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X-WR-CALNAME:Institut Jacques Monod
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X-WR-CALDESC:Évènements pour Institut Jacques Monod
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DTSTART;TZID=Europe/Paris:20250404T114500
DTEND;TZID=Europe/Paris:20250404T130000
DTSTAMP:20260523T235446
CREATED:20250324T145408Z
LAST-MODIFIED:20250324T145408Z
UID:27686-1743767100-1743771600@www.ijm.fr
SUMMARY:Séminaire de l'Institut Jacques Monod - Lionel Christiaen
DESCRIPTION:Invité par l’équipe Minc\, Lionel Christiaen (Michael Sars Centre\, University of Bergen\, Bergen\, Norway) va présenter un séminaire de l’Institut Jacques Monod sur le thème : \nRegulation of deterministic development \nRésumé : \nChristiaen’s research aims at understanding how tissue-specific regulatory programs and cell-cell communication coordinate cellular behavior in the context of animal development\, regeneration and evolution. His laboratory focuses on mesodermal lineages that produce both heart and head muscles\, using the ascidian Ciona as model. His laboratory has contributed seminal findings in developmental and evolutionary biology\, identifying key processes contributing to human congenital disorders. The Ciona model provides a unique opportunity to study the regulation of chordate development at single cell resolution\, thanks to a highly deterministic (“hard-wired”) mode of embryogenesis. However\, recent attempts to uncover the impact of varying temperatures in a changing world are beginning to reveal regulative mechanisms of thermal adaptation.
URL:https://www.ijm.fr/event/seminaire-de-linstitut-jacques-monod-lionel-christiaen/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Lionel-Christiaen-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250408T114500
DTEND;TZID=Europe/Paris:20250408T130000
DTSTAMP:20260523T235446
CREATED:20250326T143945Z
LAST-MODIFIED:20250326T144052Z
UID:27700-1744112700-1744117200@www.ijm.fr
SUMMARY:Seminaire - Suzette Lust
DESCRIPTION:Invitée par l’Institut Jacques Monod\, Suzette Lust (Postdoctoral researcher in Danijela Matic Vignjevic’s team – Cell migration and invasion Laboratory at Institut Curie) va présenter le séminaire sur le thème : \nUnderstanding the role of interstitial flow in vascular smooth muscle cell phenotype in the context of aortic aneurysms \n  \nCe séminaire se déroule dans le cadre des Paris Postdocs Seminars. \nRésumé : \nAortic aneurysms are abnormal enlargements of blood vessel diameter caused by aberrant extra-cellular matrix (ECM) remodelling. As the tissue dilates\, it loses its mechanical integrity\, exposing patients to risk of highly fatal aortic dissections or ruptures. This is mediated in part by phenotypic switching and or apoptosis of the intima-resident vascular smooth muscles (VSMCs). What drives this pathology is not well understood\, particularly in the case of aneurysms in Bicuspid Aortic Valve disease (BAV) patients\, a congenital condition characterised by the malformation of the aortic valve resulting in only 2 leaflets. Improvements in imaging techniques have now allowed pathological blood flow patterns to be correlated to aneurysm morphology and indeed there is increasing evidence that mechanotransduction from flow may be a driver of aneurysm development. Blood flow imparts mechanical forces to cells through stretching and frictional shear forces and we are focused here on the interstitial flow driven into the wall by differential pressure gradients within the aorta. \nWe hypothesise that interstitial flow plays a crucial role in regulating VSMC phenotype and ECM interactions and that this may be used to correlate disrupted flow patterns seen in BAV patients to the morphology changes in their aortas. \nTo test this hypothesis\, we created a reductionist in-vitro model culturing VSMCs in 3D under interstitial flow. We combined a synthetic PEG based ECM mimicking hydrogel with primary cultures of VSCMs with a microfluidics setup. \nWe showed hydrogels doctored with degradable bioactive peptides could be broken down by exogenous and cell derived MMPs. We measured hydrogel permeability using 2 separate techniques which confirmed the material to have a low permeability compared to other standard hydrogels\, on the order of 10−16 m2. Furthermore\, we characterised mass transport of solutes within hydrogels and were able to demonstrate a negligible impact of changing polymer solid content on diffusivity in hydrogels of up to 5% weight/volume for molecules up to 40 kDa in size. Via production of MMPs\, VSMCs break down the hydrogel and importantly by day 7 of culture\, we detected newly synthesised fibronectin\, collagen 1 and 4 proteins. We stimulated encapsulated cells with interstitial flows demonstrating that cells align to the flow direction. Finally\, we performed RNA sequencing on 3 human patient samples comparing standard culture conditions\, non-flow stimulated encapsulated cells and interstitial-flow stimulated cells. The data set reveals significant upregulation of genes in multiple pathways associated with cyclic AMP production\, which plays a crucial role in regulating VSMC contractility and calcium signalling and hence phenotype. The data suggests that this is mediated via activation of G-protein receptors leading to increased expression of adenylyl cyclase but this remains to be confirmed. \nIn conclusion\, we developed a novel in-vitro platform to study the impact of interstitial flow on VSMC behaviour. Our data suggests that interstitial flow may play a regulating role in determining VSMC phenotype with potential consequences for matrix remodelling in disease.
