Institut Jacques Monod Seminar – Maud Borensztein

Invited by the Greenberg Lab , Maud Borensztein (Team Epigenetic Reprogramming and Mammalian Development, IGMM, CNRS, University of Montpellier) will present an Institut Jacques Monod Seminar on the theme:

Reprogramming the X chromosome: insights from mammalian development and germline

Abstract:

Maud Borensztein team focuses on epigenetic mechanisms in mammalian development and reproduction, with a particular emphasis on X-chromosome dosage compensation. Since establishing her group at the Institut de Génétique Moléculaire de Montpellier (IGMM) in 2021, they have developed innovative tools to study gametogenesis and X-chromosome dynamics, both in vivo (using mouse models) and in vitro (using Primordial Germ Cell-like cells). Investigating the reactivation of the inactive X chromosome during germline specification in females—a unique epigenetic reprogramming process that highlights fine gene-regulation control—, they aim to uncover its timing, mechanisms, and biological implications.