Un nouvel article publié dans Cancers : Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death Abstract Auranofin (Ridaura®, AUF) is a gold complex originally approved as an antirheumatic agent that has emerged as a potential candidate for multiple repurposed therapies. The best-studied anticancer mechanism of AUF is the inhibition of thioredoxin reductase (TrxR). However,…

L'équipe Wassmann vient de publier un nouvel article dans Developmental Cell: Cyclin B3 implements timely vertebrate oocyte arrest for fertilization Summary To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II until sperm entry. Emi2 is essential to keep oocytes arrested until fertilization. However, how this arrest is implemented exclusively in…

L'équipe Wassmann vient de publier un nouvel article dans Star Protocols! Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor Summary Here, we describe a biosensor to assess meiotic cohesin subunit Rec8 cleavage in mouse oocytes. We detail oocyte collection and microinjection of the mRNA expressing…

L'équipe Ladoux/Mège vient de publier un nouvel article dans Science Advances : The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces   Abstract Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship with substrate curvatures are intimately linked to spontaneous…

L'équipe Plessis vient de publier dans eLife un nouvel article : High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened Abstract The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial…