L'équipe Camadro et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans eBioMedicine : Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability   Résumé : Background The high variability in clinical and metabolic presentations of inborn errors of cobalamin (cbl) metabolism (IECM), such as the cblC/epicblC types…

L'équipe Raote a contribué à la publication d'un nouvel article dans PNAS : A model for collagen secretion by intercompartmental continuities   Résumé : Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too large for export by the standard COPII-coated vesicle of 60 nm…

L'équipe Balavoine a récemment publié un nouvel article dans Plos One : Fast cycling culture of the annelid model Platynereis dumerilii   Résumé : Platynereis dumerilii, a marine annelid, is a model animal that has gained popularity in various fields such as developmental biology, biological rhythms, nervous system organization and physiology, behaviour, reproductive biology, and epigenetic regulation. The…

L'équipe Ribes a publié un nouvel article dans Emerging topics in life sciences : Stem cell-derived models of spinal neurulation   Résumé : This review is the fruit of an enriching collaboration with my thesis supervisors Vanessa Ribes and Stéphane Nedelec (Institut du Fer à Moulin), along with Martin Catala (Institut de Biologie Paris Seine) and Mikaëlle Bocel…

L'équipe Courtier a récemment publié un nouvel article dans Plos one : Recommended distances for physical distancing during COVID-19 pandemics reveal cultural connections between countries   Résumé : During COVID-19 pandemic several public health measures were implemented by diverse countries to reduce the risk of COVID-19, including social distancing. Here we collected the minimal distance recommended by each…

L'équipe Léon a contribué à la publication d'un article dans Molecular Cell : Ubiquiton - An inducible, linkage-specific polyubiquitylation tool   Résumé : The posttranslational modifier ubiquitin regulates most cellular processes. Its ability to form polymeric chains of distinct linkages is key to its diverse functionality. Yet, we still lack the experimental tools to induce linkage-specific polyubiquitylation of…

L'équipe Camadro a publié un nouvel article dans NAR Genomics & Bioinformatics : 3D models of fungal chromosomes to enhance visual integration of omics data   Résumé : The functions of eukaryotic chromosomes and their spatial architecture in the nucleus are reciprocally dependent. Hi-C experiments are routinely used to study chromosome 3D organization by probing chromatin interactions. Standard…

L'équipe Borghi a récemment contribué à la publication d'un article dans Experimental Hematology & Oncology : ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells   Résumé : Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in…

L'équipe Collignon a récemment publié un nouvel article dans Non-coding RNA : LADON , a Natural Antisense Transcript of NODAL , Promotes Tumour Progression and Metastasis in Melanoma   Résumé : The TGFβ family member NODAL, repeatedly required during embryonic development, has also been associated with tumour progression. Our aim was to clarify the controversy surrounding its involvement in…

L'équipe Minc a récemment publié un nouvel article dans Cell Dynamics : Cytoplasm mechanics and cellular organization   Résumé : As cells organize spatially or divide, they translocate many micron-scale organelles in their cytoplasm. These include endomembrane vesicles, nuclei, microtubule asters, mitotic spindles, or chromosomes. Organelle motion is powered by cytoskeleton forces but is opposed by viscoelastic forces imparted by…