IJM News since 2010
January 2018: A hypothesis-driven approach identifies CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas
The “Pathology of DNA replication” group of the Institute Jacques Monod (UMR University Paris Diderot-Paris 7 and CNRS) proposes two Food and Drug Administration-authorized CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas. This work has been published in the journal "Aging" and featured on the cover of the December 2017 issue.
January 2018: How a mechanotransduction crosstalk between cell adhesion complexes results in ß-catenin pathway activation
ß-catenin is a major transcription co-factor proposed to be released from E-cadherin upon mechanically induced phosphorylation. However, evidence for this mechanism is lacking. In an article published in the Journal of Cell Biology online on January 8, 2018, the team of Nicolas Borghi shows instead that during Epithelial-to-Mesenchyme Transition, Src- and multicellular confinement-dependent FAK-induced cytoskeleton remodeling causes E-cadherin tension relaxation and phosphorylation-independent ß-catenin nuclear translocation from the membrane.
This new program, started in 2017 by CNRS, aims at rewarding talented young scientists, allowing them to independently lead an innovating research activity integrated in a CNRS team. Serge DMITRIEFF, researcher in the team "Cellular spatial organisation" in Institut Jacques Monod, was awarded a CNRS-Momentum fellowship for his project on self organisation of cell polarity and growth.
A group of researchers from the Institute Jacques Monod at the University Paris Diderot-CNRS and from Baylor College of Medecine at Houston (USA), supervised by Professeur Marc Nadal, showed for the first time that an enzyme performing the cleavage of only one DNA strand, is able to achieve chromosomes separation on its own. This work has been published for the month of december 2017 in the journal « Nucleic Acids Research »
The team of Reiner Veitia at the Jacques Monod Institute (UMR CNRS Paris Diderot University) in collaboration with that of M. Misrahi of Paris-Sud University discovers a mutation in a gene, which leads to an early menopause. This pathology affects 1% of women under 40 years of age and results most often in infertility. Despite recent advances, the causes of this pathology are unknown in most cases.
December 2017: High resolution movies of the development of the segmented marine worm Platynereis, from egg to larva
In a manuscript published in eLife, Duygu Özpolat, a post-doc researcher of the group "Evolution and Development of Metazoans", in collaboration with a team of the Max Planck Institute Dresden, has shot movies of embryos and larvae of the annelid worm. Duygu has followed the divisions and fates of individual cells and established the cellular origin of the segmented organization of the worm.
In an article published on November in Nature Communications, the team of Benoit Ladoux and René-Marc Mège in collaboration with researchers from the Mechanobiology Institute (Singapore) has shown how epithelial cells can respond to the physical confinement of microtubular structures.
November 2017: Prices for the best oral presentation and « coup de cœur des donateurs » of the ARC fondation
Djihad HADJADJ, PhD student at the Jacques Monod institute in the team « DNA Replication Pathologies » has been awarded the best oral presentation price by the BioSPC doctoral school during a congress on the 9th-10th of november. He obtained a second price during the 21st « journées jeunes chercheurs de l’ARC sur l’oncologie » held on the 16th and 17th of november.
In an article published online on November 14th in Nature Communications, Kimberley Laband in the Dumont team shed light on an atypical chromosome segregation mechanism essential for functional oocyte production in C. elegans.
Amandine Molliex, postdoc at Institut Jacques Monod is laureate for L’Oréal-UNESCO For Women in Science Fellowships 2017.The L’Oréal Foundation gave 30 young female scientists with an excellent record a grant (15,000€ for doctoral researchers and 20,000€ for postdoctoral researchers) to help them at a pivotal time in their career.