IJM News since 2010
The Institut Jacques Monod invites renowned scientists to give seminars of wide biological interest. The next Monod Diderot Conferences will be given by Stanislav Dusko EHRLICH on Monday 10 July, 2017
June 2017: Crystal structure of Sen1, the orthologue of human senataxin, a helicase associated with two neurodegenerative diseases
In a study published this month in the EMBO journal and coordinated by Odil Porrua (Libri team) in collaboration with the group of Elena Conti (Max Planck Institute of Biochemistry, Germany), the authors present a structure-function analysis of the yeast homologue of senataxin, Sen1, which they use as a model to understand the molecular effect of senataxin mutations associated with neurological disorders.
June 2017: Discovery of a novel DNA repair system : Guanine glycation repair by Parkinsonism-associated protein DJ-1/Park7
This work is published in Science and was performed by Gilbert Richarme and his collaborators from the Institut Jacques Monod, CNRS, and universities Paris-Diderot, Paris-Descartes, Paris-Sud and from the Harvard Medical School.
In an article published on 27 April in the journal Nature Communications, the Guichet team at the Jacques Monod Institute shows that the asymmetric positioning of the nucleus is ensured by microtubules through two different molecular mechanisms that guarantee the robustness of the process
In an article published on May 3rd in the Journal of Cell Biology, the group of Sébastien Léon (Institut Jacques Monod) revealed a new mechanism that controls the degradation of cell surface sugar transporters. This process requires a protein called Csr2 that belongs to the arrestin protein family. Csr2 is regulated at multiple levels by glucose availability.
In an article published in the May 1st issue of Development, the Dumont team at the Institute Jacques Monod showed that an essential function of the kinesin-13 is to prevent ectopic microtubule assembly, when centrosome activity is low or absent, to avoid spindle disorganization and aneuploidy.
The Institut Jacques Monod invites renowned scientists to give seminars of wide biological interest. The next Monod Diderot Conferences will be given by Stephan GRILL on Tuesday 23 May, 2017
Climate change and human-induced habitat reduction threaten many animal species with extinction. To better preserve remaining pocket populations, it is useful to know about their genetic relationships in the past when the species was thriving. Indeed, when populations are fragmented, gene flow between them is reduced. There is then a tendency for local phenotypic variations to be interpreted in terms of specific characters and to assign each population to a different species. As a consequence, management strategies often aim at preserving their identity by preventing gene flow between the present-day populations. Genetic analysis of past populations reveals their phylogenetic relationships and prior genetic exchanges, leading to better informed conservation strategies.
In an article published on 13 April in Nature, the team of Benoit Ladoux and René-Marc Mège in collaboration with scientists the Mechanobiology Institute (Singapore), National University of Singapore, from Oxford University (UK) and Institut Curie (France) have found that the major factor driving cell death and removal relies on the physical arrangement of cells in the surrounding cell layer. In particular, the appearance of defects in the cellular patterns of epithelial layers promotes cell death and elimination from the tissues.
The Institut Jacques Monod invites renowned scientists to give seminars of wide biological interest. The next Monod Diderot Conferences will be given by David SHORE on Thursday 22 June, 2017