L’équipe Wassmann a publié un nouvel article dans EMBO Reports :
Oocyte selection: a tale of individualism, dominance and sacrifice
Résumé :
Oocyte development is a fierce competitive process in which only a small fraction of germ cells survives massive waves of cell death to become a fertilizable egg. Using an ex vivo 4D imaging system, Zhang and colleagues discovered that individual oocytes actively move, extend filopodia-like protrusions, and engulf the debris of their dying neighbors to fuel their own growth (Zhang et al, 2025a). These findings reveal a previously unrecognized, phagocytosis-driven mechanism of oocyte selection that shapes the ovarian reserve.
Wassmann K. Oocyte selection: a tale of individualism, dominance and sacrifice. EMBO Rep. 2025 Dec 8. doi: 10.1038/s44319-025-00665-5. Epub ahead of print. PMID: 41361695.