L'équipe Dumont a publié un nouvel article dans Journal of Cell Biology : Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation L'équipe Minc de l'Institut Jacques Monod a également contribué à cet article. Résumé : Chromosome segregation during anaphase occurs through two mechanistically distinct processes: anaphase A, in which chromosomes move toward spindle poles, and…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Nature metabolism : Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation Résumé : The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut microbiota-related metabolites to…

L'équipe Duharcourt a publié un nouvel article dans Nucleic Acids Research : A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium La plateforme ProtéoSeine de l'Institut Jacques Monod a également contribué à cet article. Résumé : To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity…

L'équipe Borghi a publié un nouvel article dans PLoS Computational Biology : Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy   Résumé : Segmentation and detection of biological objects in fluorescence microscopy is of paramount importance in cell imaging. Deep learning approaches have recently shown promise to advance, automatize and accelerate analysis. However, most of…

L'équipe Léon a publié, en collaboration avec la plateforme ProtéoSeine, un nouvel article dans Plos Genetics : A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition   Résumé : The yeast Saccharomyces cerevisiae thrives in sugar-rich environments by rapidly consuming glucose and favoring alcoholic fermentation. This strategy is tightly regulated by the glucose…

La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Communication Biology : Myocardial disarray drives metabolic inefficiency in human cardiomyocytes   Résumé : Adult cardiomyocytes are embedded within a highly organized myocardial microenvironment that imposes critical geometric cues essential for the alignment and distribution of organelles and the shaping of their unique, rectangular cellular morphology.…

L'équipe Raote a contribué à la publication d'un nouvel article dans Nature reviews molecular cell biology : Towards a unified framework for the function of endoplasmic reticulum exit sites Résumé : Endoplasmic reticulum exit sites (ERES) are specialized, ribosome-free ER subdomains that serve as dynamic portals for COPII-mediated export of proteins from the ER. Beyond…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Cell Host & Microbe : Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation   Résumé : Cadaverine is a polyamine produced by the gut microbiota with links to health and disease, notably inflammatory bowel disease (IBD). Here, we show that cadaverine shapes…

L'équipe Greenberg a publié une nouvelle revue dans Plos Genetics : Epigenetic relay: Polycomb-directed DNA methylation in mammalian development Résumé : In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of promoter 5-cytosine DNA methylation (5meC). Early mammalian development, however, is…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers Résumé : Branched actin networks nucleated by the Arp2/3 complex have critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90-family proteins, Arp2/3 nucleates linear actin…