L'équipe Borghi a publié un nouvel article dans PLoS Computational Biology : Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy   Résumé : Segmentation and detection of biological objects in fluorescence microscopy is of paramount importance in cell imaging. Deep learning approaches have recently shown promise to advance, automatize and accelerate analysis. However, most of…

L'équipe Léon a publié, en collaboration avec la plateforme ProtéoSeine, un nouvel article dans Plos Genetics : A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition   Résumé : The yeast Saccharomyces cerevisiae thrives in sugar-rich environments by rapidly consuming glucose and favoring alcoholic fermentation. This strategy is tightly regulated by the glucose…

La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Communication Biology : Myocardial disarray drives metabolic inefficiency in human cardiomyocytes   Résumé : Adult cardiomyocytes are embedded within a highly organized myocardial microenvironment that imposes critical geometric cues essential for the alignment and distribution of organelles and the shaping of their unique, rectangular cellular morphology.…

L'équipe Raote a contribué à la publication d'un nouvel article dans Nature reviews molecular cell biology : Towards a unified framework for the function of endoplasmic reticulum exit sites Résumé : Endoplasmic reticulum exit sites (ERES) are specialized, ribosome-free ER subdomains that serve as dynamic portals for COPII-mediated export of proteins from the ER. Beyond…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Cell Host & Microbe : Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation   Résumé : Cadaverine is a polyamine produced by the gut microbiota with links to health and disease, notably inflammatory bowel disease (IBD). Here, we show that cadaverine shapes…

L'équipe Greenberg a publié une nouvelle revue dans Plos Genetics : Epigenetic relay: Polycomb-directed DNA methylation in mammalian development Résumé : In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of promoter 5-cytosine DNA methylation (5meC). Early mammalian development, however, is…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers Résumé : Branched actin networks nucleated by the Arp2/3 complex have critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90-family proteins, Arp2/3 nucleates linear actin…

L'équipe Ladoux/Mege a contribué à la publication d'un nouvel article dans Nature Communications : Capturing nematic order on tissue surfaces of arbitrary geometry   Résumé : A leading paradigm for understanding the large-scale behavior of tissues is via generalizations of liquid crystal physics; much like liquid crystals, tissues combine fluid-like, viscoelastic behaviors with local orientational order, such as nematic…

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans The European Physical Journal E : Probing protein–protein interactions with drag flow: a case study of F-actin and tropomyosin Résumé : Tropomyosins are central regulators of the actin cytoskeleton, controlling the binding and activity of the other actin binding proteins. The interaction between tropomyosin and actin is…

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nature Communications : UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells   Résumé : In mammals, primordial germ cells (PGCs) undergo global erasure of DNA methylation with delayed demethylation of germline genes and selective retention of DNA methylation at evolutionarily young retrotransposons. However, the molecular mechanisms…