General information
Offer title : PhD in cell biology (M/F) (H/F)
Reference : UMR7592-JULAZI-004
Number of position : 1
Workplace : PARIS 13
Date of publication : 07 November 2025
Type of Contract : FTC PhD student / Offer for thesis
Contract Period : 36 months
Start date of the thesis : 1 February 2026
Proportion of work : Full Time
Remuneration : 2200 € gross monthly
Section(s) CN : 22 – Cellular biology, development, evolution-development, reproduction
Apply on the CNRS job portal before November 28th
Description of the thesis topic
The thesis project aims to characterise a connector between the two centrioles of the centrosome that forms specifically in cells with a primary cilium, enabling the centrioles to be positioned correctly in these cells. The objective of the project is to determine the molecular architecture of the connector and the mechanisms that regulate its assembly, and to identify its functions. This will involve the use of expansion microscopy in combination with other super-resolution microscopy approaches such as STED, and molecular biology approaches (CRISPR/Cas9, RNAi), in a human cell culture model. The function of this structure in developmental processes will also be addressed in zebrafish as part of a collaboration. The candidate must have a Master’s degree in cell biology and expertise in super-resolution microscopy.
Work Context
The PhD student will be a member of the ‘Biogenesis and polarity of centrioles and cilia’ team led by Juliette Azimzadeh at the Jacques Monod Institute (UMR7592 Université Paris Cité – CNRS). The team uses cellular biology approaches, in particular super-resolution microscopy. The Institut Jacques Monod is a joint research unit of Université Paris Cité and CNRS with approximately 300 staff members. The institute is located on the Paris Rive Gauche campus in the 13th arrondissement of Paris.
Constraints and risks
In accordance with the internal regulations of the Jacques Monod Institute.