L'équipe Veitia a publié un nouvel article dans FASEB Journal : Nonlinearities and Switch-Like Behavior in Gene Expression: From Genetics to Biochemistry and Back. Résumé : Many developmental and physiological outcomes depend on transcriptional thresholds or switches. The transcriptional output, ultimately measured as mature RNA, is determined by a series of molecular steps that can introduce thresholds,…

L'équipe Prioleau a publié un nouvel article dans The FEBS Journal : Ploidy-dependent modulation of DNA replication kinetics in Xenopus Résumé : An important question in cell biology is how DNA replication programs scale with genome size following polyploidization, an evolutionary process that increases DNA content without proportionally extending the cell cycle duration. In particular, comparative…

L'équipe Ladoux/Mège a publié un nouvel article dans Molecular Biology of the Cell : Vimentin bridges scales to convert polarized cell locomotion into coordinated collective migration Résumé : Collective cell migration is central in development and disease. Vimentin is an intermediate filament protein expressed by epithelial cells at the edge of wounds where collective cell migration is…

L'équipe Guichet a publié un nouvel article dans mBio : Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina Résumé : Nuclear movement, positioning, and the mechanical constraints applied to the nucleus play important roles in cellular identity, physiology, and gene regulation. This process, known…

L'équipe Veitia a publié un nouvel article dans FASEB Journal : Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs Résumé : FOXL2 is a forkhead transcription factor (TF) essential for granulosa-cell identity and function, yet how post-translational modifications tune its activity remains incompletely…

L'équipe Guichet a contribué à la publication d'un nouvel article dans Biochimica et Biophysica Acta (BBA) - Molecular Cell Research : Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina Abstract Microtubule-based organelle…

L'équipe Romet-Lemonne/Jégou a publié un nouvel article dans PNAS : Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end Résumé : Significance The cytoskeleton is composed of three types of filaments: actin, microtubules, and intermediate filaments, which coordinate to control cell shape, mechanics, and movement. Among them, the contribution of vimentin intermediate filaments to…

La plateforme ImagoSeine a contribué à la publication d'un nouvel article dans Biomacromolecules : Nanoscale Structural Insights into Human Pulmonary Mucus and Its Snail Slime-Based Surrogate Using Automated TEM Image Processing Résumé : Pulmonary drug delivery is a promising approach for treating respiratory diseases, but the mucus barrier in bronchial airways often hinders therapeutic efficacy.…