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Collignon Lab – Neural crest cell recruitment and reprogramming as central drivers of embryonic limb regeneration

L'équipe Collignon a contribué à la publication d'un nouvel article dan PNAS : Neural crest cell recruitment and reprogramming as central drivers of embryonic limb regeneration Résumé : Significance Mouse embryos possess the remarkable ability to regenerate amputated forelimb buds at E10.5—a capacity lost just 2 d later. We identify neural crest cells (NCCs) as key drivers…

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Ladoux/Mege Lab – Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization

L'équipe Ladoux-Mège a contribué à la publication d'un nouvel article dans Science advances : Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization Résumé : Cells rely on cadherin-based adherens junctions (AJs) to form cohesive tissues. To establish contact, cells generate pushing forces through branched actin polymerization mediated by the actin-related protein…

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Ladoux/Mege Lab – Radical scaling: beyond our feet and fingers

L'équipe Ladoux/Mege a publié un nouvel article dans Soft Matter : Radical scaling: beyond our feet and fingers Résumé : Scaling laws arise and are eulogized across disciplines from natural to social sciences for providing pithy, quantitative, ‘scale-free’, and ‘universal’ power law relationships between two variables. On a log–log plot, the power laws display as straight lines,…

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Borghi Lab – Chlamydia trachomatis highjacks host MYO1C for actin cage recruitment at the bacterial inclusion

L'équipe Borghi a contribué la publication d'un nouvel article dans Microbiological Research : Chlamydia trachomatis highjacks host MYO1C for actin cage recruitment at the bacterial inclusion Résumé : Chlamydia trachomatis (Ct), a Gram-negative obligate intracellular pathogen, manipulates host actin dynamics to facilitate its entry, development, and exit. It assembles a dynamic actin cage around its intracellular niche,…

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Borghi Lab – Meningococci drive host membrane tubulation to recruit their signaling receptors

L'équipe Borghi a contribué à la publication d'un nouvel article dans Nature communications : Meningococci drive host membrane tubulation to recruit their signaling receptors Résumé : Once passed into the bloodstream, bacterial pathogens have a limited time to interact with permissive receptors at the surface of host cells. Neisseria meningitidis has developed an extremely effective strategy allowing it to find its…

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Pintard Lab – Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis

L'équipe Pintard a publié un nouvel article dans The Journal of Cell biology : Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis Résumé : Microtubule-severing enzymes are evolutionarily conserved AAA-ATPases that sever microtubules, thereby regulating diverse microtubule-dependent cellular processes. How these enzymes couple Microtubule binding with ATP hydrolysis to trigger microtubule-remodeling remains poorly understood.…

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Veitia Lab – Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model

L'équipe Veitia a publié un nouvel article dans Molecular & Cellular Proteomics : Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model.   Résumé : Background Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. This study…

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