IJM News since 2010
Marc-Antoine Fardin researcher in the Cell and Mechanical Membership team at the IJM received the Ig Nobel Prize for Physics for his study, "Can a Cat Be Both Solid and Liquid" at the 27th Annual Harvard University Ig Nobel Prize in Cambridge, Massachusetts, USA September 14, 2017. The Ig Nobel Prizes honor achievements that first make people laugh, and then make them think. The prizes are intended to celebrate the unusual, honor the imaginative — and spur people's interest in science, medicine, and technology.
September 2017: A Specific epigenetic mark involved for DNA replication initiation in heterochromatin
The duplication of the genome is essential to ensure the fidelity of the transmission of genetic heritage of the cell following thr cell divisions. DNA replication occurs during the S-phase and begins at thousands of chromosomal sites along the genome in order to allow the correct and faithful duplication. The international association of three teams including the “Pathology of DNA replication” under the leadership of Jean-Charles Cadoret and Giuseppe Baldacci investigates the functions of H4K20 methylation and the associated H4K20 enzymes in the regulation of DNA replication. This work is published in The EMBO Journal and shows, for the first time, the particular role of a specific epigenetic mark in the temporal control of replication initiation process in heterochromatin.
Within the non-coding fraction of genomes, “introns” are DNA sequences that are transcribed into RNA, then removed, without obvious functions in several situations. By combining genomics and molecular biology in distinct yeast species and in human cells, an international team, leaded by Benoit Palancade at Institut Jacques Monod, has revealed that these sequences counteract the formation of genotoxic DNA-RNA hybrids (or “R-loops”). This study is published in this month issue of Molecular Cell.
In an article published on 19 june in the journal Nature Ecology & Evolution, the “Epigenome and Paleogenome » group of the Jacques Monod Institute has studied the DNA preserved in cat remains from the last 10,000 years originating from Europe, southwest Asia and Africa and reconstructed the history of the interactions between humans and cats during their domestication.
The Institut Jacques Monod invites renowned scientists to give seminars of wide biological interest. The next Monod Diderot Conferences will be given by Stanislav Dusko EHRLICH on Monday 10 July, 2017
June 2017: Crystal structure of Sen1, the orthologue of human senataxin, a helicase associated with two neurodegenerative diseases
In a study published this month in the EMBO journal and coordinated by Odil Porrua (Libri team) in collaboration with the group of Elena Conti (Max Planck Institute of Biochemistry, Germany), the authors present a structure-function analysis of the yeast homologue of senataxin, Sen1, which they use as a model to understand the molecular effect of senataxin mutations associated with neurological disorders.
June 2017: Discovery of a novel DNA repair system : Guanine glycation repair by Parkinsonism-associated protein DJ-1/Park7
This work is published in Science and was performed by Gilbert Richarme and his collaborators from the Institut Jacques Monod, CNRS, and universities Paris-Diderot, Paris-Descartes, Paris-Sud and from the Harvard Medical School.
In an article published on 27 April in the journal Nature Communications, the Guichet team at the Jacques Monod Institute shows that the asymmetric positioning of the nucleus is ensured by microtubules through two different molecular mechanisms that guarantee the robustness of the process
In an article published on May 3rd in the Journal of Cell Biology, the group of Sébastien Léon (Institut Jacques Monod) revealed a new mechanism that controls the degradation of cell surface sugar transporters. This process requires a protein called Csr2 that belongs to the arrestin protein family. Csr2 is regulated at multiple levels by glucose availability.
In an article published in the May 1st issue of Development, the Dumont team at the Institute Jacques Monod showed that an essential function of the kinesin-13 is to prevent ectopic microtubule assembly, when centrosome activity is low or absent, to avoid spindle disorganization and aneuploidy.