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X-WR-CALDESC:Évènements pour Institut Jacques Monod
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DTSTART;VALUE=DATE:20260602
DTEND;VALUE=DATE:20260603
DTSTAMP:20260523T152151
CREATED:20260511T121056Z
LAST-MODIFIED:20260511T121230Z
UID:33032-1780358400-1780444799@www.ijm.fr
SUMMARY:22nd annual meeting of the Neural Network Development club
DESCRIPTION:La journée scientifique annuelle du Club de Développement des Réseaux Neuronaux a pour objectif de promouvoir les travaux des chercheurs de la communauté. Elle aura lieu le 2 juin 2026.  Le programme est construit sur la base des résumés soumis pour communications orales. Les communications\, en anglais\, seront réparties en trois sessions scientifiques\, intercalées avec les séminaires de conférenciers invités experts dans le domaine du neurodéveloppement. \nLes inscriptions pour la journée du club DRN sont ouvertes jusqu’au 19 mai 2026 via le site de l’évènement.  \nL’inscription est obligatoire pour pouvoir participer aux conférences \nLe club Développement des Réseaux Neuronaux a pour vocation de rassembler les chercheurs de différentes disciplines des neurosciences (développement\, physiologie\, biochimie\, pharmacologie…) intéressés dans la construction des réseaux de neurones. \nChaque année\, le club Développement des Réseaux Neuronaux organise une journée scientifique dans le but de rassembler ces chercheurs\, pour renforcer leurs interactions et mieux représenter ce domaine de recherche au niveau des neurosciences françaises.
URL:https://www.ijm.fr/event/22nd-annual-meeting-of-the-neural-network-development-club/
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/05/DRN-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260603T171500
DTEND;TZID=Europe/Paris:20260603T190000
DTSTAMP:20260523T152151
CREATED:20260522T151339Z
LAST-MODIFIED:20260522T151339Z
UID:33275-1780506900-1780513200@www.ijm.fr
SUMMARY:Congrès des apprentis chercheurs
DESCRIPTION:L’Institut Jacques Monod\, l’Unité de Biologie Fonctionnelle et Adaptative (Université Paris Cité | CNRS ) et l’association L’Arbre des Connaissances ont le plaisir de vous inviter au Congrès des Apprentis Chercheurs 2026 qui se tiendra le Mercredi 3 Juin 2026 ! \nA cette occasion\, les collégiens et lycéens présenteront le projet scientifique sur lequel ils ont travaillé toute l’année en étant accompagnés par les scientifiques des laboratoires.
URL:https://www.ijm.fr/event/congres-des-apprentis-chercheurs/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/05/web-image-bandeau-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260604T143000
DTEND;TZID=Europe/Paris:20260604T151500
DTSTAMP:20260523T152151
CREATED:20260512T131508Z
LAST-MODIFIED:20260512T131508Z
UID:33088-1780583400-1780586100@www.ijm.fr
SUMMARY:Séminaire de l'Institut Jacques Monod - Prof. Chwee Teck Lim
DESCRIPTION:Invité par l’équipe Ladoux/Mège\, Prof. Chwee Teck Lim ( Mechanobiology Institute\, National University of Singapore ) présentera un séminaire de l’Institut Jacques Monod sur le thème : \nHow Geometry Drives Collective Cell Migration \nRésumé : Cells that migrate as sheets or large cohorts exhibit behaviors that differ markedly from those of individually migrating cells\, particularly when subjected to geometric constraints\, physical confinement\, or out-of-plane topography. Collective cell migration underlies many essential biological processes\, including wound healing\, maintenance of the intestinal epithelium\, embryonic development\, and cancer invasion and metastasis. Understanding these collective behaviors therefore offers valuable insights into tissue repair mechanisms and the design of regenerative medicine strategies. Here\, we investigate the kinematic properties of