L'équipe Dumont a publié un nouvel article dans Current Biology : Regulation of outer kinetochore assembly during meiosis I and II by CENP-A and KNL-2/M18BP1 in C. elegans oocytes   Résumé : During cell division, chromosomes build kinetochores that attach to spindle microtubules. Kinetochores usually form at the centromeres, which contain CENP-A nucleosomes. The outer kinetochore, which is the core…

L'équipe Pintard a contribué à la publication d'un nouvel article dans Nucleic Acids Research : Enhanced Golden Gate Assembly: evaluating overhang strength for improved ligation efficiency   Résumé : Molecular cloning, a routine yet essential technique, relies heavily on efficient ligation, which can be significantly improved using Golden Gate Assembly (GGA). A key component of GGA is the use…

L'équipe Gazave a publié un nouvel article dans Genome Biology and Evolution : Evolution of apoptotic signalling pathways within lophotrochozoans   Résumé : Apoptosis is the main form of regulated cell death in metazoans. Apoptotic pathways are well characterised in nematode, fly and mammals, leading to a vision of the conservation of apoptotic pathways in metazoans. However, we…

L'équipe Minc a contribué à la publication d'un nouvel article dans Médecine / Sciences : Un rôle des microtubules astraux dans l’orientation de la division cellulaire   Smolen P, Ruiz L, Barai A, Minc N, Delacour D. Un rôle des microtubules astraux dans l’orientation de la division cellulaire - Quand la longueur compte… aussi ! [A role…

L'équipe Greenberg a publié un nouvel article dans Nucleic Acids Research : The impact of the embryonic DNA methylation program on CTCF-mediated genome regulation   Résumé : During mammalian embryogenesis, both the 5-cytosine DNA methylation (5meC) landscape and three dimensional (3D) chromatin architecture are profoundly remodeled during a process known as ‘epigenetic reprogramming.’ An understudied aspect of epigenetic…

L'équipe Grange/Geigl a contribué à la publication d'un nouvel article dans Annals of Rheumatic Diseases : SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase   Résumé : Objectives Inflammatory mediators such as interleukin 6 (IL-6) are known to activate catabolic responses in chondrocytes during osteoarthritis (OA). This study aimed to investigate the role of a downstream…

L'équipe Romet-Lemonne / Jégou a publié un nouvel Editorial dans European Journal of Cell Biology : Editorial - In vitro reconstitution of cytoskeletal processes   Jégou A, Romet-Lemonne G. Editorial - In vitro reconstitution of cytoskeletal processes. Eur J Cell Biol. 2024 Sep;103(3):151443. doi: 10.1016/j.ejcb.2024.151443. Epub 2024 Jul 14. PMID: 39048475.

L'équipe Minc a publié un nouvel article dans Molecular Biology of the Cell : Mechanical strategies supporting growth and size diversity in Filamentous Fungi   Résumé : The stereotypical tip growth of filamentous fungi supports their lifestyles and functions. It relies on the polarized remodeling and expansion of a protective elastic cell wall (CW) driven by large cytoplasmic…

L'équipe Dumont a publié un nouvel article dans Nature Communication : Maternal inheritance of functional centrioles in two parthenogenetic nematodes   Résumé : Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in animal cells. In sexually reproducing species, centrioles degenerate during oogenesis and female meiosis is usually acentrosomal.…

L'équipe Raote a contribué à la publication d'un nouvel article dans Developmental Cell : Endoplasmic reticulum exit sites are segregated for secretion based on cargo size   Résumé : TANGO1, TANGO1-Short, and cTAGE5 form stable complexes at the endoplasmic reticulum exit sites (ERES) to preferably export bulky cargoes. Their C-terminal proline-rich domain (PRD) binds Sec23A and affects COPII assembly. The PRD in…