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Microphysio24: From organoids to organs-on-chips

Actualités, Les dernières actualités6 mai 2024
Microphysio24: From organoids to organs-on-chips The 2nd edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip"  will take place at the CNRS center in Cargèse (www.iesc.univ-corse.fr) from September 23rd to September 27th, 2024. It is becoming increasingly clear that even the best in vivo models such as genetically-modified mouse models or orthotopic patient-derived xenografts cannot recapitulate the full complexity of human…

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ImagoSeine – CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT

Actualités, Les dernières publications3 mai 2024
La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Circulation : CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT   Résumé : BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug…

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Dumont Lab – Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane

Actualités, Les dernières publications3 mai 2024
L'équipe Dumont a contribué à la publication d'un nouvel article dans Molecular Biology of Cell : Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane   Résumé : Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of…

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Non classé30 avril 2024
Responsables Benoit LADOUX , Chercheur, LADOUX/MEGE LAB +33 (0)1 57 27 80 71, bureau 142B Rene-Marc MEGE , Chercheur, LADOUX/MEGE LAB +33 (0)1 57 27 80 67, bureau 142B Membres Lucas ANGER , Doctorant, LADOUX/MEGE LAB +33 (0)1 57 27 80 67, bureau 142B Gregory ARKOWITZ , Doctorant, LADOUX/MEGE…

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Ribes Lab – Non-Mammalian Models for Understanding Neurological Defects in RASopathies

Actualités, Les dernières publications29 avril 2024
L'équipe Ribes a contribué à la publication d'une revue dans Biomedicines : Non-Mammalian Models for Understanding Neurological Defects in RASopathies   Résumé : RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders. Afflicting approximately one in a thousand newborns, RASopathies manifest…

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Jackson/Verbavatz Lab – Staying on track – Keeping things running in a high-end scientific imaging core facility

Actualités, Les dernières publications26 avril 2024
L'équipe Jackson/Verbavatz a contribué à la publication d'un article thématique : Staying on track – Keeping things running in a high-end scientific imaging core facility   Résumé : Modern life science research is a collaborative effort. Few research groups can single-handedly support the necessary equipment, expertise and personnel needed for the ever-expanding portfolio of technologies that are required…

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Raote Lab – TANGO1 inhibitors reduce collagen secretion and limit tissue scarring

Actualités, Les dernières publications26 avril 2024
L'équipe Raote a publié un nouvel article dans Nature communications : TANGO1 inhibitors reduce collagen secretion and limit tissue scarring   Résumé : Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies are lacking. A promising approach…

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Séminaire IJM – Christophe Leterrier – 31/05/2024

Actualités22 avril 2024
Invité par l'équipe Ladoux/Mège, Christophe Leterrier (Aix Marseille Université, CNRS, INP, NeuroCyto Lab) présentera un séminaire de l'Institut Jacques Monod sur le thème : The axonal cytoskeleton down to the nanoscale   Résumé : The intricate arborization and molecular identity of axons is maintained for decades, but must also continuously adapt to changes in the environment and modulate…

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Duharcourt Lab – Small-RNA-guided histone modifications and somatic genome elimination in ciliates

Actualités, Les dernières publications16 avril 2024
L'équipe Duharcourt a publié une nouvelle revue dans WIREs RNA : Small-RNA-guided histone modifications and somatic genome elimination in ciliates   Résumé : Transposable elements and other repeats are repressed by small-RNA-guided histone modifications in fungi, plants and animals. The specificity of silencing is achieved through base-pairing of small RNAs corresponding to the these genomic loci to nascent…

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Conduit Lab – γ-TuRCs and Augmin are required for the development of highly branched dendritic arbors in Drosophila

Actualités, Les dernières publications15 avril 2024
L'équipe Conduit a publié un nouvel article dans Journal of Cell Science : γ-TuRCs and Augmin are required for the development of highly branched dendritic arbors in Drosophila   Résumé : Microtubules are nucleated by γ-tubulin ring complexes (γ-TuRCs) and are essential for neuronal development. Nevertheless, γ-TuRC depletion has been reported to perturb only higher-order branching in elaborated Drosophila larval…

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