Aurora A kinase activation: Different means to different ends.

Tavernier N, Sicheri F, Pintard L. J Cell Biol. 2021 Sep 6;220(9):e202106128. doi: 10.1083/jcb.202106128. Epub 2021 Jul 21. PMID: 34287649


A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics.

Knox J, Joly N, Linossi EM, Carmona-Negrón JA, Jura N, Pintard L, Zuercher W, Roy PJ. Sci Rep. 2021 Apr 28;11(1):9161. doi: 10.1038/s41598-021-88150-6. PMID: 33911106 Free PMC article.


Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.

Tavernier N, Thomas Y, Vigneron S, Maisonneuve P, Orlicky S, Mader P, Regmi SG, Van Hove L, Levinson NM, Gasmi-Seabrook G, Joly N, Poteau M, Velez-Aguilera G, Gavet O, Castro A, Dasso M, Lorca T, Sicheri F, Pintard L. Nat Commun. 2021 Mar 26;12(1):1899. doi: 10.1038/s41467-021-21922-w. PMID: 33771996


PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly.

Velez-Aguilera G, Nkombo Nkoula S, Ossareh-Nazari B, Link J, Paouneskou D, Van Hove L, Joly N, Tavernier N, Verbavatz JM, Jantsch V, Pintard L. Elife. 2020 Oct 8;9:e59510. doi: 10.7554/eLife.59510. PMID: 33030429 Free PMC article.


Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development.

Joly N, Beaumale E, Van Hove L, Martino L, Pintard L. J Cell Biol. 2020 Jun 1;219(6):e201912037. doi: 10.1083/jcb.201912037. PMID: 32412594


Mitotic Cell Division in Caenorhabditis elegans.

Pintard L, Bowerman B. Genetics. 2019 Jan;211(1):35-73. doi: 10.1534/genetics.118.301367. PMID: 30626640


A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key.

Pintard L, Archambault V. Open Biol. 2018 Aug;8(8):180114. doi: 10.1098/rsob.180114. PMID: 30135239


PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain.

Gutnik S, Thomas Y, Guo Y, Stoecklin J, Neagu A, Pintard L, Merlet J, Ciosk R. Biol Open. 2018 Jul 16;7(7):bio034066. doi: 10.1242/bio.034066. PMID: 30012553


Cyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry.

Vigneron S, Sundermann L, Labbé JC, Pintard L, Radulescu O, Castro A, Lorca T. Dev Cell. 2018 Jun 4;45(5):637-650.e7. doi: 10.1016/j.devcel.2018.05.005. PMID: 29870721


Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans.

Martino L, Morchoisne-Bolhy S, Cheerambathur DK, Van Hove L, Dumont J, Joly N, Desai A, Doye V, Pintard L. Dev Cell. 2017 Oct 23;43(2):157-171.e7. doi: 10.1016/j.devcel.2017.09.019.


A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.

Dickinson DJ, Schwager F, Pintard L, Gotta M, Goldstein B. Dev Cell. 2017 Aug 21;42(4):416-434.e11. doi: 10.1016/j.devcel.2017.07.024. PMID: 28829947


BORA-dependent PLK1 regulation: A new weapon for cancer therapy?

Cirillo L, Thomas Y, Pintard L, Gotta M. Mol Cell Oncol. 2016 Jun 27;3(5):e1199265. doi: 10.1080/23723556.2016.1199265. eCollection 2016. PMID: 27857970


Mitotic entry: The interplay between Cdk1, Plk1 and Bora.

Parrilla A, Cirillo L, Thomas Y, Gotta M, Pintard L, Santamaria A. Cell Cycle. 2016 Dec;15(23):3177-3182. doi: 10.1080/15384101.2016.1249544. Epub 2016 Nov 10. PMID: 27831827


Microtubule-severing activity of the AAA+ ATPase Katanin is essential for female meiotic spindle assembly.

Joly N, Martino L, Gigant E, Dumont J, Pintard L. Development. 2016 Oct 1;143(19):3604-3614. doi: 10.1242/dev.140830. Epub 2016 Aug 30. PMID: 27578779


RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans.

Ossareh-Nazari B, Katsiarimpa A, Merlet J, Pintard L. G3 (Bethesda). 2016 Oct 13;6(10):3431-3442. doi: 10.1534/g3.116.033043. PMID: 27543292


Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells.

Thomas Y, Cirillo L, Panbianco C, Martino L, Tavernier N, Schwager F, Van Hove L, Joly N, Santamaria A, Pintard L, Gotta M. Cell Rep. 2016 Apr 19;15(3):510-518. doi: 10.1016/j.celrep.2016.03.049. Epub 2016 Apr 7. PMID: 27068477


Cell cycle timing regulation during asynchronous divisions of the early C. elegans embryo.

Tavernier N, Labbé JC, Pintard L. Exp Cell Res. 2015 Oct 1;337(2):243-8. doi: 10.1016/j.yexcr.2015.07.022. Epub 2015 Jul 23. PMID: 26213213


Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora.

Tavernier N, Panbianco C, Gotta M, Pintard L. Cell Cycle. 2015 Aug 3;14(15):2394-8. doi: 10.1080/15384101.2015.1053673. Epub 2015 Jun 3. PMID: 26038951


Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos.

Tavernier N, Noatynska A, Panbianco C, Martino L, Van Hove L, Schwager F, Léger T, Gotta M, Pintard L. J Cell Biol. 2015 Mar 16;208(6):661-9. doi: 10.1083/jcb.201408064. Epub 2015 Mar 9. PMID: 25753036