Fetal Programming by Methyl Donor Deficiency Produces Pathological Remodeling of the Ascending Aorta

Balint B, Hergalan S, Camadro JM, Blaise S, Vanalderwiert L, Lignières L, Guéant-Rodriguez RM,  Guéant JL.

Arterioscler Thromb Vasc Biol. 2021 Apr 8;ATVBAHA120315587 doi: 10.1161/ATVBAHA.120.315587.

Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis

Lautier O, Penzo A,  Rouvière J.O, Chevreux G,  Collet L, Loïodice I, Taddei A,  Devaux  F,  Collart MA, Palancade B.

Mol Cell. 2021 Apr 4;S1097-2765(21)00225-2. doi: 10.1016/j.molcel.2021.03.030.

The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division. 

Lemonnier T, Daldello EM, Poulhe R, Le T, Miot M, Lignières L, Jessus C, Dupré A.

Nat Commun. 2021 Mar 23;12(1):1837. doi: 10.1038/s41467-021-22124-0. PMID: 33758202

Novel Insights into Quantitative Proteomics from an Innovative Bottom-Up Simple Light Isotope Metabolic (bSLIM) Labeling Data Processing Strategy. 

Sénécaut N, Alves G, Weisser H, Lignières LTerrier S, Yang-Crosson L, Poulain P, Lelandais G, Yu YK, Camadro JM.

J Proteome Res. 2021 Mar 5;20(3):1476-1487. doi: 10.1021/acs.jproteome.0c00478. Epub 2021 Feb 11. PMID: 33573382

Isoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens. 

Darrigrand R, Pierson A, Rouillon M, Renko D, Boulpicante M, Bouyssié D, Mouton-Barbosa E, Marcoux J, Garcia C, Ghosh M, Alami M, Apcher S.

Commun Biol. 2021 Mar 1;4(1):269. doi: 10.1038/s42003-021-01801-2. PMID: 33649389

Interactions of Viral Proteins from Pathogenic and Low or Non-Pathogenic Orthohantaviruses with Human Type I Interferon Signaling. 

Gallo G, Caignard G, Badonnel K, Chevreux GTerrier S, Szemiel A, Roman-Sosa G, Binder F, Gu Q, Da Silva Filipe A, Ulrich RG, Kohl A, Vitour D, Tordo N, Ermonval M.

Viruses. 2021 Jan 19;13(1):140. doi: 10.3390/v13010140. PMID: 33478127

Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells. 

Ribeiro-Parenti L, Jarry AC, Cavin JB, Willemetz A, Le Beyec J, Sannier A, Benadda S, Pelletier AL, Hourseau M, Léger TMorlet B, Couvelard A, Anini Y, Msika S, Marmuse JP, Ledoux S, Le Gall M, Bado A.

Nat Commun. 2021 Jan 4;12(1):110. doi: 10.1038/s41467-020-20301-1. PMID: 33397977


Singular manifolds of proteomic drivers to model the evolution of inflammatory bowel disease status. 

Morilla I, Léger T, Marah A, Pic I, Zaag H, Ogier-Denis E. Sci Rep. 2020 Nov 4;10(1):19066. doi: 10.1038/s41598-020-76011-7. PMID: 33149233

The adaptive response to iron involves changes in energetic strategies in the pathogen Candida albicans. 

Duval C, Macabiou C, Garcia C, Lesuisse E, Camadro JM, Auchère F.

Microbiologyopen. 2020 Feb;9(2):e970. doi: 10.1002/mbo3.970. Epub 2019 Dec 1. PMID: 31788966


The Interactome analysis of the Respiratory Syncytial Virus protein M2-1 suggests a new role in viral mRNA metabolism post-transcription. 

Bouillier C, Cosentino G, Léger T, Rincheval V, Richard CA, Desquesnes A, Sitterlin D, Blouquit-Laye S, Eléouët JF, Gault E, Rameix-Welti MA.

Sci Rep. 2019 Oct 24;9(1):15258. doi: 10.1038/s41598-019-51746-0. PMID: 31649314

Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating. 

Fernandez J, Machado AK, Lyonnais S, Chamontin C, Gärtner K, Léger T, Henriquet C, Garcia C, Portilho DM, Pugnière M, Chaloin L, Muriaux D, Yamauchi Y, Blaise M, Nisole S, Arhel NJ.

Nat Microbiol. 2019 Nov;4(11):1840-1850. doi: 10.1038/s41564-019-0575-6. Epub 2019 Oct 14. PMID: 31611641

LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses. 

