Séminaire de l’Institut Jacques Monod – Claire Chazaud

Invité par l’équipe Ribes / Nedelec, Claire Chazaud (DR INSERM, Institut GReD (CNRS/INSERM/Université-Clermont-Auvergne) présentera un séminaire de l’Institut Jacques Monod sur le thème :

The emergence of the mouse pluripotent epiblast

Résumé :

Our project is to understand the genetic mechanisms of cell lineage differentiation in the mouse embryo during preimplantation. We are particularly interested in the specification between epiblast cells (Epi) and primitive endoderm cells (PrE) which takes place during the first 3 days in mice, corresponding to the first 6 days in humans. The Epi cells produce all the cells of the future individual and its descendants and are the source of the famous pluripotent ES cells. Epi and PrE cells are specified from Inner Cell Mass (ICM) cells, and they express the transcription factors NANOG and GATA6, respectively, according to a salt and pepper pattern. How is this pattern is acquired has been the focus of our research, which highlights a combination of stochastic and deterministic mechanisms.