L'équipe Ladoux/Mège a publié un nouvel article dans Science Advances:  Cytoplasmic crowding drives intracellular viscoelastic increase during epithelial maturation Résumé : The cytoplasm is a crowded, active medium whose mechanical properties underpin essential cellular functions, yet how intracellular rheology adapts during tissue maturation remains unclear. Here, we examine the evolution of cytoplasmic viscoelasticity in Madin-Darby canine…

La plateforme ProtéoSeine a contribué à un nouvel article publié dans Journal of Hazardous Material : CBP inhibition and histone H3K18 hypoacetylation induced by the hematotoxic benzene metabolite 1,4-benzoquinone   Résumé : Benzene (BZ) is a pervasive environmental and occupational carcinogen whose leukemogenicity depends on metabolic activation into reactive intermediates, notably 1,4-benzoquinone (BQ). While genotoxic effects such as…

L'équipe Gazave a publié un éditorial dans BMC Biology : The brilliant future of non-traditional model organisms in biology Gazave E, Hampl V, E Podrabsky J, Whitworth D. The brilliant future of non-traditional model organisms in biology. BMC Biol. 2026 Oct 26;24(1):224. doi: 10.1186/s12915-026-02770-w. PMID: 42934738; PMCID: PMC13700528.  

L'équipe Veitia a publié un article dans Advanced Biology : AND Gates as Sources of Biological Nonlinearity: Relevance to Genetic Dominance Résumé : AND-gating is a mechanism capable of generating nonlinear biological responses because a productive output requires the joint satisfaction of several necessary molecular events. AND gates are considered here in the context of gene expression.…

L'équipe Minc a publié un nouvel article dans Biophysical Journal : Mechanical properties of chiral helical polymers: From single filaments to actin bundles Résumé : The mechanical properties of biological polymers are essential to their biological functions. Here, we introduce a highly coarse-grained model of helical filaments that preserves helicity and chirality while enabling mesoscale simulations.…

L'équipe Gazave a publié un nouvel article dans Cellular and Molecular Life Sciences : Understanding ROS signaling and evolution during animal regeneration offers promising opportunities for novel therapeutic approaches Résumé : Despite their potentially harmful oxidative properties, Reactive Oxygen Species (ROS) have been harnessed by living organisms during evolution as signaling molecules involved in various physiological processes.…

L'équipe Gazave a publié un nouvel article dans British Journal for the Philosophy of Science : The Identity of Stem Cell Kinds Résumé : Stem cells are defined by their self-renewal and differentiation abilities. Through those properties, they ensure the production and renewal of organisms’ cells and, in some species, the regeneration of lost parts, making them…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans FASEB Journal : Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra-Nuclear Signaling to Modulate Human Granulosa Cell Growth Résumé : Estradiol (E2) regulates ovarian follicular development and granulosa cell (GC) function primarily through estrogen receptor β (ERβ). Human GCs express several ERβ isoforms, including…

L'équipe Conduit a publié un nouvel article dans Journal of Cell Biology : A structural model for the autoinhibition of the γ-TuRC–activating CM1 domain Résumé : Microtubule nucleation by γ-tubulin ring complexes (γ-TuRCs) must be spatiotemporally controlled to avoid major cell division errors. γ-TuRCs are activated by the centrosome-specific binding of a highly conserved centrosomin motif 1…