Sanchez David RY, Combredet C, Najburg V, Millot GA, Beauclair G, Schwikowski B, Léger T, Camadro JM, Jacob Y, Bellalou J, Jouvenet N, Tangy F, Komarova AV.

Sci Signal. 2019 Oct 1;12(601):eaar3993. doi: 10.1126/scisignal.aar3993. PMID: 31575732

Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death. 

El Banna N, Hatem E, Heneman-Masurel A, Léger T, Baïlle D, Vernis L, Garcia C, Martineau S, Dupuy C, Vagner S, Camadro JM, Huang ME.

Redox Biol. 2019 Sep;26:101290. doi: 10.1016/j.redox.2019.101290. Epub 2019 Aug 2. PMID: 31412312

Copper and iron metabolism in Ostreococcus tauri – the role of phytotransferrin, plastocyanin and a chloroplast copper-transporting ATPase. 

Scheiber IF, Pilátová J, Malych R, Kotabova E, Krijt M, Vyoral D, Mach J, Léger T, Camadro JM, Prášil O, Lesuisse E, Sutak R.

Metallomics. 2019 Oct 16;11(10):1657-1666. doi: 10.1039/c9mt00078j. PMID: 31380866

Label-free quantitative proteomics in Candida yeast species: technical and biological replicates to assess data reproducibility. 

Lelandais G, Denecker T, Garcia C, Danila N, Léger T, Camadro JM.

BMC Res Notes. 2019 Aug 1;12(1):470. doi: 10.1186/s13104-019-4505-8. PMID: 31370875

T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide. 

Nian Q, Berthelet J, Zhang W, Bui LC, Liu R, Xu X, Duval R, Ganesan S, Leger T, Chomienne C, Busi F, Guidez F, Dupret JM, Rodrigues Lima F.

Mol Pharmacol. 2019 Aug;96(2):297-306. doi: 10.1124/mol.119.116319. Epub 2019 Jun 20. PMID: 31221825

Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities. 

Massarweh A, Bosco M, Chantret I, Léger T, Jamal L, Roper DI, Dowson CG, Busca P, Bouhss A, Gravier-Pelletier C, Moore SEH.

Molecules. 2019 Jun 6;24(11):2135. doi: 10.3390/molecules24112135. PMID: 31174247

Novel Function of Bluetongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling Pathway. 

Kundlacz C, Pourcelot M, Fablet A, Amaral Da Silva Moraes R, Léger TMorlet B, Viarouge C, Sailleau C, Turpaud M, Gorlier A, Breard E, Lecollinet S, van Rijn PA, Zientara S, Vitour D, Caignard G.

J Virol. 2019 Jul 30;93(16):e00336-19. doi: 10.1128/JVI.00336-19. Print 2019 Aug 15. PMID: 31167915

Adsorption of Proteins on m-CPPD and Urate Crystals Inhibits Crystal-induced Cell Responses: Study on Albumin-crystal Interaction. 

Renaudin F, Sarda S, Campillo-Gimenez L, Séverac C, Léger T, Charvillat C, Rey C, Lioté F, Camadro JM, Ea HK, Combes C.

J Funct Biomater. 2019 Apr 25;10(2):18. doi: 10.3390/jfb10020018. PMID: 31027151

High-throughput Exploration of the Network Dependent on AKT1 in Mouse Ovarian Granulosa Cells. 

Elzaiat M, Herman L, Legois B, Léger T, Todeschini AL, Veitia RA.

Mol Cell Proteomics. 2019 Jul;18(7):1307-1319. doi: 10.1074/mcp.RA119.0014613. Epub 2019 Apr 16. PMID: 30992313


Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse. 

Obino D, Fetler L, Soza A, Malbec O, Saez JJ, Labarca M, Oyanadel C, Del Valle Batalla F, Goles N, Chikina A, Lankar D, Segovia-Miranda F, Garcia CLéger T, Gonzalez A, Espéli M, Lennon-Duménil AM, Yuseff MI.

Cell Rep. 2018 Dec 11;25(11):3110-3122.e6. doi: 10.1016/j.celrep.2018.11.052. PMID: 30540943

Proteomic Landscape of Cholangiocarcinomas Reveals Three Different Subgroups According to Their Localization and the Aspect of Non-Tumor Liver. 

Le Faouder J, Gigante E, Léger T, Albuquerque M, Beaufrère A, Soubrane O, Dokmak S, Camadro JM, Cros J, Paradis V.

Proteomics Clin Appl. 2019 Jan;13(1):e1800128. doi: 10.1002/prca.201800128. Epub 2018 Dec 19. PMID: 30520266

Proteome characterization in various biological fluids of Trypanosoma brucei gambiense-infected subjects. 

