Transcriptional networks and neural differentiation



Our research projects are devoted to the molecular mechanisms that regulate cell state during the formation of embryonic spinal cord and rhabdomyosarcoma tumours. To do so, we focus on the state dynamics generated by transcription factors of the PAX family and we use stem cell-derived organoids as study models


Group Leader: Vanessa Ribes

Inserm Researcher

+33 (0)157278193







Research Topics:

Biologie quantitative et modélisation , Développement et évolutionDynamique du génome et des chromosomes, Pathologies moléculaires et cellulaires


Selected publications:


Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification.

Mouilleau V, Vaslin C, Robert R, Gribaudo S, Nicolas N, Jarrige M, Terray A, Lesueur L, Mathis MW, Croft G, Daynac M, Rouiller-Fabre V, Wichterle H, Ribes V, Martinat C, Nedelec S. Development. 2021 Mar 29;148(6):dev194514. doi: 10.1242/dev.194514.


The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition.

Gonzalez Curto G, Der Vartanian A, Frarma YE, Manceau L, Baldi L, Prisco S, Elarouci N, Causeret F, Korenkov D, Rigolet M, Aurade F, De Reynies A, Contremoulins V, Relaix F, Faklaris O, Briscoe J, Gilardi-Hebenstreit P, Ribes V. PLoS Genet. 2020 Nov 11;16(11):e1009164. doi: 10.1371/journal.pgen.1009164.


Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation.

Darrigrand JF, Valente M, Comai G, Martinez P, Petit M, Nishinakamura R, Osorio DS, Renault G, Marchiol C, Ribes V, Cadot B. Elife. 2020 Feb 27;9:e50325. doi: 10.7554/eLife.50325.


BMP4 patterns Smad activity and generates stereotyped cell fate organization in spinal organoids.

Duval N, Vaslin C, Barata TC, Frarma Y, Contremoulins V, Baudin X, Nedelec S, Ribes VC. Development. 2019 Jul 25;146(14):dev175430. doi: 10.1242/dev.175430.


Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons.

Gard C, Gonzalez Curto G, Frarma YE, Chollet E, Duval N, Auzié V, Auradé F, Vigier L, Relaix F, Pierani A, Causeret F, Ribes V. Dev Biol. 2017 Dec 1;432(1):24-33. doi: 10.1016/j.ydbio.2017.06.014.


Structures and properties of PAX linked regulatory networks architecting and pacing the emergence of neuronal diversity.

Curto GG, Gard C, Ribes V. Semin Cell Dev Biol. 2015 Aug;44:75-86. doi: 10.1016/j.semcdb.2015.09.010.


Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube.

Moore S, Ribes V, Terriente J, Wilkinson D, Relaix F, Briscoe J. PLoS Genet. 2013;9(10):e1003811. doi: 10.1371/journal.pgen.1003811.


Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube.

Balaskas N, Ribeiro A, Panovska J, Dessaud E, Sasai N, Page KM, Briscoe J, Ribes V. Cell. 2012 Jan 20;148(1-2):273-84. doi: 10.1016/j.cell.2011.10.047.