L'équipe Ladoux/Mege a publié un nouvel article dans PNAS : Flocking and giant fluctuations in epithelial active solids Significance During embryonic development and wound healing, epithelial cells usually display in-plane polarity over large spatial scales and move coherently. However, most in vitro studies have examined the fluid-like chaotic dynamics of epithelial cells, in which collective cellular flows…

L'équipe Wassmann a publié un nouvel article dans Current Biology : Prolonged metaphase II arrest weakens Aurora B/C-dependent error correction in mouse oocytes   Résumé : Segregation errors in meiosis lead to aneuploid gametes and consequently to the development of trisomies, spontaneous abortion and fertility issues. Chromosome attachment to the microtubules of the bipolar spindle is a…

L'équipe Doye a contribué à la publication d'un nouvel article dans Nature cell biology : Nuclear pores safeguard the integrity of the nuclear envelope   Résumé : Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange, which is essential for eukaryotes. Mutations in the central scaffolding components of NPCs are associated with genetic diseases, but how they manifest only in specific…

L'équipe Ribes/Nedelec a contribué à la publication d'un nouvel article dans Nature Communications : A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification   Résumé : Studying ciliary genes in the context of the human central nervous system is crucial for understanding the underlying causes of neurodevelopmental ciliopathies. Here, we use…

L'équipe Palancade a contribué à la publication d'un nouvel article dans Nature communications : A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors Résumé : Small nucleolar RNAs are non-coding transcripts that guide chemical modifications of RNA substrates and modulate gene expression at the epigenetic and post-transcriptional levels. However, the extent…

L'équipe Romet-Lemonne / Jégou a contribué à la publication d'un nouvel article dans Cell : Genetically encoded reporters of actin filament organization in living cells and tissues   Résumé : The cytoskeletal protein actin is crucial for cell shape and integrity throughout eukaryotes. Actin filaments perform essential biological functions, including muscle contraction, cell division, and tissue morphogenesis. These…

L'équipe Ladoux/Mège a publié un nouvel article dans Nature material : Force transmission is a master regulator of mechanical cell competition Résumé : Cell competition is a tissue surveillance mechanism for eliminating unwanted cells, being indispensable in development, infection and tumourigenesis. Although studies have established the role of biochemical mechanisms in this process, due to challenges in…