Bonnet J, Garcia CLeger T, Couquet MP, Vignoles P, Vatunga G, Ndung’u J, Boudot C, Bisser S, Courtioux B.

J Proteomics. 2019 Mar 30;196:150-161. doi: 10.1016/j.jprot.2018.11.005. Epub 2018 Nov 7. PMID: 30414516

AAV-8 and AAV-9 Vectors Cooperate with Serum Proteins Differently Than AAV-1 and AAV-6. 

Denard J, Rouillon J, Leger TGarcia C, Lambert MP, Griffith G, Jenny C, Camadro JM, Garcia L, Svinartchouk F.

Mol Ther Methods Clin Dev. 2018 Aug 8;10:291-302. doi: 10.1016/j.omtm.2018.08.001. eCollection 2018 Sep 21. PMID: 30155509

Quantitative proteomics in Friedreich’s ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis. 

Télot L, Rousseau E, Lesuisse E, Garcia CMorlet BLéger T, Camadro JM, Serre V.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):997-1009. doi: 10.1016/j.bbadis.2018.01.010. Epub 2018 Jan 9. PMID: 29329987


A Simple Light Isotope Metabolic Labeling (SLIM-labeling) Strategy: A Powerful Tool to Address the Dynamics of Proteome Variations In Vivo

Léger TGarcia CCollomb L, Camadro JM.

Mol Cell Proteomics. 2017 Nov;16(11):2017-2031. doi: 10.1074/mcp.M117.066936. Epub 2017 Aug 18. PMID: 28821603

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs. 

Richarme G, Liu C, Mihoub M, Abdallah J, Leger T, Joly N, Liebart JC, Jurkunas UV, Nadal M, Bouloc P, Dairou J, Lamouri A.

Science. 2017 Jul 14;357(6347):208-211. doi: 10.1126/science.aag1095. Epub 2017 Jun 8. PMID: 28596309

Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis. 

Hovsepian J, Defenouillère Q, Albanèse V, Váchová L, Garcia C, Palková Z, Léon S.

J Cell Biol. 2017 Jun 5;216(6):1811-1831. doi: 10.1083/jcb.201610094. Epub 2017 May 3. PMID: 28468835

Modulation of the specific glutathionylation of mitochondrial proteins in the yeast Saccharomyces cerevisiae under basal and stress conditions. 

Gergondey R, Garcia C, Marchand CH, Lemaire SD, Camadro JM, Auchère F.

Biochem J. 2017 Mar 15;474(7):1175-1193. doi: 10.1042/BCJ20160927. PMID: 28167699

Metabolomic and proteomic investigations of impacts of titanium dioxide nanoparticles on Escherichia coli. 

Planchon M, Léger T, Spalla O, Huber G, Ferrari R.

PLoS One. 2017 Jun 1;12(6):e0178437. doi: 10.1371/journal.pone.0178437. eCollection 2017. PMID: 28570583

Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia. 

Boukpessi T, Hoac B, Coyac BR, Leger TGarcia C, Wicart P, Whyte MP, Glorieux FH, Linglart A, Chaussain C, McKee MD.

Bone. 2017 Feb;95:151-161. doi: 10.1016/j.bone.2016.11.019. Epub 2016 Nov 21. PMID: 27884786


Tma108, a putative M1 aminopeptidase, is a specific nascent chain-associated protein in Saccharomyces cerevisiae. 

Delaveau T, Davoine D, Jolly A, Vallot A, Rouvière JO, Gerber A, Brochet S, Plessis M, Roquigny R, Merhej J, Leger TGarcia C, Lelandais G, Laine E, Palancade B, Devaux F, Garcia M.

Nucleic Acids Res. 2016 Oct 14;44(18):8826-8841. doi: 10.1093/nar/gkw732. Epub 2016 Aug 31. PMID: 27580715

Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase. 

Mathieu C, Li de la Sierra-Gallay I, Duval R, Xu X, Cocaign A, Léger T, Woffendin G, Camadro JM, Etchebest C, Haouz A, Dupret JM, Rodrigues-Lima F.

J Biol Chem. 2016 Aug 26;291(35):18072-83. doi: 10.1074/jbc.M116.738898. Epub 2016 Jul 8. PMID: 27402852

Ostreococcus tauri is a new model green alga for studying iron metabolism in eukaryotic phytoplankton. 

Lelandais G, Scheiber I, Paz-Yepes J, Lozano JC, Botebol H, Pilátová J, Žárský V, Léger T, Blaiseau PL, Bowler C, Bouget FY, Camadro JM, Sutak R, Lesuisse E.

