L'équipe Palancade et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans PLOS Genetics : Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Abstract : Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome…

L'équipe Guichet a contribué à une nouvelle publication dans Journal of Evolutionary Biology : Sheltered load in fungal mating-type chromosomes revealed by fitness experiments Résumé : Sex chromosomes and mating-type chromosomes can carry large regions with suppressed recombination. As a result of a lower efficacy of selection, recessive deleterious mutations are expected to accumulate in these non-recombining…

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Epigenetics : PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation   Résumé : Genomic imprinting is the parent-of-origin specific monoallelic expression of genes that result from complex epigenetic interactions. It is often achieved by monoallelic 5-methylcytosine, resulting in the formation of differentially methylated regions…

L'équipe Ladoux-Mège, le laboratoire MSC et l'Institut Cochin ont publié en collaboration un nouvel article dans Biophysical Journal : The enteric nervous system is 10 times stiffer than the brain L’intestin est le seul organe de notre corps doté d’une innervation quasi-autonome, le système nerveux entérique, appelé communément le « second cerveau ». Le cerveau et à la…

L'équipe Romet-Lemonne/Jégou a publié une nouvelle publication dans PNAS : Continuous self-repair protects vimentin intermediate filaments from fragmentation Résumé : Intermediate filaments are key regulators of cell mechanics. Vimentin, a type of intermediate filament expressed in mesenchymal cells and involved in migration, forms a dense network in the cytoplasm that is constantly remodeling through filament transport, elongation/shortening,…

L'équipe Ladoux/Mège a contribué à la publication d'un nouvel article dans The European Physical Journal E : Osmotic pressure induces unexpected relaxation of contractile 3D microtissue   Résumé : Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…