L'équipe Camadro a publié un nouvel article dans NAR Genomics & Bioinformatics : 3D models of fungal chromosomes to enhance visual integration of omics data   Résumé : The functions of eukaryotic chromosomes and their spatial architecture in the nucleus are reciprocally dependent. Hi-C experiments are routinely used to study chromosome 3D organization by probing chromatin interactions. Standard…

L'équipe Borghi a récemment contribué à la publication d'un article dans Experimental Hematology & Oncology : ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells   Résumé : Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in…

L'équipe Collignon a récemment publié un nouvel article dans Non-coding RNA : LADON , a Natural Antisense Transcript of NODAL , Promotes Tumour Progression and Metastasis in Melanoma   Résumé : The TGFβ family member NODAL, repeatedly required during embryonic development, has also been associated with tumour progression. Our aim was to clarify the controversy surrounding its involvement in…

L'équipe Minc a récemment publié un nouvel article dans Cell Dynamics : Cytoplasm mechanics and cellular organization   Résumé : As cells organize spatially or divide, they translocate many micron-scale organelles in their cytoplasm. These include endomembrane vesicles, nuclei, microtubule asters, mitotic spindles, or chromosomes. Organelle motion is powered by cytoskeleton forces but is opposed by viscoelastic forces imparted by…

L'équipe Cadoret a contribué a la publication d'un article dans EMBO reports : The nucleolar protein GNL3 prevents resection of stalled replication forks   Résumé : Faithful DNA replication requires specific proteins that protect replication forks and so prevent the formation of DNA lesions that may damage the genome. Identification of new proteins involved in this process is…

L'équipe Konstantinides a publié un nouvel article dans The FEBS Journal : Evolution of patterning   Résumé : Developing tissues are patterned in space and time; this enables them to differentiate their cell types and form complex structures to support different body plans. Although space and time are two independent entities, there are many examples of spatial patterns…

Le domaine forkhead de liaison à l’ADN reconnait également une séquence d’ARN riche en GG.   Cette étude, publiée dans Nucleic Acids Research, résulte d’une collaboration entre les équipes de Reiner A. Veitia (directeur de l’Institut de Biologie Francois Jacob et Professeur à l’Université Paris Cité) et l’équipe de Frédéric Ducongé (CEA-MIRCen, UMR CNRS 9199, Université…

L'équipe Ladoux / Mège a récemment contribué à la publication d'un nouvel article dans Nature Cell biology : A mechanosensitive caveolae–invadosome interplay drives matrix remodelling for cancer cell invasion Résumé : Invadosomes and caveolae are mechanosensitive structures that are implicated in metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix degradative invadosomes at…

L'équipe Camadro a récemment contribué à la publication d'un nouvel article dans Briefing in Bioinformatics : The five pillars of computational reproducibility: bioinformatics and beyond   Résumé : Computational reproducibility is a simple premise in theory, but is difficult to achieve in practice. Building upon past efforts and proposals to maximize reproducibility and rigor in bioinformatics, we present a…

L'équipe Courtier a récemment publié un nouvel article dans Current Opinion in Insect Science : The loci of insect phenotypic evolution   Résumé : Insects are important elements of terrestrial ecosystems because they pollinate plants, destroy crops, transmit diseases to livestock and humans, and are important components of food chains. Here, I used Gephebase, a manually curated database…