BMC Genomics. 2016 May 3;17:319. doi: 10.1186/s12864-016-2666-6. PMID: 27142620

The Metacaspase (Mca1p) Restricts O-glycosylation During Farnesol-induced Apoptosis in Candida albicans. 

Léger TGarcia C, Camadro JM.

Mol Cell Proteomics. 2016 Jul;15(7):2308-23. doi: 10.1074/mcp.M116.059378. Epub 2016 Apr 28. PMID: 27125826

Label-Free Quantitative Proteomics in Yeast. 

Léger TGarcia CVidelier M, Camadro JM.

Methods Mol Biol. 2016;1361:289-307. doi: 10.1007/978-1-4939-3079-1_16. PMID: 26483028

Publications pour lesquelles la plateforme et/ou ses ingénieurs sont remerciés

Souquet, B., Freed, E., Berto, A., Andric, V., Auduge, N., Reina-San-Martin, B., Lacy, E., and Doye, V. (2018) Nup133 Is Required for Proper Nuclear Pore Basket Assembly and Dynamics in Embryonic Stem Cells. Cell reports 23, 2443-2454

Madera-Salcedo, I. K., Danelli, L., Tiwari, N., Dema, B., Pacreau, E., Vibhushan, S., Birnbaum, J., Agabriel, C., Liabeuf, V., Klingebiel, C., Menasche, G., Macias-Silva, M., Benhamou, M., Charles, N., Gonzalez-Espinosa, C., Vitte, J., and Blank, U. (2018) Tomosyn functions as a PKCdelta-regulated fusion clamp in mast cell degranulation. Science signaling.

Futel, M., Le Bouffant, R., Buisson, I., Umbhauer, M., and Riou, J. F. (2018) Characterization of potential TRPP2 regulating proteins in early Xenopus embryos. Journal of cellular biochemistry 119, 10338-10350.

Jamin, A., Berthelot, L., Couderc, A., Chemouny, J. M., Boedec, E., Dehoux, L., Abbad, L., Dossier, C., Daugas, E., Monteiro, R. C., and Deschenes, G. (2018) Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice. J Autoimmun 89, 149-161.

Perez-Perez, M. E., Mauries, A., Maes, A., Tourasse, N. J., Hamon, M., Lemaire, S. D., and Marchand, C. H. (2017) The Deep Thioredoxome in Chlamydomonas reinhardtii: New Insights into Redox Regulation. Molecular plant 10, 1107-1125.

Mersni-Achour, R., Ben Cheikh, Y., Pichereau, V., Doghri, I., Etien, C., Dégremont, L., Saulnier, D., Fruitier-Arnaudin, I., Travers, MA. (2017) Factors other than metalloprotease are required for full virulence of French Vibrio tubiashii isolates in oyster larvae. Microbiology.

Forget, A., Bihannic, L., Cigna, S.M., Lefevre, C., Remke, M., Barnat, M., Dodier, S., Shirvani, H., Mercier, A., Mensah, A., et al. (2014). Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors. Developmental cell 29, 649-661.

Mersni-Achour, R., Imbert-Auvray, N., Huet, V., Cheikh, Y.B., Faury, N., Doghri, I., Rouatbi, S., Bordenave, S., Travers, M.A., Saulnier, D., et al. (2014). First description of French V. tubiashii strains pathogenic to mollusk: II. Characterization of properties of the proteolytic fraction of extracellular products. Journal of invertebrate pathology.

Morisse, S., Zaffagnini, M., Gao, X.H., Lemaire, S.D., and Marchand, C.H. (2014). Insight into Protein S-nitrosylation in Chlamydomonas reinhardtii.
Antioxidants & redox signaling.

Le H.-T., Gautier V., Kthiri F., Malki A., Messaoudi N., Mihoub M., Landoulsi A., An Y.J., Cha S.-S., and Richarme G. (2012). YajL, prokaryotic homolog of parkinsonism-associated protein DJ-1, functions as a covalent chaperone for thiol proteome.
J. Biol. Chem. 287, 5861–5870.

Dejouvencel T., Féron D., Rossignol P., Sapoval M., Kauffmann C., Piot J.-M., Michel J.-B., Fruitier-Arnaudin I., and Meilhac O. (2010). Hemorphin 7 reflects hemoglobin proteolysis in abdominal aortic aneurysm.
Arterioscler. Thromb. Vasc. Biol. 30, 269–275.
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Kthiri F., Gautier V., Le H.-T., Prère M.-F., Fayet O., Malki A., Landoulsi A., and Richarme G. (2010). Translational defects in a mutant deficient in YajL, the bacterial homolog of the parkinsonism-associated protein DJ-1.
J. Bacteriol. 192, 6302–6306.
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