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DTSTART;TZID=Europe/Paris:20260918T114500
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DTSTAMP:20260715T132021Z
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SUMMARY:Séminaire de l'Institut Jacques Monod - Prof. Omaya Dudin
DESCRIPTION:Invité par l’équipe Dumont\, Prof. Omaya Dudin (Dpt. Biochemistry\, University of Geneva) présentera un séminaire de l’Institut Jacques Monod sur le thème : \nExploring multicellular developmental programs at the root of animals and beyond \nRésumé : \nAll animals develop from a single-celled zygote and undergo complex morphogenetic processes to form multicellular organisms. These processes are regulated by intrinsic and extrinsic factors that drive key developmental events\, such as symmetry breaking\, cell division\, and differentiation. Despite the remarkable conservation of these pathways across species\, the evolutionary origins of these morphogenetic mechanisms remain unclear. A major challenge in addressing this question is the limited availability of microscopy and cell biological data from key protists that occupy pivotal phylogenetic positions in the eukaryotic tree\, including those identified as the closest unicellular relatives of animals. \nIn this talk\, I will present how our lab is utilizing Expansion Microscopy to capture novel ultrastructural details of microbial life cycles. I will also share recent insights into Ichthyosporeans\, a lineage of protists closely related to animals\, which exhibit diverse multicellular development strategies. These include species that undergo coenocytic development followed by cellularization\, as well as others that develop through cleavage divisions to form spatially organized multicellular colonies. Our findings highlight the importance of studying diverse unicellular taxa to trace the origins of animal multicellularity\, positioning Ichthyosporeans as a promising model for exploring the evolutionary roots of animal embryogenesis.
URL:https://www.ijm.fr/event/seminaire-de-linstitut-jacques-monod-prof-omaya-dudin/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
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DTSTART;VALUE=DATE:20260921
DTEND;VALUE=DATE:20260926
DTSTAMP:20260327T153936Z
CREATED:20260327T133451Z
LAST-MODIFIED:20260327T153936Z
UID:32584-1789948800-1790380799@www.ijm.fr
SUMMARY:Conférence Jacques Monod - The mechanistic and evolutionary basis of programmed DNA elimination
DESCRIPTION:The Conférence Jacques Monod  » The mechanistic and evolutionary basis of programmed DNA elimination » will take place from Monday\, September 21\, 2026toFriday\, September 25\, 2026 in Roscoff (Bretagne\, France). \n\n\n\n\nAbstracts submission deadline : Tuesday\, May 5\, 2026\n\n\nDeadline for payment of registration fees : July 2\, 2026\n\n\nDeadline for return of completed forms : July 2\, 2026\n\n\n\n\n\n\nRegistration and abstract submission website  \n\n\n\nBeyond mutations\, the genetic content of an organism is generally constant across cells throughout development. Programmed DNA elimination (PDE) – a process in which specific cell lineages lose DNA segments or whole chromosomes – represents is a striking deviation to this principle. \n\nPDE is widespread in eukaryotes and plays roles in a variety of cellular processes\, including gene silencing\, germline differentiation\, genome defence\, and non-Mendelian inheritance. It manifests in diverse biological contexts\, including the formation of germline-limited genomes\, meiotic elimination of parental chromosomes\, and sex determination via X-chromosome loss. \nIn recent years\, it has become increasingly clear that PDE occurs across a wide range of phylogenetic groups\, and involves diverse mechanisms.  These findings underscore the overlooked plasticity of genome integrity\, and reveal significant gaps in our understanding of why PDE has evolved repeatedly and is maintained across the Tree of Life. \nThis conference is designed to present the latest research on the mechanisms and evolution of PDE – from the molecular pathways that control genome stability and chromosome segregation\, to genomic conflicts and the long-term evolutionary consequences of PDE on population dynamics and species diversification. We also welcome researchers studying related phenomena\, such as meiotic drive\, B chromosomes\, and those that work on the mechanisms and regulation of genome stability\, chromosome segregation and germline development. \nThe meeting will address the following key topics: \n\n Mechanisms and regulation of genome stability and instability\nMechanisms of chromosome segregation and missegregation\nGenomic conflicts\nEvolutionary dynamics of programmed DNA elimination
URL:https://www.ijm.fr/event/conference-jacques-monod-the-mechanistic-and-evolutionary-basis-of-programmed-dna-elimination/
LOCATION:Roscoff\, Roscoff\, France
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