L'équipe Doye a contribué à la publication d'un nouvel article dans Nature cell biology : Nuclear pores safeguard the integrity of the nuclear envelope   Résumé : Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange, which is essential for eukaryotes. Mutations in the central scaffolding components of NPCs are associated with genetic diseases, but how they manifest only in specific…

L'équipe Ribes/Nedelec a contribué à la publication d'un nouvel article dans Nature Communications : A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification   Résumé : Studying ciliary genes in the context of the human central nervous system is crucial for understanding the underlying causes of neurodevelopmental ciliopathies. Here, we use…

L'équipe Palancade a contribué à la publication d'un nouvel article dans Nature communications : A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors Résumé : Small nucleolar RNAs are non-coding transcripts that guide chemical modifications of RNA substrates and modulate gene expression at the epigenetic and post-transcriptional levels. However, the extent…

L'équipe Romet-Lemonne / Jégou a contribué à la publication d'un nouvel article dans Cell : Genetically encoded reporters of actin filament organization in living cells and tissues   Résumé : The cytoskeletal protein actin is crucial for cell shape and integrity throughout eukaryotes. Actin filaments perform essential biological functions, including muscle contraction, cell division, and tissue morphogenesis. These…

L'équipe Ladoux/Mège a publié un nouvel article dans Nature material : Force transmission is a master regulator of mechanical cell competition Résumé : Cell competition is a tissue surveillance mechanism for eliminating unwanted cells, being indispensable in development, infection and tumourigenesis. Although studies have established the role of biochemical mechanisms in this process, due to challenges in…

L'équipe Veitia a publié une nouvelle revue dans Trends in biochemical sciences : Rethinking transcription factor dynamics and transcription regulation in eukaryotes Résumé : Transcription factors (TFs) control gene expression by binding to specific DNA motifs in cis-regulatory elements. Cooperativity has been thought to ensure TF binding specificity. Recent research suggests that, at least in yeast, the role…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature communications : Histidine 73 methylation coordinates β-actin plasticity in response to key environmental factors Résumé : The functional importance of the methylation of histidine 73 (H73) in actin remains unclear. Focusing on cytoplasmic β-actin, present in all mammalian cells, we use molecular dynamics simulations with a polarizable…

L'équipe Palancade a publié un nouvel article dans Nature Communications : DNA lesions can frequently precede DNA:RNA hybrid accumulation   Résumé : While DNA:RNA hybrids contribute to multiple genomic transactions, their unscheduled formation is a recognized source of DNA lesions. Here, through a suite of systematic screens, we rather observed that a wide range of yeast mutant situations primarily…

L'équipe Conduit a publié un nouvel article dans Current Biology : Asymmetric microtubule nucleation from Golgi stacks promotes opposite microtubule polarity in axons and dendrites   Résumé : The neuronal microtubule cytoskeleton is highly polarized, with most microtubules growing away from the soma in axons (plus-end-out), but many microtubules growing toward the soma in dendrites (minus-end- out). This…

L'équipe Palancade a publié un nouvel article dans Nucleic Acid Research : RNA exosome-driven RNA processing instructs the duration of the unfolded protein response Résumé : Upon stresses, cellular compartments initiate adaptive programs meant to restore homeostasis. Dedicated to the resolution of transient perturbations, these pathways are typically maintained at a basal level, activated upon stress, and…