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DTSTART;TZID=Europe/Paris:20260407T114500
DTEND;TZID=Europe/Paris:20260407T130000
DTSTAMP:20260407T120313
CREATED:20260324T132642Z
LAST-MODIFIED:20260324T132642Z
UID:32555-1775562300-1775566800@www.ijm.fr
SUMMARY:Paris Postdoc seminar - Annapaola Angrisani
DESCRIPTION:Annapaola Angrisani (Institut Curie) présentera un Paris Postdoc Seminar sur le thème : \nUnderstanding Centromere Fragility : Replication Stress and DNA Damage Burden \nRésumé : \nThe centromere is a key chromosomal region required for accurate chromosome segregation. Despite its essential role\, the centromere is inherently fragile\, exhibiting a high susceptibility to replication stress and DNA damage that contributes to chromosome breakage and aneuploidy. This fragility stems from the repetitive DNA architecture of centromeric sequences and their unique chromatin environment\, which distinguish centromere replication dynamics from the rest of the genome. \nIn the seminar\, I will examine how replication stress—common in precancerous and cancer contexts—promotes centromere instability. \nMechanistically\, we show that the centromeric replisome operates under finely tuned and unique replication programs supported by specialized DNA replication and repair factors. \nI will also discuss the specific DNA lesions to which centromeres are particularly prone\, and how these lesions can potentially trigger centromere breakages and recombination events\, threating genomic integrity.
URL:https://www.ijm.fr/event/paris-postdoc-seminar-annapaola-angrisani/
LOCATION:Institut Jacques Monod Salle François Jacob\, 15 rue Hélène Brion\, Paris\, 75013\, France
ATTACH;FMTTYPE=image/jpeg:https://www.ijm.fr/wp-content/uploads/2026/03/20260407-Annapaola-Angrisani-web-scaled.jpg
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