Le vendredi 5 avril 2024, le Labex WHO AM I? invite le Professeur Matthias Peter (Institute of Biochemistry, ETH Zurich) pour présenter une Conférence de l’Institut Jacques Monod (anciennement “Conférence Monod-Diderot”) sur le thème :
Protect and recycle: how cells regulate dormancy
Résumé :
Amyloids were long viewed as irreversible, pathological aggregates, often associated with neurodegenerative diseases. However, recent insights challenge this view, providing evidence that reversible amyloids form upon stress conditions and fulfil critical cellular functions. Yet, the molecular mechanisms regulating functional amyloids and the differences to their pathological counterparts remain poorly understood. In this talk, I will summarize conserved principles of amyloid reversibility that we uncovered by studying the essential metabolic enzyme pyruvate kinase (PK) in yeast and human cells. Indeed, both yeast Cdc19 and human PKM2, but not PKM1, form reversible amyloids through a pH-sensitive amyloid core motif. Stress-induced cytosolic acidification promotes aggregate formation via protonation of specific residues within the amyloid core. Our work thus unravels a conserved and potentially widespread molecular mechanism underlying amyloid functionality and reversibility, fine-tuned to the respective physiological pH range of cells.
La conférence se déroulera de 11h45 à 13h dans l’amphithéâtre Buffon, 15 rue Hélène Brion 75013 Paris
