L'équipe Greenberg a publié une nouvelle revue dans Plos Genetics : Epigenetic relay: Polycomb-directed DNA methylation in mammalian development Résumé : In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of promoter 5-cytosine DNA methylation (5meC). Early mammalian development, however, is…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers Résumé : Branched actin networks nucleated by the Arp2/3 complex have critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90-family proteins, Arp2/3 nucleates linear actin…

L'équipe Ladoux/Mege a contribué à la publication d'un nouvel article dans Nature Communications : Capturing nematic order on tissue surfaces of arbitrary geometry   Résumé : A leading paradigm for understanding the large-scale behavior of tissues is via generalizations of liquid crystal physics; much like liquid crystals, tissues combine fluid-like, viscoelastic behaviors with local orientational order, such as nematic…

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans The European Physical Journal E : Probing protein–protein interactions with drag flow: a case study of F-actin and tropomyosin Résumé : Tropomyosins are central regulators of the actin cytoskeleton, controlling the binding and activity of the other actin binding proteins. The interaction between tropomyosin and actin is…

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nature Communications : UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells   Résumé : In mammals, primordial germ cells (PGCs) undergo global erasure of DNA methylation with delayed demethylation of germline genes and selective retention of DNA methylation at evolutionarily young retrotransposons. However, the molecular mechanisms…

L'équipe Wassmann a publié un nouvel article dans EMBO : Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II Abstract : The meiotic segregation pattern to generate haploid gametes is mediated by step-wise cohesion removal by separase, first from chromosome arms in meiosis I, and then from the pericentromere in meiosis II. In…

L'équipe Minc a contribué à la publication d'un nouvel article dans Biophysical Journal : Inferring diffusion, reaction, and exchange parameters from imperfect FRAP Résumé : Fluorescence recovery after photobleaching (FRAP) is broadly used to investigate the dynamics of molecules in cells and tissues, notably to quantify diffusion coefficients. FRAP is based on the spatiotemporal imaging of fluorescent…

L'équipe Ribes/Nedelec a contribué à la publication d'un nouvel article dans Science Advances : GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration   Résumé : The saltatory migration of neurons is essential for brain formation. Whether mechanical stimuli regulate this process is unknown. Here, we show that the primary cilium acts as a mechanical sensor through…