La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Communication Biology : Myocardial disarray drives metabolic inefficiency in human cardiomyocytes   Résumé : Adult cardiomyocytes are embedded within a highly organized myocardial microenvironment that imposes critical geometric cues essential for the alignment and distribution of organelles and the shaping of their unique, rectangular cellular morphology.…

L'équipe Raote a contribué à la publication d'un nouvel article dans Nature reviews molecular cell biology : Towards a unified framework for the function of endoplasmic reticulum exit sites Résumé : Endoplasmic reticulum exit sites (ERES) are specialized, ribosome-free ER subdomains that serve as dynamic portals for COPII-mediated export of proteins from the ER. Beyond…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Cell Host & Microbe : Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation   Résumé : Cadaverine is a polyamine produced by the gut microbiota with links to health and disease, notably inflammatory bowel disease (IBD). Here, we show that cadaverine shapes…

L'équipe Greenberg a publié une nouvelle revue dans Plos Genetics : Epigenetic relay: Polycomb-directed DNA methylation in mammalian development Résumé : In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of promoter 5-cytosine DNA methylation (5meC). Early mammalian development, however, is…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers Résumé : Branched actin networks nucleated by the Arp2/3 complex have critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90-family proteins, Arp2/3 nucleates linear actin…

L'équipe Ladoux/Mege a contribué à la publication d'un nouvel article dans Nature Communications : Capturing nematic order on tissue surfaces of arbitrary geometry   Résumé : A leading paradigm for understanding the large-scale behavior of tissues is via generalizations of liquid crystal physics; much like liquid crystals, tissues combine fluid-like, viscoelastic behaviors with local orientational order, such as nematic…

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans The European Physical Journal E : Probing protein–protein interactions with drag flow: a case study of F-actin and tropomyosin Résumé : Tropomyosins are central regulators of the actin cytoskeleton, controlling the binding and activity of the other actin binding proteins. The interaction between tropomyosin and actin is…