IJM News since 2010
The Institut Jacques Monod (IJM), a leading center of fundamental biological research in Paris, is seeking to appoint several new group leaders. The IJM is comprised of about 30 research groups working in the fields of genetics and genomics, biophysics, cell biology, development and evolution.
Mitochondrial diseases result from a dysfunction of mitochondria. Such organelles are responsible for providing more than 90% of the energy required by our organs to support life. In case of failure, the energy generated is not enough and leads to disorders ranging from exercise intolerance to an overt disease. The organs that have a great energy demand, such as the heart, brain or the muscles, are the most affected ones. Mitochondrial diseases are often hard to diagnose, because they affect each individual differently. Symptoms can include developmental delay, intellectual disability, seizures, inability to walk, talk, see, and other complications. Mitochondrial diseases may be caused by alterations of the mitochondrial genome. R. Veitia, from the Molecular Oncology and Ovarian Pathologies Team, has proposed a mathematical model which might be useful to predict the effects of the most common mitochondrial DNA mutation. This work has just been published (20/02/2018) in Human Molecular Genetics.
In all organisms, RNA polymerases transcribe a much larger fraction of the genome than that occupied by known genes. The function and the impact of this “pervasive” transcription on the stability and expression of genomes are intensely studied in many laboratories. Researchers at the Institute Jacques Monod have shown that many RNA polymerases do not stop at the end of the genes they transcribe, and contribute significantly to pervasive transcription. However, their spreading beyond genes is limited: elongating polymerases hit obstacles to their progression due to several factors or complexes bound to the DNA, which restricts the “invasion” of regions “sensitive” to transcription. This work has been published online on January 19th in the EMBO journal.
January 2018: A study produced in the IJM among the ten discoveries of 2017 according to the French science magazine La Recherche
The work of the Epigenome & Paleogenome team on the palaeogenetics of cat dispersal in the ancient world published in 2017 in Nature Ecology & Evolution has been selected by the French science magazine La Recherche among the ten scientific discoveries of 2017.
The team of Françoise Poirier and Mireille Viguier at the Jacques Monod Institute showed that a small soluble protein, called galectin-7, controls the stability of adherent junctions present at contacts between neighboring cells. Galectin-7 thus allows a better efficiency during collective cell migration. This work was published on December 6, 2017 in the journal Scientific Reports.
La plateforme " Protéomique Structurale et Fonctionnelle " de l'IJM vient de recevoir la labellisation IBiSA délivrée par le GIS " Infrastructures en Biologie Santé et Agronomie " (https://www.ibisa.net/). Cette labellisation s'accompagne d'une dotation financière pour permettre le développement des approches protéomiques quantitatives ciblées.
January 2018: A hypothesis-driven approach identifies CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas
The “Pathology of DNA replication” group of the Institute Jacques Monod (UMR University Paris Diderot-Paris 7 and CNRS) proposes two Food and Drug Administration-authorized CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas. This work has been published in the journal "Aging" and featured on the cover of the December 2017 issue.
January 2018: How a mechanotransduction crosstalk between cell adhesion complexes results in ß-catenin pathway activation
ß-catenin is a major transcription co-factor proposed to be released from E-cadherin upon mechanically induced phosphorylation. However, evidence for this mechanism is lacking. In an article published in the Journal of Cell Biology online on January 8, 2018, the team of Nicolas Borghi shows instead that during Epithelial-to-Mesenchyme Transition, Src- and multicellular confinement-dependent FAK-induced cytoskeleton remodeling causes E-cadherin tension relaxation and phosphorylation-independent ß-catenin nuclear translocation from the membrane.
This new program, started in 2017 by CNRS, aims at rewarding talented young scientists, allowing them to independently lead an innovating research activity integrated in a CNRS team. Serge DMITRIEFF, researcher in the team "Cellular spatial organisation" in Institut Jacques Monod, was awarded a CNRS-Momentum fellowship for his project on self organisation of cell polarity and growth.
A group of researchers from the Institute Jacques Monod at the University Paris Diderot-CNRS and from Baylor College of Medecine at Houston (USA), supervised by Professeur Marc Nadal, showed for the first time that an enzyme performing the cleavage of only one DNA strand, is able to achieve chromosomes separation on its own. This work has been published for the month of december 2017 in the journal « Nucleic Acids Research »