L'équipe Ribes/Nedelec a contribué à la publication d'un nouvel article dans Science Advances : GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration   Résumé : The saltatory migration of neurons is essential for brain formation. Whether mechanical stimuli regulate this process is unknown. Here, we show that the primary cilium acts as a mechanical sensor through…

L'équipe Wassmann a contribué à l'ouvrage Mammalian Oocyte Development : “JessTM Simple WesternTM”: A New Technology to Assess Protein Abundance in Mouse Oocytes Résumé : Traditional Western blot technology coupled with two-dimensional  SDS-PAGE has been used for decades to detect specific proteins in extracts. Here we describe an automated Western technology based on protein separation by capillary assay.…

L'équipe Jackson/Verbavatz a contribué à la publication d'un nouvel article dans Traffic : Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases Résumé : Arf and Rab family small GTPases and their regulators, GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), play a central role in membrane trafficking. In this study, we…

L'équipe Gazave a contribué à la publication d'un nouvel article dans BMC Genomics : A genome resource for the marine annelid Platynereis spp Résumé : The marine annelid Platynereis dumerilii is a model organism used in many research areas including evolution and development, neurobiology, ecology and regeneration. Here we present the genomes of P. dumerilii (laboratory culture…

L'équipe Veitia a publié un nouvel article dans Journal of inherited metabolic disease : Gene Dosage Sensitivity and Human Genetic Diseases Résumé : Here we review the historical background and contemporary insights into genetic dominance, focusing on haploinsufficiency (HI), that is, when the function of only one allele of a gene is not enough to ensure a…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans médecine/science : La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires Lemichez E, Morel C, Leduc C, Bassereau P. La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires [Caveolin-1 stiffens the plasma membrane and limits transcellular tunnel expansion]. Med…

L'équipe Ladoux/Mege a contribué à la publication d'un nouvel article dans Nature Communications : A multicellular star-shaped actin network underpins epithelial organization and connectivity Résumé : Epithelial tissues withstand external stresses while maintaining structural stability. Bicellular junctions and the actomyosin network support epithelial integrity, packing and remodelling. While their role in development and disease are well studied,…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Journal of biological chemistry: Structural and functional characterization of CREB-binding protein (CREBBP) as a histone propionyltransferase Résumé : In addition to histone acetylation, histone lysine propionylation (such as the H3K18Pr mark) has recently attracted significant attention as a common and abundant modification linking the cellular…

L'équipe Palancade et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans PLOS genetics : Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Résumé : Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome…

L'équipe Courtier a publié un nouvel article dans Development : Evolution of a novel left-right asymmetry in organ size by co-option of a tissue rotation process Résumé : Left-right asymmetries have repeatedly evolved in diverse animals and affect the position, shape or size of specific organs. How novel left-right asymmetries arise remains unknown. Here, we examined Drosophila pachea,…