IJM News since 2010
In an article published on April 23rd, and featured on the cover of Developmental Cell, the team Minc at Institut Jacques Monod establishes a new live imaging method to study the dynamics of cell wall assembly in living cells.
Lipid droplets (LDs) are essential cellular organelles, but how proteins that regulate LD function are targeted to this compartment is poorly understood. In an article by Copic et al., published on April 6 in Nature Communications, the Jackson-Verbavatz team has used a remarkable LD protein, perilipin 4, as a model to study how proteins interact with LDs. They demonstrate both in vitro and in cells that the extremely long amphipathic helix of perilipin 4 can directly bind to the neutral lipid core of LDs, acting as a coat that prevents unregulated LD growth.
Nicolas MINC is leader of the group “Cellular Spatial Organization” at the Institut Jacques Monod
Sadly, our colleague Françoise Poirier passed away on March 2, 2018, after a long illness. On behalf of the members of the Institut Jacques Monod, we convey our deepest condolences to her husband Roger Karess, Deputy Director of the institute, and to their children Elodie and Gabriel.
The Institut Jacques Monod (IJM), a leading center of fundamental biological research in Paris, is seeking to appoint several new group leaders. The IJM is comprised of about 30 research groups working in the fields of genetics and genomics, biophysics, cell biology, development and evolution.
Mitochondrial diseases result from a dysfunction of mitochondria. Such organelles are responsible for providing more than 90% of the energy required by our organs to support life. In case of failure, the energy generated is not enough and leads to disorders ranging from exercise intolerance to an overt disease. The organs that have a great energy demand, such as the heart, brain or the muscles, are the most affected ones. Mitochondrial diseases are often hard to diagnose, because they affect each individual differently. Symptoms can include developmental delay, intellectual disability, seizures, inability to walk, talk, see, and other complications. Mitochondrial diseases may be caused by alterations of the mitochondrial genome. R. Veitia, from the Molecular Oncology and Ovarian Pathologies Team, has proposed a mathematical model which might be useful to predict the effects of the most common mitochondrial DNA mutation. This work has just been published (20/02/2018) in Human Molecular Genetics.
In all organisms, RNA polymerases transcribe a much larger fraction of the genome than that occupied by known genes. The function and the impact of this “pervasive” transcription on the stability and expression of genomes are intensely studied in many laboratories. Researchers at the Institute Jacques Monod have shown that many RNA polymerases do not stop at the end of the genes they transcribe, and contribute significantly to pervasive transcription. However, their spreading beyond genes is limited: elongating polymerases hit obstacles to their progression due to several factors or complexes bound to the DNA, which restricts the “invasion” of regions “sensitive” to transcription. This work has been published online on January 19th in the EMBO journal.
January 2018: A study produced in the IJM among the ten discoveries of 2017 according to the French science magazine La Recherche
The work of the Epigenome & Paleogenome team on the palaeogenetics of cat dispersal in the ancient world published in 2017 in Nature Ecology & Evolution has been selected by the French science magazine La Recherche among the ten scientific discoveries of 2017.
The team of Françoise Poirier and Mireille Viguier at the Jacques Monod Institute showed that a small soluble protein, called galectin-7, controls the stability of adherent junctions present at contacts between neighboring cells. Galectin-7 thus allows a better efficiency during collective cell migration. This work was published on December 6, 2017 in the journal Scientific Reports.
La plateforme " Protéomique Structurale et Fonctionnelle " de l'IJM vient de recevoir la labellisation IBiSA délivrée par le GIS " Infrastructures en Biologie Santé et Agronomie " (https://www.ibisa.net/). Cette labellisation s'accompagne d'une dotation financière pour permettre le développement des approches protéomiques quantitatives ciblées.