L'équipe Ladoux/Mege a publié un nouvel article dans Soft Matter : Radical scaling: beyond our feet and fingers Résumé : Scaling laws arise and are eulogized across disciplines from natural to social sciences for providing pithy, quantitative, ‘scale-free’, and ‘universal’ power law relationships between two variables. On a log–log plot, the power laws display as straight lines,…

L'équipe Wassmann a publié un nouvel article dans EMBO Reports : Oocyte selection: a tale of individualism, dominance and sacrifice Résumé : Oocyte development is a fierce competitive process in which only a small fraction of germ cells survives massive waves of cell death to become a fertilizable egg. Using an ex vivo 4D imaging…

L'équipe Borghi a contribué la publication d'un nouvel article dans Microbiological Research : Chlamydia trachomatis highjacks host MYO1C for actin cage recruitment at the bacterial inclusion Résumé : Chlamydia trachomatis (Ct), a Gram-negative obligate intracellular pathogen, manipulates host actin dynamics to facilitate its entry, development, and exit. It assembles a dynamic actin cage around its intracellular niche,…

L'équipe Borghi a contribué à la publication d'un nouvel article dans Nature communications : Meningococci drive host membrane tubulation to recruit their signaling receptors Résumé : Once passed into the bloodstream, bacterial pathogens have a limited time to interact with permissive receptors at the surface of host cells. Neisseria meningitidis has developed an extremely effective strategy allowing it to find its…

L'équipe Pintard a publié un nouvel article dans The Journal of Cell biology : Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis Résumé : Microtubule-severing enzymes are evolutionarily conserved AAA-ATPases that sever microtubules, thereby regulating diverse microtubule-dependent cellular processes. How these enzymes couple Microtubule binding with ATP hydrolysis to trigger microtubule-remodeling remains poorly understood.…

L'équipe Veitia a publié un nouvel article dans Molecular & Cellular Proteomics : Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model.   Résumé : Background Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. This study…

L'équipe Ladoux/Mège a publié un nouvel article dans PNAS : Regulation of epithelial tissue homeostasis by active transepithelial transport Résumé : Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties of extracellular matrix, a interesting mechanobiological paradigm highlights the role of…