'équipe Minc de l'Institut Jacques Monod a également contribué à cet article. Résumé : Chromosome segregation during anaphase occurs through two mechanistically distinct processes: anaphase A, in which chromosomes move toward spindle poles, and…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Nature metabolism : Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation Résumé : The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut microbiota-related metabolites to…

L'équipe Duharcourt a publié un nouvel article dans Nucleic Acids Research : A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium La plateforme ProtéoSeine de l'Institut Jacques Monod a également contribué à cet article. Résumé : To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity…