The ImagoSeine platform contributed to the publication of a new article in Circulation: CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT   Abstract: BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions…

The Dumont Lab contributed to the publication of a new article in Molecular Biology of Cell: Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane   Abstract: Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of an…

The Ribes Lab contributed to the publication of a review in Biomedicines: Non-Mammalian Models for Understanding Neurological Defects in RASopathies   Abstract: RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders. Afflicting approximately one in a thousand newborns, RASopathies manifest…

The  Jackson/Verbavatz Lab contributed to the publication of a themed issue article: Staying on track – Keeping things running in a high-end scientific imaging core facility   Abstract: Modern life science research is a collaborative effort. Few research groups can single-handedly support the necessary equipment, expertise and personnel needed for the ever-expanding portfolio of technologies that are required…

The Raote Lab published a new article in Nature communications: TANGO1 inhibitors reduce collagen secretion and limit tissue scarring   Abstract: Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies are lacking. A promising approach would be…

The Duharcourt Lab published a new review in WIREs RNA : Small-RNA-guided histone modifications and somatic genome elimination in ciliates   Abstract: Transposable elements and other repeats are repressed by small-RNA-guided histone modifications in fungi, plants and animals. The specificity of silencing is achieved through base-pairing of small RNAs corresponding to the these genomic loci to nascent noncoding…

The Conduit Lab published a new article in Journal of Cell Science: γ-TuRCs and Augmin are required for the development of highly branched dendritic arbors in Drosophila   Abstract: Microtubules are nucleated by γ-tubulin ring complexes (γ-TuRCs) and are essential for neuronal development. Nevertheless, γ-TuRC depletion has been reported to perturb only higher-order branching in elaborated Drosophila larval class IV…

The Palancade team contributed to the editorial published in the special edition of Yeast: Gene transcription in yeasts: From molecules to integrated processes   The cover image was created by Benoît Palancade and Coralie Goncalves.  

The Palancade Lab contributed to the publication of a new article in Nature communications : Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation Abstract: Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences…