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DTSTART;TZID=Europe/Paris:20250205T183000
DTEND;TZID=Europe/Paris:20250205T200000
DTSTAMP:20260524T011351
CREATED:20250131T114321Z
LAST-MODIFIED:20250131T114444Z
UID:26995-1738780200-1738785600@www.ijm.fr
SUMMARY:Conférence grand public - Nouveaux apports de l’archéogénétique dans l’étude du Néolithique en France
DESCRIPTION:Mercredi 5 février\, Eva-Maria Geigl (directrice de recherche au CNRS\, Université Paris Cité\, CNRS\, UMR 7592\, Institut Jacques Monod) présentera la conférence grand-public  » Nouveaux apports de l’archéogénétique dans l’étude du Néolithique en France«  au Musée d’Archéologie Nationale  du château de Saint Germain-en-Laye.  \nCette conférence est gratuite sur réservation : lien de réservation \n  \nRésumé : \nEn Europe il y a 8500 – 6000 ans\, le mode de vie d’agriculteurs a été introduit et a supplanté le mode de vie de chasseurs-cueilleurs mésolithiques. \nL’analyse des génomes d’individus ayant vécu à cette époque a montré que cette transition culturelle a été la conséquence d’une migration des descendants des premiers agriculteurs du Proche-Orient qui sont partis d’Anatolie vers 6500 avant l’ère commune (AEC commençant à l’an zéro) pour arriver dans le Bassin parisien vers 5100 AEC. Durant les millénaires suivants\, de nouvelles cultures émergent. Notre analyse génomique d’individus associés à différentes cultures néolithiques nous a permis d’identifier migrations\, métissages avec les chasseurs-cueilleurs mésolithiques et certains aspects du fonctionnement de ces sociétés néolithiques. \nA la fin du 4ème et au début du 3ème millénaire AEC\, des populations originaires des steppes pontiques-caspiennes ont migré vers l’ouest. Leur signature génomique caractéristique est alors trouvé dans les génomes d’individus en Europe centrale et septentrionale associées à la culture de la céramique cordée. Nous avons caractérisé\, au travers d’une analyse archéogénétique des individus de la fin du Néolithique dans le Bassin parisien\, des dynamiques de métissage non détectées auparavant qui coïncident avec les transitions culturelles de la céramique cordée et du campaniforme. \nConférence par Eva-Maria Geigl\, directrice de recherche au CNRS\, Université Paris Cité\, CNRS\, UMR 7592\, Institut Jacques Monod
URL:https://www.ijm.fr/event/conference-grand-public-nouveaux-apports-de-larcheogenetique-dans-letude-du-neolithique-en-france/
LOCATION:Musée d’Archéologie Nationale – Domaine National du château de Saint-Germain-en-Laye\, Musée d’Archéologie Nationale Domaine National du château de Saint-Germain-en-Laye Château – Place Charles de Gaulle\, 78 105 Saint-Germain-en-Laye cedex\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/image-bandeau-WP-4-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250206T190000
DTEND;TZID=Europe/Paris:20250206T213000
DTSTAMP:20260524T011351
CREATED:20250115T091647Z
LAST-MODIFIED:20250115T124635Z
UID:26591-1738868400-1738877400@www.ijm.fr
SUMMARY:Conférence dansée : Move your science
DESCRIPTION:Conférence dansée : MOVE YOUR SCIENCE\n  \nJeudi 6 février à 19h | Hall Buffon\, Institut Jacques Monod\nGratuit sur inscription\n  \nCréation collective avec les doctorant.es Kenza Alaoui Sossé\, Amandine Albizzati\, Mariam Bougma\, Stéphanie Brunot\, Mert Can\, Johanna Exenberger\, Audrey Gosset\, Capucine Gros\, Emile Le Lièvre et Joséphine Schelle   \nChorégraphie et recherche danse/sciences : Cosetta Graffione et Namiko Gahier-Ogawa \nCoordination scientifique et recherche danse/sciences : Mélina Heuzé\, enseignante-chercheuse \n Depuis septembre\, dix doctorant·es de l’Université Paris Cité toutes disciplines confondues\, travaillent avec les chorégraphes Cosetta Graffione et Namiko Gahier-Ogawa ainsi que l’enseignante-chercheuse Mélina Heuzé pour partager leur projet scientifique dans un esprit de médiation vers le grand public.\nDans un dialogue art et sciences\, le public pourra éprouver les principes scientifiques de leur travail de thèse à travers des séquences dansées faisant émerger une poésie des corps. \nCette conférence dansée en quatre tableaux sera suivie d’un échange avec le public autour d’un verre de l’amitié.
URL:https://www.ijm.fr/event/conference-dansee-move-your-science/
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/heuze-1-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250207T114500
DTEND;TZID=Europe/Paris:20250207T130000
DTSTAMP:20260524T011351
CREATED:20241219T104206Z
LAST-MODIFIED:20241219T104601Z
UID:26246-1738928700-1738933200@www.ijm.fr
SUMMARY:Conférence de l'Institut Jacques Monod - Sophie G. Martin
DESCRIPTION:Le vendredi 7 février 2025\, Sophie G. Martin (Department of Molecular and Cellular Biology\, University of Geneva\, Switzerland) présentera une Conférence de l’Institut Jacques Monod sur le thème : \nSignaling and actin focus architecture for cell-cell fusion \n  \nRésumé : \nSexual reproduction is ubiquitous amongst eukaryotes. This requires alternation of cell-cell (gamete) fusion and genome reduction through meiosis. My lab has been using the yeast sexual reproduction pathway to study how cells polarize to find a mate and mount a fusion reaction. In the fission yeast Schizosaccharomyces pombe\, sexual reproduction occurs between P and M cells\, which communicate through pheromone-GPCR-MAPK signaling\, driving the formation of cell pairs. Transition from gametes to zygote involves local cell wall digestion at the point of gamete contact\, while preserving cell integrity. We have shown that cell-cell fusion requires the actin fusion focus\, an aster-like assembly of linear actin filaments assembled by the formin Fus1\, which concentrates both signaling molecules and secretory vesicles carrying cell wall digestion enyzmes. I will present our recent work on the molecular mechanisms of formation of the actin fusion focus\, which require both formation of a formin biomolecular condensate and cytoskeletal focusing through formin-myosin feedback. I will also describe our progress in understanding the roles of local MAPK and PAK signaling for cells to pierce their cell wall once and only once.
URL:https://www.ijm.fr/event/institut-jacques-monod-lectures-sophie-g-martin/
LOCATION:Institut Jacques Monod Amphithéâtre Buffon\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Sophie-Martin-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250211T114500
DTEND;TZID=Europe/Paris:20250211T130000
DTSTAMP:20260524T011351
CREATED:20241223T131853Z
LAST-MODIFIED:20241223T131853Z
UID:26284-1739274300-1739278800@www.ijm.fr
SUMMARY:Conférence de l'Institut Jacques Monod - Richard Benton
DESCRIPTION:Le mardi 11 février\, Richard Benton (Center for Integrative Genomics\, University of Lausanne) présentera une Conférence de l’Institut Jacques Monod sur le thème : \nFatal chemosensation\, and how insects fight back \n  \nRésumé : \nInsecticide resistance is a widespread challenge for the management of vectors transmitting pathogens and agricultural pests\, requiring a better understanding of the genetic mechanisms underlying the evolution of resistance. Drosophila sechellia is a compelling model for such studies as it naturally evolved resistance to octanoic acid\, an abundant chemical of its noni fruit host that is toxic for other insects\, including close relatives D. simulans and D. melanogaster. We have used a multi-pronged strategy to identify genes contributing to octanoic acid resistance. We began by experimentally-evolving D. simulans strains with higher tolerance to octanoic acid and determined the resulting genetic architecture. To identify specific candidate genes\, we integrated this analysis with a genome-wide association study of octanoic acid resistance in D. simulans and a genome-wide CRISPR selection screen upon octanoic acid exposure in D. melanogaster S2R+ cultured cells. We identified four candidates\, with diverse predicted molecular and expression properties\, and validated their relevance using genetic analyses in D. melanogaster. Two of these genes displayed an increased expression in the experimentally-evolved strains\, paralleling their higher levels of expression in D. sechellia. Our results suggest an adaptive role of these genes in shaping toxin resistance both under laboratory conditions and during D. sechellia’s evolutionary history.
URL:https://www.ijm.fr/event/conference-de-linstitut-jacques-monod-richard-benton/
LOCATION:Bâtiment Condorcet Amphithéâtre Pierre Gilles de Gennes\, 4 rue Elsa Morante\, Paris\, Sélectionner un État :\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/WP-IJM-Lectures-Richard-Benton-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250212T140000
DTEND;TZID=Europe/Paris:20250212T150000
DTSTAMP:20260524T011351
CREATED:20250127T140538Z
LAST-MODIFIED:20250129T101813Z
UID:26829-1739368800-1739372400@www.ijm.fr
SUMMARY:Séminaire - Felix Ruhnow
DESCRIPTION:Invité par le Centre for Genomic Regulation\, Felix Ruhnow va présenter un séminaire sur le thème : \nNuMA is a mitotic adaptor protein that activates dynein and connects it to microtubule minus ends \n  \nRésumé : \nNuclear mitotic apparatus protein (NuMA) is indispensable for the mitotic functions of the major microtubule minus-end directed motor cytoplasmic dynein 1. NuMA and dynein are both essential for correct spindle pole organization. How these proteins cooperate to gather microtubule minus ends at spindle poles remains unclear. Here we use microscopy-based in vitro reconstitutions to demonstrate that NuMA is a dynein adaptor\, activating processive dynein motility together with dynein’s cofactors dynactin and Lissencephaly-1 (Lis1). Additionally\, we find that NuMA binds and stabilizes microtubule minus ends\, allowing dynein/dynactin/NuMA. to transport microtubule minus ends as cargo to other minus ends. We further show that the microtubule-nucleating γ-tubulin ring complex (γTuRC) hinders NuMA binding and that NuMA can only cap minus ends of γTuRC-nucleated microtubules after γTuRC release. These results provide new mechanistic insight into how dynein\, dynactin\, NuMA\, Lis1 together with γTuRC and uncapping proteins cooperate to organize spindle poles in cells.
URL:https://www.ijm.fr/event/seminaire-felix-ruhnow/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-2-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250214T114500
DTEND;TZID=Europe/Paris:20250214T130000
DTSTAMP:20260524T011351
CREATED:20241217T133040Z
LAST-MODIFIED:20241217T133040Z
UID:26232-1739533500-1739538000@www.ijm.fr
SUMMARY:Séminaire de l'Institut Jacques Monod - Peter Andolfatto
DESCRIPTION:Invité par l’équipe Courtier\, Peter Andolfatto (Professor\, Dept. of Biological Sciences\, Columbia University) présentera un séminaire de l’Institut Jacques Monod sur le thème : \nThe evolution of toxin-resistant Na+\,K+-ATPases: new insights from frogs and fireflies  \n  \nWe study the process of adaptive evolution through the lens of repeated adaptation of many distantly species to a similar selection pressure (i.e. « parallel evolution »). Over the past decade\, we have explored patterns of adaptation in the context of animals that have specialized in eating plants\, or other animals\, that contain toxic cardiotonic steroids (CTS). CTS are toxic to animals because they inhibit sodium-potassium ATPase\, a key enzyme in animals needed in everything from maintaining cell homeostasis\, muscle contraction to neuron activity. Here I review our most recent work combining comparative molecular evolution\, molecular and biochemical assays and in vivo engineering of Drosophila to deduce the rules governing the adaptive evolution of CTS resistance in animals. Together\, our results have interesting implications for how epistasis and pleiotropy both limit the rate of adaptive protein evolution and increase its predictability.
URL:https://www.ijm.fr/event/seminaire-de-linstitut-jacques-monod-peter-andolfatto/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2024/12/Bandeau-web-seminar-Peter-Andolfatto-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250219T093000
DTEND;TZID=Europe/Paris:20250219T110000
DTSTAMP:20260524T011351
CREATED:20250205T110041Z
LAST-MODIFIED:20250205T110041Z
UID:27109-1739957400-1739962800@www.ijm.fr
SUMMARY:Cytoskeleton club
DESCRIPTION:La prochaine réunion du Cytoskeleton club aura lieu le mercredi 19 février : \n\nRayane Dibsy (post-doc\, A. Echard’s Lab\, Institut Pasteur présentera  «  The proteasome promotes cytokinetic abscission by relieving Aurora B kinase-mediated inhibition of ESCRT-III turnover. »\nJonathan Fouchard ( Researcher\, Laboratoire de Biologie du Développement\, IBPS) présentera ‘Three-dimensional cell shape\, focal adhesions and vimentin during spreading’
URL:https://www.ijm.fr/event/cytoskeleton-club-4/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/02/20250219bandeau-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250224T114500
DTEND;TZID=Europe/Paris:20250224T130000
DTSTAMP:20260524T011351
CREATED:20250128T140351Z
LAST-MODIFIED:20250214T094546Z
UID:26854-1740397500-1740402000@www.ijm.fr
SUMMARY:[Annulé] Séminaire de l'Institut Jacques Monod - Marla Sokolowski
DESCRIPTION:Ce séminaire est annulé.\n  \nInvité par l’équipe Courtier\, Marla Sokolowski (Department of Ecology and Evolutionary Biology\, University of Toronto) va présenter un séminaire de l’Institut Jacques Monod sur le thème : \nThe foraging gene: will that be for here or to go? \nRésumé : \nThe Drosophila melanogaster foraging (for) gene\, with its rover and sitter larval foraging variants\, is an established behaviour genetics model. Orthologues of the foraging gene also modulate the individual and social behaviour of a wide range of species including the regulation of behaviour in eusocial insects. In Drosophila\, foraging modifies the expression of multiple traits\, including feeding and foraging\, stress tolerance\, sleep\, metabolism\, dispersal\, escape responses\, social behaviour\, and learning and memory. From a social context perspective\, Drosophila foraging affects larval clustering during foraging under high larval densities\, adult social behaviour and social networks\, and social learning. We wondered how foraging accomplishes its behavioural pleiotropy at the molecular level. We found that D. melanogaster foraging has a complex modular genomic structure with four promoters\, 21 transcripts\, and eight protein isoforms. The four promoter modules are differentially regulated during development and in a timescale\, tissue\, and cell-type dependent manner. Two examples illustrate these findings: the epigenetic regulation of the adult rover-sitter foraging-related phenotypes by G9a\, a histone methyltransferase\, and the regulation of differences in the latency of rover compared to sitter larval escape responses to noxious stimuli such as parasitoid wasps. Our work provides a nuanced picture of the molecular basis of foraging’s pleiotropy.
URL:https://www.ijm.fr/event/seminaire-de-linstitut-jacques-monod-marla-sokolowski/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/Bandeau-web-seminar-Marla-Sokolowski-scaled.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250225T114500
DTEND;TZID=Europe/Paris:20250225T130000
DTSTAMP:20260524T011351
CREATED:20250123T141141Z
LAST-MODIFIED:20250123T141141Z
UID:26788-1740483900-1740488400@www.ijm.fr
SUMMARY:Paris Postdoc Seminar - Nathaniel Henneman
DESCRIPTION:Invité par l’Institut Jacques Monod\, Nathaniel Henneman (team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM)) va présenter un Paris Postdoc Seminar sur le thème : \nNuclear functions of nutrient sensing signaling for metabolic adaptation \n  \nPrésentation et résumé : \nI am a Postdoc in the team of Ganna Panasyuk at Institut Necker Enfants Malades (INEM). I graduated from Bates College (USA) in 2016\, majoring in Biology. I then spent two years working on retinal degeneration at Emory University before obtaining my master’s degree at University of Paris Descartes in 2019 and defended my PhD in December 2023. \nOne of the key questions I am to address in my work is how cellular metabolism\, gene expression and transcription\, are all coordinated. Energy stress in fasting is managed by activating autophagy and promoting the transcriptional remodeling of metabolism. Cytosolic nutrient sensors coordinate extracellular nutrient availability with intracellular metabolic processes to allow for cell survival. Class 3 PI3K is a highly conserved nutrient sensor known to regulate autophagy and endocytosis in response to varying nutrient conditions. It’s direct role in transcription\, however\, was only suggested in few studies in yeast and plants. However\, we believe there is a nuclear pool of class 3 PI3K that directly regulates gene expression for metabolic adaptation. My work aims to address this unmet burden in the field. We find that nuclear class 3 PI3K regulates the transcriptional response to nutrient stress by controlling RNA Polymerase II\, the Set1/COMPASS methyltransferase\, and nuclear methionine to SAM flux. I aim to understand how these players are needed for our fasting adaptation and how these mechanisms could affect our metabolic resilience.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-nathaniel-henneman/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2025/01/20250225-Nathaniel-Hennman-web-scaled.jpg
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