collectively migrating cell cohorts under a range of well-defined geometric and physical constraints\, including migration along narrow strips and across out-of-plane curved surfaces\, to elucidate how confinement and surface geometry shape collective cell dynamics. \nBio : Professor Lim is the NUS Society Chair Professor and Director of the Institute for Health Innovation and Technology at NUS. He is also the Founding Director of the Singapore Health Technologies Consortium. \nHis research interests include human disease mechanobiology and the development of microfluidic and wearable technologies for healthcare applications. He is a prolific researcher having co-authored over 500 journal publications and delivered more than 550 plenary/keynote/invited lectures. He is also a serial entrepreneur having started six companies with one public listed in 2018. \nProfessor Lim is an Elected Fellow of the Royal Society (UK)\, Royal Academy of Engineering (UK)\, National Academy of Inventors (US)\, IUPESM\,  AIMBE\, IAMBE\, ASEAN Academy of Engineering and Technology\, Academy of Engineering\, Singapore\, Singapore National Academy of Science and the Institution of Engineers. He and his team have garnered over 100 research awards and honours including the President’s Science Award\,  Otto Schmitt Award\, Nature Lifetime Achievement Award for Mentoring in Science\, Asia’s Most Influential Scientist\, Highly Cited Researcher\, IES Prestigious Engineering Achievement Award\, ASEAN Outstanding Engineering Achievement Award\, Asian Scientists 100\, Credit Suisse Technopreneur of the Year Award\, Wall Street Journal Asian Innovation Award (Gold)\, President’s Technology Award\, and the Distinguished Alumni Award among others.
URL:https://www.ijm.fr/event/seminaire-de-linstitut-jacques-monod-prof-chwee-teck-lim/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/05/Bandeau-web-seminar-Lim-Chwee-Teck-scaled.jpg
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DTSTART;TZID=Europe/Paris:20260605T114500
DTEND;TZID=Europe/Paris:20260605T130000
DTSTAMP:20260523T152151
CREATED:20260513T125527Z
LAST-MODIFIED:20260513T125527Z
UID:33097-1780659900-1780664400@www.ijm.fr
SUMMARY:Conférence de l'Institut Jacques Monod - Alexander Meissner
DESCRIPTION:Invité par l’Institut Jacques Monod et l’Unité Epigénétique et Destins Cellulaire\, Alexander Meissner (Directeur\, Max Planck Institute for Molecular Genetics) présentera une conférence de l’Institut Jacques Monod sur le thème : \nEpigenetic regulation in development and disease \nRésumé : \nIn vertebrates\, somatic cells stably maintain globally high DNA methylation levels and protect CpG island promoters\, features that are extensively altered within mammalian extraembryonic tissues and the majority of human cancers. I will present recent insights from various models to explore the non-canonical regulation of DNA methylation \nPublications \nMing-Kang Lee\, Sebastian D. Mackowiak\, Daniel Felismino\, Jeron Venhuizen\, Maria Walther\, Alexander Meissner. Temporal degradation of PRC2 uncovers specific developmental dependencies. bioRxiv 2026.04.18.719361 \nTaguchi A\, Magalhães AP\, Bolondi A\, Lee MK\, Kretzmer H\, Wittler L\, Hnisz D\, Meissner A. Single-cell activation screen identifies hepatic maturation regulators with zonal resolution. Dev Cell. 2026 Mar 11;61(3):553-570.e9. \nHetzel S\, Hodis E\, Torlai Triglia E\, Kovacsovics A\, Steinmann K\, Gnirke A\, Cui M\, McQuaid D\, Weigert R\, Pohl G\, Muzumdar MD\, Leyvraz S\, Keilholz U\, Yaspo ML\, Regev A\, Kretzmer H\, Smith ZD\, Meissner A. Direct genetic transformation bypasses tumor-associated DNA methylation alterations. Genome Biol. 2025 Jul 17;26(1):212. \nGuckelberger P\, Haut L\, Tornisiello R\, Kretzmer H\, Meissner A. HELLS is required for maintaining proper DNA modification at human satellite repeats. Genome Biol. 2025 Jul 17;26(1):211. \nBatki J\, Hetzel S\, Schifferl D\, Bolondi A\, Walther M\, Wittler L\, Grosswendt S\, Herrmann BG\, Meissner A. Extraembryonic gut endoderm cells undergo programmed cell death during development. Nat Cell Biol. 2024 Jun;26(6):868-877. \nSampath Kumar A\, Tian L\, Bolondi A\, Hernández AA\, Stickels R\, Kretzmer H\, Murray E\, Wittler L\, Walther M\, Barakat G\, Haut L\, Elkabetz Y\, Macosko EZ\, Guignard L\, Chen F\, Meissner A. Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nat Genet. 2023 Jul;55(7):1176-1185. \nWeigert R\, Hetzel S\, Bailly N\, Haggerty C\, Ilik IA\, Yung PYK\, Navarro C\, Bolondi A\, Kumar AS\, Anania C\, Brändl B\, Meierhofer D\, Lupiáñez DG\, Müller FJ\, Aktas T\, Elsässer SJ\, Kretzmer H\, Smith ZD\, Meissner A. Dynamic antagonism between key repressive pathways maintains the placental epigenome. Nat Cell Biol. 2023 Apr;25(4):579-591. \nHetzel S\, Mattei AL\, Kretzmer H\, Qu C\, Chen X\, Fan Y\, Wu G\, Roberts KG\, Luger S\, Litzow M\, Rowe J\, Paietta E\, Stock W\, Mardis ER\, Wilson RK\, Downing JR\, Mullighan CG\, Meissner A. Acute lymphoblastic leukemia displays a distinct highly methylated genome. Nat Cancer. 2022 Jun;3(6):768-782. doi: 10.1038/s43018-022-00370-5.
URL:https://www.ijm.fr/event/conference-de-linstitut-jacques-monod-alexander-meissner/
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/05/bandeau-IJM-Lectures-Alexander-Meissner-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260612T140000
DTEND;TZID=Europe/Paris:20260612T170000
DTSTAMP:20260523T152151
CREATED:20260522T145207Z
LAST-MODIFIED:20260522T145207Z
UID:33260-1781272800-1781283600@www.ijm.fr
SUMMARY:Soutenance HDR - Hugo Wioland
DESCRIPTION:Hugo Wioland (équipe Romet-Lemonne/Jégou) va défendre son Habilitation à Diriger des recherche : \nActin biochemical and mechanical diversity \nLe jury sera composé de : \n\nNicolas Joly\, Président\nLaurent Blanchoin\, Rapporteur\nPeter Bieling\, Rapporteur\nAurélie Bertin\, Examinatrice\nPatricia Bassereau\, Examinatrice
URL:https://www.ijm.fr/event/soutenance-hdr-hugo-wioland/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/05/HDR-bandeau-Hugo-Wioland-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260626T114500
DTEND;TZID=Europe/Paris:20260626T130000
DTSTAMP:20260523T152151
CREATED:20260522T145834Z
LAST-MODIFIED:20260522T150044Z
UID:33267-1782474300-1782478800@www.ijm.fr
SUMMARY:Séminaire de l'Institut Jacques Monod - Christian Schlieker
DESCRIPTION:Invité par l’équipe Palancade\, Christian Schlieker (Department of Molecular Biophysics and Biochemistry\, Yale University\, USA) présentera un séminaire de l’Institut Jacques Monod sur le thème : \nBiomolecular Condensates at the Nuclear Envelope: From Mechanism to Therapeutic Modulation \nChristian started his scientific training as an undergraduate at the University of Bonn in Germany\, with a research stay at the University of New South Wales in Sydney\, Australia. He then earned his Ph.D. in the laboratory of Dr. Bernd Bukau at the Center for Molecular Biology (ZMBH) of Heidelberg University\, where he used biochemical and biophysical approaches to uncover how Clp/HSP100 AAA+ ATPases counteract proteotoxic stress. \nChristian continued his training as an EMBO postdoctoral fellow with Dr. Hidde Ploegh at Harvard Medical School and the Whitehead Institute/MIT\, where he explored the ubiquitin–proteasome system and discovered a novel role for a ubiquitin-like modifier in RNA biology. \nChristian joined the Department of Molecular Biophysics and Biochemistry at Yale University in 2009\, where he is currently Professor and Director of Undergraduate Studies\, with a secondary appointment in the Department of Cell Biology. He is a recipient of the NIH Director’s New Innovator Award and has served on the scientific advisory board of the Dystonia Medical Research Foundation and reviewed for the NIH\, the Department of Defense\, the German Excellence Initiative\, ANR and the European Research Council\, among others. At Yale\, he has chaired the Committee on Majors for Yale College and currently serves on the Advisory Board of the Yale Center for Molecular Discovery. Starting in July 2026\, he will chair the Department of Molecular Biophysics and Biochemistry. \nBrief synopsis \nWe explore how cells build and safeguard two the nuclear envelope and the endoplasmic reticulum. Our work focuses on how disruptions in membrane organization and phase separation drive the formation of aberrant condensates that are increasingly implicated in neurological disease. To tackle these questions\, we develop and apply new tools that allow us to probe and modulate these processes across scales\, from the dynamics of individual proteins and condensates to genome-wide functional screens. By integrating cell biology\, biochemistry\, and computational approaches with patient-derived and animal model systems\, we aim to uncover fundamental principles of cellular organization and translate these discoveries into novel therapeutic strategies for movement disorders and related conditions. \nWe recently developed a high-content platform and computational pipeline to screen modulators of nuclear condensates across chemical and genetic space. This effort identified novel players in nuclear condensates formation\, along with small molecules that modualte proteotoxic condensates. Application of the platform in a genome-wide CRISPR knockout screen revealed strong enrichment of candidate genes linked to primary microcephaly and related neurodevelopmental disorders\, pointing to condensate dysregulation as a shared molecular axis across disease. \nA complementary line of work asks how the nuclear pore complex itself contributes to protein quality control. Co-translational folding allows nascent proteins to begin folding as they are synthesized\, reducing the risk of aggregation and avoiding energy-intensive unfolding steps. We propose that karyopherins and flexible FG-nucleoporins not only safeguard the nuclear permeability barrier but also generate a supportive environment — a “folding phase” — that promotes correct folding of proteins entering the nucleus. This perspective offers new insight into how disruptions in nuclear transport and protein quality control may contribute to neurological disease. Together\, these efforts may inform biotechnological advances in protein stability and targeted therapeutics for diseases of disrupted folding. \nSelected publications \n\nProphet SM\, Rampello AJ\, Niescier RF\, Gentile JE\, Mallik S\, Koleske AJ\, Schlieker C: Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities. Nat Cell Biol 2022\, 24:1630–1641.\nPoch D\, Mukherjee C\, Mallik S\, Todorow V\, Kuiper EFE\, Dhingra N\, Surovtseva YV\, Schlieker C: Integrative Chemical Genetics Platform Identifies Condensate Modulators Linked to Neurological Disorders. bioRxiv 2025\, doi:10.1101/2025.06.07.658469.\nRampello AJ\, Laudermilch E\, Vishnoi N\, Prophet SM\, Shao L\, Zhao C\, Lusk CP\, Schlieker C: Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2. J Cell Biol 2020\, 219:e201910185.\nMallik S\, Poch D\, Burick S\, Schlieker C: Protein folding and quality control during nuclear transport. Curr Opin Cell Biol 2024\, 90:102407.
URL:https://www.ijm.fr/event/seminaire-de-linstitut-jacques-monod-christian-schlieker/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/05/Bandeau-web-seminar-Christian-Schlieker-scaled.jpg
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