L'équipe Léon a publié, en collaboration avec la plateforme ProtéoSeine, un nouvel article dans Plos Genetics : A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition   Résumé : The yeast Saccharomyces cerevisiae thrives in sugar-rich environments by rapidly consuming glucose and favoring alcoholic fermentation. This strategy is tightly regulated by the glucose…

La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Communication Biology : Myocardial disarray drives metabolic inefficiency in human cardiomyocytes   Résumé : Adult cardiomyocytes are embedded within a highly organized myocardial microenvironment that imposes critical geometric cues essential for the alignment and distribution of organelles and the shaping of their unique, rectangular cellular morphology.…

L'équipe Raote a contribué à la publication d'un nouvel article dans Nature reviews molecular cell biology : Towards a unified framework for the function of endoplasmic reticulum exit sites Résumé : Endoplasmic reticulum exit sites (ERES) are specialized, ribosome-free ER subdomains that serve as dynamic portals for COPII-mediated export of proteins from the ER. Beyond…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Cell Host & Microbe : Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation   Résumé : Cadaverine is a polyamine produced by the gut microbiota with links to health and disease, notably inflammatory bowel disease (IBD). Here, we show that cadaverine shapes…

L'équipe Greenberg a publié une nouvelle revue dans Plos Genetics : Epigenetic relay: Polycomb-directed DNA methylation in mammalian development Résumé : In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of promoter 5-cytosine DNA methylation (5meC). Early mammalian development, however, is…

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans Nature structural & molecular biology : Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers Résumé : Branched actin networks nucleated by the Arp2/3 complex have critical roles in various cellular processes, from cell migration to intracellular transport. However, when activated by WISH/DIP/SPIN90-family proteins, Arp2/3 nucleates linear actin…