Séminaire de l’Institut Jacques Monod – Can Aztekin

Invité par l’équipe Gazave, Can Aztekin (Friedrich Miescher Laboratory of the Max Planck Society) présentera un séminaire de l’Institut Jacques Monod :

Signaling centers of appendage regeneration: from single cells to species

Résumé :

Unlike mammals, Xenopus laevis tadpoles possess a remarkable ability to regenerate lost appendages. In our previous work (Aztekin et al., 2019, 2021), we identified key signaling center cell types that form during tail and limb regeneration. Through cross-species comparisons (Zhong et al., 2023), we have identified equivalent cell populations in mammals, and developed simplified stem cell-based models to investigate the properties of these regenerative cells (Skoufa et al., 2024). In this talk, I will present our findings on the critical genetic and environmental factors that influence signaling center formation in Xenopus tadpole and mouse embryonic limbs (Tsissios et al., 2024). These results shed light on the mechanisms underlying limb regeneration competence and provide insights into the divergent regenerative capabilities between species.