L'équipe Conduit a publié un nouvel article dans Journal of Cell Biology : A structural model for the autoinhibition of the γ-TuRC–activating CM1 domain Résumé : Microtubule nucleation by γ-tubulin ring complexes (γ-TuRCs) must be spatiotemporally controlled to avoid major cell division errors. γ-TuRCs are activated by the centrosome-specific binding of a highly conserved centrosomin motif 1…

L'équipe Ladoux/Mège a publié un nouvel article dans Nature Communications : A principal-stress rule for cell division in epithelia Résumé : Dense active materials must continuously relieve internal mechanical stress to remain structurally stable as they are driven far from equilibrium. In epithelial tissues, this relief occurs through cell division, where, according to Hertwig’s century-old rule, cells…

L'équipe Bonazzi a publié un nouvel article dans Nature Communications : Bacterial growth under confinement requires transcriptional adaptation to resist turgor pressure build-up Résumé : Bacterial proliferation in confined spaces occurs in biofilms, intracellular compartments, or infection sites, generating mechanical constraints. We investigated how growth-induced mechanical pressure affects bacterial physiology using a microfluidic device ensuring nutrient access.…

L'équipe Ladoux/Mège a publié un nouvel article dans Nature Communications : Extracellular-matrix mediated stresses spatially bias myoblast fusion and myotube growth Résumé : Myoblast fusion into multinucleated myotubes is essential for skeletal muscle development and repair, yet how tissue-scale mechanics contributes to this process remains poorly understood. Here, we show that primary myoblasts behave as an evolving…

L'équipe Duharcourt a publié une review dans Nature Reviews Genetics : The mechanistic and evolutionary diversity of programmed DNA elimination Résumé : Beyond somatic mutations, the genetic makeup of an organism is often assumed to remain constant across all cells or nuclei within individuals. However, some organisms exhibit programmed DNA elimination (PDE), whereby specific cell lineages lose…

L'équipe Veitia a publié un nouvel article dans FASEB Journal : Nonlinearities and Switch-Like Behavior in Gene Expression: From Genetics to Biochemistry and Back. Résumé : Many developmental and physiological outcomes depend on transcriptional thresholds or switches. The transcriptional output, ultimately measured as mature RNA, is determined by a series of molecular steps that can introduce thresholds,…

L'équipe Prioleau a publié un nouvel article dans The FEBS Journal : Ploidy-dependent modulation of DNA replication kinetics in Xenopus Résumé : An important question in cell biology is how DNA replication programs scale with genome size following polyploidization, an evolutionary process that increases DNA content without proportionally extending the cell cycle duration. In particular, comparative…

L'équipe Ladoux/Mège a publié un nouvel article dans Molecular Biology of the Cell : Vimentin bridges scales to convert polarized cell locomotion into coordinated collective migration Résumé : Collective cell migration is central in development and disease. Vimentin is an intermediate filament protein expressed by epithelial cells at the edge of wounds where collective cell migration is…

L'équipe Guichet a publié un nouvel article dans mBio : Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina Résumé : Nuclear movement, positioning, and the mechanical constraints applied to the nucleus play important roles in cellular identity, physiology, and gene regulation. This process, known…