The Palancade Lab contributed to the publication of a new article in Nature communications : Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation Abstract: Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences…

The Greenberg Lab published a new article in Nature structural & molecular biology: The impact of DNA methylation on CTCF-mediated 3D genome organization Abstract: Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although the role of DNA methylation at gene promoters and repetitive elements has been extensively studied, the function of DNA methylation…

The ProtéoSeine et ImagoSeine plateforms contributed to the publication of an article in Nature communications: Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy Abstract Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp. have evolved sophisticated strategies…

The Gazave Lab published a new article in Scientific report: Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate Ciona Abstract: Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis is…

The Jackson/Verbavatz Lab published a new article eLife: The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions   Abstract: Cell motility processes highly depend on the membrane distribution of Phosphoinositides, giving rise to cytoskeleton reshaping and membrane trafficking events. Membrane contact sites serve as platforms for direct lipid exchange…

The Courtier Lab contributed to a new article published in BMC Bioinformatics : CNCA aligns small annotated genomes   Abstract: Background To explore the evolutionary history of sequences, a sequence alignment is a first and necessary step, and its quality is crucial. In the context of the study of the proximal origins of SARS-CoV-2 coronavirus, we wanted to…

The Pintard lab recently published a new article in Journal of Cell Biology: Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans   Abstract: Microtubule-severing enzymes (MSEs), such as Katanin, Spastin, and Fidgetin play essential roles in cell division and neurogenesis. They damage the microtubule (MT) lattice, which can either destroy or amplify the…

The Courtier lab recently published a new article in BMC Ecology and Evolution: Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences Abstract: Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood. Here we examine…