Séminaire de l’Institut Jacques Monod – Olivier Destaing
Invité par l’équipe Ribes / Nedelec, Olivier Destaing (PhD-HDR (DR2 CNRS), Group INVADE à l’institut pour l’avancée des Biosciences UMR 5309 (CNRS, Inserm, UGA) ) présentera un séminaire de l’Institut Jacques Monod sur le thème :
Understanding specificity and redundancy in cell signaling. Let’s put a bit of light in SRC signaling
Résumé :
The discovery of the concept of homeostasis has highlighted the dynamic nature of biological systems at all scales, from the cell to the whole organism. Biological systems are characterized by their ability to maintain a dynamic equilibrium in response to sensing and adaptation to their environment. This property is based on intracellular signaling network able to detect, amplify and generate adapted cellular responses. Although classical approaches in biology, such as genetics and pharmacology, can modulate these systems, they are problematic to act both on time and space scales . The introduction of optogenetics has made possible to interact dynamically with biological systems on scales characteristic of these systems, ranging from seconds to days, and from micrometers to centimeters.
Our team has focused on developing methods, probes and optical systems to enable a wide range of optogenetic approaches aimed at controlling multiple and diverse biological functions. These causal approaches to biology are perfectly attuned to the characteristic timing of the targeted biological processes. In addition to previous collaborative works on mechanosensitive transcription factors or inflammatory organelles, we have recently proposed new molecular bases for basic principles of cell signaling, such as decision making or signal redundancy, in cancer and immune cells. To do, we focused on the interplays between SRC signaling kinases (SFKs) in the biology of epithelial cells and macrophages. These synthetic biology approaches can even beused for new approaches in biotechnology. Optogenetics is an approach for causal manipulation at multiple levels of biochemical regulation, enabling new conceptual interactions at the physics-biology interface.