L'équipe Greenberg a contribué à la publication d'un nouvel article dans Epigenetics : PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation   Résumé : Genomic imprinting is the parent-of-origin specific monoallelic expression of genes that result from complex epigenetic interactions. It is often achieved by monoallelic 5-methylcytosine, resulting in the formation of differentially methylated regions…

L'équipe Ladoux-Mège a publié un nouvel article dans Biophysical Journal : The enteric nervous system is 10 times stiffer than the brain Résumé : Neural tissues of the central nervous system are among the softest and most fragile in the human body, protected from mechanical perturbation by the skull and the spine. In contrast, the enteric nervous…

L'équipe Romet-Lemonne/Jégou a publié une nouvelle publication dans PNAS : Continuous self-repair protects vimentin intermediate filaments from fragmentation Résumé : Intermediate filaments are key regulators of cell mechanics. Vimentin, a type of intermediate filament expressed in mesenchymal cells and involved in migration, forms a dense network in the cytoplasm that is constantly remodeling through filament transport, elongation/shortening,…

L'équipe Ladoux/Mège a contribué à la publication d'un nouvel article dans The European Physical Journal E : Osmotic pressure induces unexpected relaxation of contractile 3D microtissue   Résumé : Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…

L'équipe Minc a publié un nouvel article dans Current Biology : Cell division: Size-scaling cytoplasmic flows transport chromosomes to the right spot   Résumé : Early embryos undergo rounds of division, producing cells of reducing sizes that must scale the distance chromosomes segregate. A new study shows that this scaling results from a cell-size-dependent dampening of cytoplasmic flows…

L'équipe Minc a publié un nouvel article dans Journal of the royal society interface : Dynamic clamping induces rotation-to-beating transition of pinned filaments in gliding assays Résumé : We used numerical simulations to investigate how properties of motor proteins control the dynamical behaviour of driven flexible filaments. A filament on top of a patch of anchored motor proteins…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Rapid Communications in Mass Spectometry : Electron Transfer Dissociation and Synchrotron UV Photodissociation of Trapped Sodiated Ions Produced From Polyacrylates by Electrospray Ionization   Résumé : Rationale Poly (acrylates)s can be distinguished from one another by the nature of their side chains. From model poly (acrylates)s, the…

L'équipe Ladoux/Mege a publié un nouvel article dans PNAS : Flocking and giant fluctuations in epithelial active solids Significance During embryonic development and wound healing, epithelial cells usually display in-plane polarity over large spatial scales and move coherently. However, most in vitro studies have examined the fluid-like chaotic dynamics of epithelial cells, in which collective cellular flows…

L'équipe Wassmann a publié un nouvel article dans Current Biology : Prolonged metaphase II arrest weakens Aurora B/C-dependent error correction in mouse oocytes   Résumé : Segregation errors in meiosis lead to aneuploid gametes and consequently to the development of trisomies, spontaneous abortion and fertility issues. Chromosome attachment to the microtubules of the bipolar spindle is a…