Développement, signalisation et trafic



Brigui A, Hofmann L, Argüelles C, Sanial M, Holmgren R and Plessis A.
Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases. Open Biol. 2015 Oct;5(10).

Kim, E. Y. Hsia, C. Brigui, A. Plessis A., Beachy P. A and Zheng X. The role of ciliary trafficking in Hedgehog receptor signaling. Sc. Signal.; (2015) Jun 2;8(379):ra55


Yanai H., Yoshioka Y., Yoshida H., Nakao Y., Plessis A. and Yamaguchi M.. Drosophila myeloid leukemia factor cooperates with DREF to activate the JNK signaling pathway. Oncogenesis (2014) 3:e98


Brunet T., Bouclet A., Ahmadi P., Mitrossilis D., Driquez B., Brunet A-C., Henry L., Serman F., Béalle G., Ménager C., Dumas-Bouchiat F., Givord D., Yanicostas C., Le-Roy D.,  M. Dempsey N., Plessis A. and Farge E.. Bilateria early mesoderm specification is determined by beta-catenin dependent mechanical induction. Nature Comm. (2013) 4:2821. Commentaires: Nature 504 (2013), “News and views” et


Bras S, Martin-Lannerée S, Gobert V, Augé B, Breig O, Sanial M, Yamaguchi M, Haenlin M, Plessis A*, Waltzer L.* (* co-corresp. authors). Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis. Proc Natl Acad Sci U S A. 2012 109:4986-91
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S. Netter, C. Marchal, G. Vinatier, M. Sanial, A. Plessis, A.-M. Pret, L. Théodore and B. Limbourg-Bouchon; The HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling. PLOS One2012 7: e34310.
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Farzan S. F., Ascano, A., Ogden S. K, Sanial M., Brigui A., Plessis A. and Robbins D. J. Costal2 Functions as a Microtubule-Dependent Motor in the Hedgehog Signal Transduction Pathway. Current Biology 2008: 18,1-6.


Claret S., Sanial M.,and Plessis A. Evidence for a novel positive feedback loop in the Hedgehog pathway: the seven transmembrane-domains protein Smoothened and the kinase Fused act on each other. Current Biology 2007: 17, 1326-1333.


Malpel S., Claret S., Sanial M., Brigui A., Piolot T., Daviet L., Martin-Lannerée S. and  Plessis A. The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway. Developmental Biology 2006:  303, 121-133.

Dussillol F, Brissard-Zahraoui J. , Limbourg-Bouchon B., Boucher D., Fouix S., Lamour-Isnard C.,  Plessis A. and Busson D. Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs. Developmental biology 291 (1): 53-66.

Martin-Lannerée S., Lasbleiz C., Sanial M., Fouix S., Besse F. and Plessis A.  Characterization of the Drosophila Myeloid Leukemia Factor. Genes to Cells 2006: 1317-35.


Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V, Maire S, Brun C, Jacq B, Arpin M, Bellaiche Y, Bellusci S, Benaroch P, Bornens M, Chanet R, Chavrier P, Delattre O, Doye V, Fehon R, Faye G, Galli T, Girault JA, Goud B, de Gunzburg J, Johannes L, Junier MP, Mirouse V, Mukherjee A, Papadopoulo D, Perez F, Plessis A, Rosse C, Saule S, Stoppa-Lyonnet D, Vincent A, White M, Legrain P, Wojcik J, Camonis J, Daviet L.. Protein interaction mapping: a Drosophila case study. Genome Research 2005 : 15, 376-384.


Fouix S., Martin-Lanérée S., Morla L., Sanial M., Lamour-Isnard C., Plessis A. Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis. Genes to Cell 8: 897-911.


Monnier. V., S. Ho K. S., Sanial M., Scott M. P. and Plessis A. Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2. BMC Developmental Biology 2: 4


Monnier V., Dussillol F., Alves G., Lamour-Isnard C., and Plessis A. Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signalling pathway. Current Biology, 8: 583-586.

Therond P., Lamour-Isnard C., et Plessis A. Dissection moléculaire de la voie de transduction du signal Hedgehog. Médecine-Sciences 5; p 603-60.