IJM News since 2010
The team of Reiner Veitia at the Jacques Monod Institute (UMR CNRS Paris Diderot University) in collaboration with that of M. Misrahi of Paris-Sud University discovers a mutation in a gene, which leads to an early menopause. This pathology affects 1% of women under 40 years of age and results most often in infertility. Despite recent advances, the causes of this pathology are unknown in most cases.
December 2017: High resolution movies of the development of the segmented marine worm Platynereis, from egg to larva
In a manuscript published in eLife, Duygu Özpolat, a post-doc researcher of the group "Evolution and Development of Metazoans", in collaboration with a team of the Max Planck Institute Dresden, has shot movies of embryos and larvae of the annelid worm. Duygu has followed the divisions and fates of individual cells and established the cellular origin of the segmented organization of the worm.
In an article published on November in Nature Communications, the team of Benoit Ladoux and René-Marc Mège in collaboration with researchers from the Mechanobiology Institute (Singapore) has shown how epithelial cells can respond to the physical confinement of microtubular structures.
November 2017: Prices for the best oral presentation and « coup de cœur des donateurs » of the ARC fondation
Djihad HADJADJ, PhD student at the Jacques Monod institute in the team « DNA Replication Pathologies » has been awarded the best oral presentation price by the BioSPC doctoral school during a congress on the 9th-10th of november. He obtained a second price during the 21st « journées jeunes chercheurs de l’ARC sur l’oncologie » held on the 16th and 17th of november.
In an article published online on November 14th in Nature Communications, Kimberley Laband in the Dumont team shed light on an atypical chromosome segregation mechanism essential for functional oocyte production in C. elegans.
Amandine Molliex, postdoc at Institut Jacques Monod is laureate for L’Oréal-UNESCO For Women in Science Fellowships 2017.The L’Oréal Foundation gave 30 young female scientists with an excellent record a grant (15,000€ for doctoral researchers and 20,000€ for postdoctoral researchers) to help them at a pivotal time in their career.
Marc-Antoine Fardin researcher in the Cell and Mechanical Membership team at the IJM received the Ig Nobel Prize for Physics for his study, "Can a Cat Be Both Solid and Liquid" at the 27th Annual Harvard University Ig Nobel Prize in Cambridge, Massachusetts, USA September 14, 2017. The Ig Nobel Prizes honor achievements that first make people laugh, and then make them think. The prizes are intended to celebrate the unusual, honor the imaginative — and spur people's interest in science, medicine, and technology.
September 2017: A Specific epigenetic mark involved for DNA replication initiation in heterochromatin
The duplication of the genome is essential to ensure the fidelity of the transmission of genetic heritage of the cell following thr cell divisions. DNA replication occurs during the S-phase and begins at thousands of chromosomal sites along the genome in order to allow the correct and faithful duplication. The international association of three teams including the “Pathology of DNA replication” under the leadership of Jean-Charles Cadoret and Giuseppe Baldacci investigates the functions of H4K20 methylation and the associated H4K20 enzymes in the regulation of DNA replication. This work is published in The EMBO Journal and shows, for the first time, the particular role of a specific epigenetic mark in the temporal control of replication initiation process in heterochromatin.
Within the non-coding fraction of genomes, “introns” are DNA sequences that are transcribed into RNA, then removed, without obvious functions in several situations. By combining genomics and molecular biology in distinct yeast species and in human cells, an international team, leaded by Benoit Palancade at Institut Jacques Monod, has revealed that these sequences counteract the formation of genotoxic DNA-RNA hybrids (or “R-loops”). This study is published in this month issue of Molecular Cell.
In an article published on 19 june in the journal Nature Ecology & Evolution, the “Epigenome and Paleogenome » group of the Jacques Monod Institute has studied the DNA preserved in cat remains from the last 10,000 years originating from Europe, southwest Asia and Africa and reconstructed the history of the interactions between humans and cats during their domestication.