L'équipe Guichet a publié un nouvel article dans mBio : Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina Résumé : Nuclear movement, positioning, and the mechanical constraints applied to the nucleus play important roles in cellular identity, physiology, and gene regulation. This process, known…

L'équipe Veitia a publié un nouvel article dans FASEB Journal : Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs Résumé : FOXL2 is a forkhead transcription factor (TF) essential for granulosa-cell identity and function, yet how post-translational modifications tune its activity remains incompletely…

L'équipe Guichet a contribué à la publication d'un nouvel article dans Biochimica et Biophysica Acta (BBA) - Molecular Cell Research : Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina Abstract Microtubule-based organelle…

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans PNAS : Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end Résumé : Significance The cytoskeleton is composed of three types of filaments: actin, microtubules, and intermediate filaments, which coordinate to control cell shape, mechanics, and movement. Among them, the contribution of vimentin intermediate filaments to…

La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Biomacromolecules : Nanoscale Structural Insights into Human Pulmonary Mucus and Its Snail Slime-Based Surrogate Using Automated TEM Image Processing Résumé : Pulmonary drug delivery is a promising approach for treating respiratory diseases, but the mucus barrier in bronchial airways often hinders therapeutic efficacy.…

L'équipe Romet-Lemonne/Jégou Lab a publié un nouvel article dans Journal of Cell Biology : Inorganic phosphate rapidly switches the stability of Arp2/3-induced actin branches   Résumé : Actin filaments often appear as branches, nucleated by the Arp2/3 complex. Arp2 and Arp3 are ATPases, which adopt different nucleotide-dependent conformations. We investigated how the nucleotide state of mammalian Arp2/3 complexes…

L'équipe Conduit a publié une nouvelle review dans Journal of Neurochemistry : The Golgi as a Microtubule Organiser in Neurons Résumé : Microtubules are fundamental to neuronal architecture, providing the structural framework and transport tracks essential for polarisation, compartmentalisation and growth. While the centrosome is the canonical microtubule-organising centre (MTOC), neurons also rely on non-centrosomal MTOCs (ncMTOCs)…

L'équipe Minc a publié un nouvel article dans Current Biology : A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos Résumé : Nuclei and mitotic spindles are actively positioned at defined locations within cells to regulate cell polarity, division, and multicellular morphogenesis.1 ,2 ,3 ,4  Forces generated by cytoskeleton networks…

L'équipe Borghi a contribué à un nouvel article publié dans The EMBO Journal : Chromosome condensation mechanically primes the nucleus for mitosis Résumé : Accurate transition into mitosis driven by cyclin B1-CDK1 activity is essential to avoid chromosome segregation errors and preserve genome integrity. How this activity is spatially controlled to trigger mitotic onset remains unclear.…

L'équipe Jackson/Verbavatz a contribué à la publication d'un nouvel article dans Cell Reports: Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites Résumé : The spatial organization and dynamics of the endoplasmic reticulum (ER) govern when and where ER tubules engage with other organelles and the plasma membrane. We previously found that ER tubules are closely associated with…