Development, Signalling and Trafficking





Our work is at a point of overlap between developmental biology (the development of the wing in the fly, Drosophila melanogaster) and two major themes in cellular biology: signal transduction (of the morphogenic and oncogenic Hedgehog signal, HH) and intracellular trafficking of proteins. Our aim is to elucidate the mechanisms involved and to integrate these events in a cellular and developmental context.


Group Leader : Anne PLESSIS

Professor, University of Paris

+33 (0)157278044

anne.plessis (at)






Research Topics

Développement et évolution , Dynamique cellulaire et signalisation


Selected publications


Brigui AHofmann LArgüelles CSanial MHolmgren R and Plessis A.
Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases. Open Biol. 2015 Oct;5(10).

Bras S, Martin-Lannerée S, Gobert V, Augé B, Breig O, Sanial M, Yamaguchi M, Haenlin M, Plessis A, Waltzer L.. Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis. Proc Natl Acad Sci U S A2012 Mar 12.
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Farzan S. F., Ascano, A., Ogden S. K, Sanial M.Brigui A.Plessis A. and Robbins D. J. Costal2 Functions as a Microtubule-Dependent Motor in the Hedgehog Signal Transduction Pathway. Current Biology2008: 18,1-6.
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Claret S.Sanial M.,and Plessis A. Evidence for a novel positive feedback loop in the Hedgehog pathway: the seven transmembrane-domains protein Smoothened and the kinase Fused act on each other. Current Biology2007: 17, 1326-1333.
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Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V, Maire S, Brun C, Jacq B, Arpin M, Bellaiche Y, Bellusci S, Benaroch P, Bornens M, Chanet R, Chavrier P, Delattre O, Doye V, Fehon R, Faye G, Galli T, Girault JA, Goud B, de Gunzburg J, Johannes L, Junier MP, Mirouse V, Mukherjee A, Papadopoulo D, Perez F, Plessis A, Rosse C, Saule S, Stoppa-Lyonnet D, Vincent A, White M, Legrain P, Wojcik J, Camonis J, Daviet L.. Protein interaction mapping: a Drosophila case study. Genome Research2005: 15, 376-384.
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