L'équipe Greenberg a publié un nouvel article dans Nucleic Acids Research : The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation   Résumé : During mammalian embryogenesis, both the 5-cytosine DNA methylation (5meC) landscape and three dimensional (3D) chromatin architecture are profoundly remodeled during a process known as ‘epigenetic reprogramming.’ An understudied aspect of epigenetic…

L'équipe Grange/Geigl a contribué à la publication d'un nouvel article dans Annals of Rheumatic Diseases : SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase   Résumé : Objectives Inflammatory mediators such as interleukin 6 (IL-6) are known to activate catabolic responses in chondrocytes during osteoarthritis (OA). This study aimed to investigate the role of a downstream…

L'équipe Romet-Lemonne / Jégou a publié un nouvel Editorial dans European Journal of Cell Biology : Editorial - In vitro reconstitution of cytoskeletal processes   Jégou A, Romet-Lemonne G. Editorial - In vitro reconstitution of cytoskeletal processes. Eur J Cell Biol. 2024 Sep;103(3):151443. doi: 10.1016/j.ejcb.2024.151443. Epub 2024 Jul 14. PMID: 39048475.

L'équipe Minc a publié un nouvel article dans Molecular Biology of the Cell : Mechanical strategies supporting growth and size diversity in Filamentous Fungi   Résumé : The stereotypical tip growth of filamentous fungi supports their lifestyles and functions. It relies on the polarized remodeling and expansion of a protective elastic cell wall (CW) driven by large cytoplasmic…

L'équipe Dumont a publié un nouvel article dans Nature Communication : Maternal inheritance of functional centrioles in two parthenogenetic nematodes   Résumé : Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in animal cells. In sexually reproducing species, centrioles degenerate during oogenesis and female meiosis is usually acentrosomal.…

L'équipe Raote a contribué à la publication d'un nouvel article dans Developmental Cell : Endoplasmic reticulum exit sites are segregated for secretion based on cargo size   Résumé : TANGO1, TANGO1-Short, and cTAGE5 form stable complexes at the endoplasmic reticulum exit sites (ERES) to preferably export bulky cargoes. Their C-terminal proline-rich domain (PRD) binds Sec23A and affects COPII assembly. The PRD in…