URL:https://www.ijm.fr/event/seminaire-suzette-lust/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250408-Suzette-Lust-web-scaled.jpg
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20250409
DTEND;VALUE=DATE:20250412
DTSTAMP:20260523T235446
CREATED:20241209T104027Z
LAST-MODIFIED:20241209T125452Z
UID:26068-1744156800-1744415999@www.ijm.fr
SUMMARY:Paris - Munich Epigenetics Workshop & Symposium 2025
DESCRIPTION:La deuxième édition du colloque Paris-Munich épigénétique se tiendra du 9 au 11 avril 2025 à l’amphithéâtre Buffon. La participation est gratuite mais l’inscription est obligatoire. \nRendez-vous sur le site pour connaître le programme et vous inscrire. \nLe Paris-Munich Epigenetics Worshop & Symposium est composé de deux parties : \n\nle SYMPOSIUM\, ouvert à tous les étudiants et chercheurs des communautés de Paris/Munich et au-delà\nun WORKSHOP pour les chercheurs doctorants ou postdoctorants sélectionnés qui sont nouveaux dans le domaine de l’épigénétique.\n\nLe WORKSHOP aura lieu le 9 avril avant le symposium\, et est ouvert aux chercheurs doctorants et postdoctorants sélectionnés qui découvrent le domaine de l’épigénétique. L’atelier se concentre sur les concepts fondamentaux de la recherche de pointe en épigénétique\, enseignés par des experts universitaires chevronnés\, ainsi que sur l’orientation professionnelle et les compétences en matière de communication\, présentées par d’anciens étudiants et des professionnels du domaine. Les participants à l’atelier auront l’occasion de nouer des contacts et d’échanger\, grâce aux discussions qui auront lieu pendant l’atelier\, ainsi qu’aux exposés succincts et aux affiches qui seront présentés pendant le symposium. \nLe SYMPOSIUM aura lieu du 9 au 11 avril 2025 et est ouvert à tous les étudiants et scientifiques intéressés des communautés de Paris et de Munich et d’ailleurs. Au cours du symposium\, des orateurs renommés des deux communautés présenteront leurs dernières découvertes en matière d’épigénétique lors de sessions sur l’environnement\, l’organisation\, le remodelage et la reprogrammation de la chromatine. Des présentations courtes et des posters de chercheurs en début de carrière (doctorants et post-doctorants) seront sélectionnés parmi les résumés soumis. \nLa date limite de soumission des résumés et des demandes d’inscription aux ateliers est fixée au 15 janvier 2025.
URL:https://www.ijm.fr/event/paris-munich-epigenetics-workshop-symposium-2025/
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/bandeau-scaled.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250409T093000
DTEND;TZID=Europe/Paris:20250409T110000
DTSTAMP:20260523T235446
CREATED:20250331T094740Z
LAST-MODIFIED:20250331T094740Z
UID:27733-1744191000-1744196400@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:La prochaine réunion du Cytoskeleton club aura lieu mercredi 9 avril à l’Institut Pasteur : \n\nIngrid Billault-Chaumartin (post-doc\,  Romet-Lemonne/Jegou team\, IJM) présentera « How similar is actin assembly between distant species ? »\nNicolas Joly ( Researcher \,  Pintard tema\, IJM)  présentera « Mechanistic Insights into Katanin Activation: Coupling Microtubule Binding with ATP Hydrolysis
URL:https://www.ijm.fr/event/cytoskeleton-club-6/
LOCATION:Institut Pasteur\, 28 rue du dr roux\, 75015 Paris\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/20250319bandeau-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250411T114500
DTEND;TZID=Europe/Paris:20250411T130000
DTSTAMP:20260523T235446
CREATED:20250313T131823Z
LAST-MODIFIED:20250313T131823Z
UID:27622-1744371900-1744376400@www.ijm.fr
SUMMARY:Séminaire de l'Institut Jacques Monod - Marion Silies
DESCRIPTION:Invitée par l’équipe Konstantinides\, Dr. Marion Silies (Johannes-Gutenberg-University Mainz\, Germany) présentera un séminaire de l’Institut Jacques Monod sur le thème : \nHeterogeneity of connectivity and function in the fly visual system \nRésumé : \nVisual systems are considered homogeneous structures where repeating visual units contain the same circuit motifs that fulfil the same functional role\, leading to translation invariance. However\, our recent work\, analyzing full fly brain connectomes\, revealed remarkable heterogeneity\, even within anatomically and genetically identifiable cell types. I will describe this heterogeneity in synaptic connectivity\, and address where it arises developmentally. Furthermore\, I will discuss how heterogeneous circuit motifs can lead to degeneracy of neuronal function\, and thus to both\, reliablility and flexiblity of neuronal information processing in the visual system.
URL:https://www.ijm.fr/event/seminaire-de-linstitut-jacques-monod-marion-silies/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/03/Bandeau-web-seminar-Marion-Silies-scaled.jpg
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