La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Biomacromolecules : Nanoscale Structural Insights into Human Pulmonary Mucus and Its Snail Slime-Based Surrogate Using Automated TEM Image Processing Résumé : Pulmonary drug delivery is a promising approach for treating respiratory diseases, but the mucus barrier in bronchial airways often hinders therapeutic efficacy.…

L'équipe Romet-Lemonne/Jégou Lab a publié un nouvel article dans Journal of Cell Biology : Inorganic phosphate rapidly switches the stability of Arp2/3-induced actin branches   Résumé : Actin filaments often appear as branches, nucleated by the Arp2/3 complex. Arp2 and Arp3 are ATPases, which adopt different nucleotide-dependent conformations. We investigated how the nucleotide state of mammalian Arp2/3 complexes…

L'équipe Conduit a publié une nouvelle review dans Journal of Neurochemistry : The Golgi as a Microtubule Organiser in Neurons Résumé : Microtubules are fundamental to neuronal architecture, providing the structural framework and transport tracks essential for polarisation, compartmentalisation and growth. While the centrosome is the canonical microtubule-organising centre (MTOC), neurons also rely on non-centrosomal MTOCs (ncMTOCs)…

L'équipe Minc a publié un nouvel article dans Current Biology : A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos Résumé : Nuclei and mitotic spindles are actively positioned at defined locations within cells to regulate cell polarity, division, and multicellular morphogenesis.1 ,2 ,3 ,4  Forces generated by cytoskeleton networks…

L'équipe Borghi a contribué à un nouvel article publié dans The EMBO Journal : Chromosome condensation mechanically primes the nucleus for mitosis Résumé : Accurate transition into mitosis driven by cyclin B1-CDK1 activity is essential to avoid chromosome segregation errors and preserve genome integrity. How this activity is spatially controlled to trigger mitotic onset remains unclear.…

L'équipe Jackson/Verbavatz a contribué à la publication d'un nouvel article dans Cell Reports: Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites Résumé : The spatial organization and dynamics of the endoplasmic reticulum (ER) govern when and where ER tubules engage with other organelles and the plasma membrane. We previously found that ER tubules are closely associated with…

L'équipe Borghi a publié un nouvel article dans Soft Matter : Charles Murray van Wyk, a discreet pioneer of fibre network mechanics Abstract : In 1946, C. M. van Wyk published a seminal theoretical paper on wool mechanics, explaining why the mechanical stress applied to wool is a function of the inverse cube of its volume. In…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Scientific reports : The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina Résumé : BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and…

L'équipe Konstantinides a contribué à la publication d'un nouvel article dans Cell Reports : Embryonic dopaminergic neuron activity sustains lifelong locomotion in Drosophila Résumé : Locomotor skills arise early in life and are maintained throughout an animal’s lifespan, yet how this continuity is achieved despite major neural remodeling remains unclear. Using Drosophila, which undergoes complete metamorphosis, we show…

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans Cell Reports : Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts Résumé : Similarities and differences in the self-assembly of actin filaments from different species inform our understanding of its evolution. However, this basic knowledge is largely incomplete. Here, we systematically characterize assembly kinetics for…