La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Scientific reports : The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina Résumé : BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and…

L'équipe Konstantinides a contribué à la publication d'un nouvel article dans Cell Reports : Embryonic dopaminergic neuron activity sustains lifelong locomotion in Drosophila Résumé : Locomotor skills arise early in life and are maintained throughout an animal’s lifespan, yet how this continuity is achieved despite major neural remodeling remains unclear. Using Drosophila, which undergoes complete metamorphosis, we show…

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans Cell Reports : Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts Résumé : Similarities and differences in the self-assembly of actin filaments from different species inform our understanding of its evolution. However, this basic knowledge is largely incomplete. Here, we systematically characterize assembly kinetics for…

L'équipe Veitia a publié une nouvelle review dans Biogerontology : Genome integrity, somatic mutation, and the N-of-1 imperative in aging research Aging research has made remarkable progress in describing aging through the genetic architecture of longevity, epigenetic clocks, proteomic signatures, and systems-level analyses. Yet a critical dimension remains underrepresented: the role of genome integrity, germline and…

L'équipe Borghi a publié un nouvel article dans Physical Review E : Nuclear pore complex distribution on the nuclear envelope: Insights into curvature, chromatin, and actin contributions Résumé : The Nuclear Pore Complex (NPC) is an ancestral feature of eukaryotic cells, essential for the exchange of material and information between cytoplasm and nucleoplasm. While typical eukaryotic cells…

L'équipe Ladoux/Mege a publié une nouvelle review dans Trends in Cell Biology : Biophysical principles of cell competition and elimination Highlights Cells within heterogeneous tissues can use forces to outcompete and eliminate cells of lower mechanical fitness through various strategies. Cellular biophysical properties, such as cell–cell or cell–substrate adhesion, force generation and transmission, contractility, and stiffness, can provide…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Nature Communications : Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events Résumé : Meiotic progression relies on maintaining a precise balance between cyclin B/CDK1 activity and the phosphatase PP2A-B55. The latter is…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Cell Death & Disease : EMILIN1 emerges as a TGFβ/SETDB1-regulated secreted biomarker in Duchenne muscular dystrophy Résumé : Duchenne muscular dystrophy (DMD) is an incurable muscle-wasting disorder characterized by chronic membrane damage, inflammation, and progressive fibrosis. Fibrosis in DMD is driven by sustained TGFβ…

L'équipe Jackson/Verbavatz a contribué à un nouvel article publié dans Journal of Microscopy : Stress and conflict management in core facilities - News from an imaging survey Résumé : While conflict management is a well-known challenge for people working in the service sector, this topic remains largely unexplored in scientific imaging core facilities, despite frequent interactions with…

L'équipe Duharcourt a publié un nouvel article dans Nucleic Acids Research : A developmental condensin I complex assists the Paramecium PiggyMac domesticated transposase during programmed DNA elimination Résumé : Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium, elimination of transposable elements and their relics requires the…