Séminaire de l’Institut Jacques Monod – Prof. Chwee Teck Lim
Invité par l’équipe Ladoux/Mège, Prof. Chwee Teck Lim ( Mechanobiology Institute, National University of Singapore ) présentera un séminaire de l’Institut Jacques Monod sur le thème :
How Geometry Drives Collective Cell Migration
Résumé : Cells that migrate as sheets or large cohorts exhibit behaviors that differ markedly from those of individually migrating cells, particularly when subjected to geometric constraints, physical confinement, or out-of-plane topography. Collective cell migration underlies many essential biological processes, including wound healing, maintenance of the intestinal epithelium, embryonic development, and cancer invasion and metastasis. Understanding these collective behaviors therefore offers valuable insights into tissue repair mechanisms and the design of regenerative medicine strategies. Here, we investigate the kinematic properties of collectively migrating cell cohorts under a range of well-defined geometric and physical constraints, including migration along narrow strips and across out-of-plane curved surfaces, to elucidate how confinement and surface geometry shape collective cell dynamics.
Bio : Professor Lim is the NUS Society Chair Professor and Director of the Institute for Health Innovation and Technology at NUS. He is also the Founding Director of the Singapore Health Technologies Consortium.
His research interests include human disease mechanobiology and the development of microfluidic and wearable technologies for healthcare applications. He is a prolific researcher having co-authored over 500 journal publications and delivered more than 550 plenary/keynote/invited lectures. He is also a serial entrepreneur having started six companies with one public listed in 2018.
Professor Lim is an Elected Fellow of the Royal Society (UK), Royal Academy of Engineering (UK), National Academy of Inventors (US), IUPESM, AIMBE, IAMBE, ASEAN Academy of Engineering and Technology, Academy of Engineering, Singapore, Singapore National Academy of Science and the Institution of Engineers. He and his team have garnered over 100 research awards and honours including the President’s Science Award, Otto Schmitt Award, Nature Lifetime Achievement Award for Mentoring in Science, Asia’s Most Influential Scientist, Highly Cited Researcher, IES Prestigious Engineering Achievement Award, ASEAN Outstanding Engineering Achievement Award, Asian Scientists 100, Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold), President’s Technology Award, and the Distinguished Alumni Award among others.