La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Circulation : CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT   Résumé : BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug…

L'équipe Dumont a contribué à la publication d'un nouvel article dans Molecular Biology of Cell : Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane   Résumé : Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of…

L'équipe Ribes a contribué à la publication d'une revue dans Biomedicines : Non-Mammalian Models for Understanding Neurological Defects in RASopathies   Résumé : RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders. Afflicting approximately one in a thousand newborns, RASopathies manifest…

L'équipe Jackson/Verbavatz a contribué à la publication d'un article thématique : Staying on track – Keeping things running in a high-end scientific imaging core facility   Résumé : Modern life science research is a collaborative effort. Few research groups can single-handedly support the necessary equipment, expertise and personnel needed for the ever-expanding portfolio of technologies that are required…

L'équipe Raote a publié un nouvel article dans Nature communications : TANGO1 inhibitors reduce collagen secretion and limit tissue scarring   Résumé : Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies are lacking. A promising approach…

L'équipe Duharcourt a publié une nouvelle revue dans WIREs RNA : Small-RNA-guided histone modifications and somatic genome elimination in ciliates   Résumé : Transposable elements and other repeats are repressed by small-RNA-guided histone modifications in fungi, plants and animals. The specificity of silencing is achieved through base-pairing of small RNAs corresponding to the these genomic loci to nascent…

L'équipe Conduit a publié un nouvel article dans Journal of Cell Science : γ-TuRCs and Augmin are required for the development of highly branched dendritic arbors in Drosophila   Résumé : Microtubules are nucleated by γ-tubulin ring complexes (γ-TuRCs) and are essential for neuronal development. Nevertheless, γ-TuRC depletion has been reported to perturb only higher-order branching in elaborated Drosophila larval…

L'équipe Palancade a contribué à la publication à l'éditorial publié dans l'édition spéciale de Yeast : Gene transcription in yeasts: From molecules to integrated processes   L'image de couverture de l'édition a été réalisée par Benoît Palancade et Coralie Goncalves.  

L'équipe Palancade a contribué à la publication d'un nouvel article dans Nature communications : Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation Résumé : Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these…

L'équipe Greenberg a publié un nouvel article dans Nature structural & molecular biology : The impact of DNA methylation on CTCF-mediated 3D genome organization Résumé Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although the role of DNA methylation at gene promoters and repetitive elements has been extensively studied, the function of…