L'équipe Minc a publié un nouvel article dans Current Biology : A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos Résumé : Nuclei and mitotic spindles are actively positioned at defined locations within cells to regulate cell polarity, division, and multicellular morphogenesis.1 ,2 ,3 ,4  Forces generated by cytoskeleton networks…

L'équipe Borghi a contribué à un nouvel article publié dans The EMBO Journal : Chromosome condensation mechanically primes the nucleus for mitosis Résumé : Accurate transition into mitosis driven by cyclin B1-CDK1 activity is essential to avoid chromosome segregation errors and preserve genome integrity. How this activity is spatially controlled to trigger mitotic onset remains unclear.…

L'équipe Jackson/Verbavatz a contribué à la publication d'un nouvel article dans Cell Reports: Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites Résumé : The spatial organization and dynamics of the endoplasmic reticulum (ER) govern when and where ER tubules engage with other organelles and the plasma membrane. We previously found that ER tubules are closely associated with…

L'équipe Borghi a publié un nouvel article dans Soft Matter : Charles Murray van Wyk, a discreet pioneer of fibre network mechanics Abstract : In 1946, C. M. van Wyk published a seminal theoretical paper on wool mechanics, explaining why the mechanical stress applied to wool is a function of the inverse cube of its volume. In…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Scientific reports : The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina Résumé : BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and…

L'équipe Konstantinides a contribué à la publication d'un nouvel article dans Cell Reports : Embryonic dopaminergic neuron activity sustains lifelong locomotion in Drosophila Résumé : Locomotor skills arise early in life and are maintained throughout an animal’s lifespan, yet how this continuity is achieved despite major neural remodeling remains unclear. Using Drosophila, which undergoes complete metamorphosis, we show…

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans Cell Reports : Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts Résumé : Similarities and differences in the self-assembly of actin filaments from different species inform our understanding of its evolution. However, this basic knowledge is largely incomplete. Here, we systematically characterize assembly kinetics for…

L'équipe Veitia a publié une nouvelle review dans Biogerontology : Genome integrity, somatic mutation, and the N-of-1 imperative in aging research Aging research has made remarkable progress in describing aging through the genetic architecture of longevity, epigenetic clocks, proteomic signatures, and systems-level analyses. Yet a critical dimension remains underrepresented: the role of genome integrity, germline and…

L'équipe Borghi a publié un nouvel article dans Physical Review E : Nuclear pore complex distribution on the nuclear envelope: Insights into curvature, chromatin, and actin contributions Résumé : The Nuclear Pore Complex (NPC) is an ancestral feature of eukaryotic cells, essential for the exchange of material and information between cytoplasm and nucleoplasm. While typical eukaryotic cells…

L'équipe Ladoux/Mege a publié une nouvelle review dans Trends in Cell Biology : Biophysical principles of cell competition and elimination Highlights Cells within heterogeneous tissues can use forces to outcompete and eliminate cells of lower mechanical fitness through various strategies. Cellular biophysical properties, such as cell–cell or cell–substrate adhesion, force generation and transmission, contractility, and stiffness, can provide…