L'équipe Palancade et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans PLOS genetics : Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Résumé : Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome…

L'équipe Courtier a publié un nouvel article dans Development : Evolution of a novel left-right asymmetry in organ size by co-option of a tissue rotation process Résumé : Left-right asymmetries have repeatedly evolved in diverse animals and affect the position, shape or size of specific organs. How novel left-right asymmetries arise remains unknown. Here, we examined Drosophila pachea,…

L'équipe Raote a contribué à la publication d'un nouvel article dans Nature communications : TUG protein acts through a disordered region to organize the early secretory pathway Résumé : The Endoplasmic Reticulum (ER)-Golgi Intermediate Compartment (ERGIC) is a network of tubules and vesicles known for producing COPI vesicles and receiving COPII vesicles from the ER. Much about…

L'équipe Palancade et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans PLOS Genetics : Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Abstract : Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome…

L'équipe Guichet a contribué à une nouvelle publication dans Journal of Evolutionary Biology : Sheltered load in fungal mating-type chromosomes revealed by fitness experiments Résumé : Sex chromosomes and mating-type chromosomes can carry large regions with suppressed recombination. As a result of a lower efficacy of selection, recessive deleterious mutations are expected to accumulate in these non-recombining…

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Epigenetics : PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation   Résumé : Genomic imprinting is the parent-of-origin specific monoallelic expression of genes that result from complex epigenetic interactions. It is often achieved by monoallelic 5-methylcytosine, resulting in the formation of differentially methylated regions…

L'équipe Ladoux-Mège, le laboratoire MSC et l'Institut Cochin ont publié en collaboration un nouvel article dans Biophysical Journal : The enteric nervous system is 10 times stiffer than the brain L’intestin est le seul organe de notre corps doté d’une innervation quasi-autonome, le système nerveux entérique, appelé communément le « second cerveau ». Le cerveau et à la…

L'équipe Romet-Lemonne/Jégou a publié une nouvelle publication dans PNAS : Continuous self-repair protects vimentin intermediate filaments from fragmentation Résumé : Intermediate filaments are key regulators of cell mechanics. Vimentin, a type of intermediate filament expressed in mesenchymal cells and involved in migration, forms a dense network in the cytoplasm that is constantly remodeling through filament transport, elongation/shortening,…

L'équipe Ladoux/Mège a contribué à la publication d'un nouvel article dans The European Physical Journal E : Osmotic pressure induces unexpected relaxation of contractile 3D microtissue   Résumé : Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…

L'équipe Minc a publié un nouvel article dans Current Biology : Cell division: Size-scaling cytoplasmic flows transport chromosomes to the right spot   Résumé : Early embryos undergo rounds of division, producing cells of reducing sizes that must scale the distance chromosomes segregate. A new study shows that this scaling results from a cell-size-dependent dampening of cytoplasmic flows…