Cellular Spatial Organization




Our team aims to understand the basis of cellular organization, by addressing questions including: How do cells determine their functional morphologies? How might they probe their own size and shape? How do these geometrical properties contribute to regulate cell division, growth and tissue architecture?


Group Leader: Nicolas MINC

Research Director  CNRS

+33 (0)157278052








Research Topics:


Biologie quantitative et modélisation , Développement et évolution , Dynamique cellulaire et signalisation , Dynamique du génome et des chromosomes, Pathologies moléculaires et cellulaires


Selected publications:


  1. Palenzuela H, Lacroix B, Sallé J, Minami K, Shima T, Jegou A, Romet-Lemonne# G and Minc# N (2020) “In Vitro Reconstitution of Dynein Force Exertion in a Bulk Viscous Medium” , Current Biology, 30, 1–7


  1. Davi V, Chevalier L, Guo H, Tanimoto H, Barrett K, Couturier E, Boudaoud# A, and Minc# N, (2019) “Systematic mapping of cell wall mechanics in the regulation of cell morphogenesis” , Proc. Natl. Acad. Sci. USA, 116(28):13833-13838


  1. Sallé J, Xie J, Ershov D, Lacassin M, Dmitrieff S and Minc N, (2019) “Asymmetric division through a reduction of microtubule centering forces” J Cell Biol. 218(3):771-782 .


  1. Tanimoto H, Sallé J, Dodin L and Minc N (2018) “Physical forces determining the persistency and centring precision of microtubule asters” Nature Physics, 114, 848–854.


  1. Davì V, Tanimoto H, Ershov D, Haupt A, De Belly H, Le Borgne R, Couturier E, Boudaoud# A and Minc# N., (2018) “Mechanosensation Dynamically Coordinates Polar Growth and Cell Wall Assembly to Promote Cell Survival” Developmental Cell, 45, 2, p170–182.


  1. Pierre A, Sallé J, Wühr M, Minc N., (2016) “Generic Theoretical Models to Predict Division Patterns of Cleaving Embryos.” Developmental Cell. 39(6):667-682


  1. Tanimoto H, Kimura A, Minc N (2016) “Shape-motion relationships of centering microtubule asters” J Cell Biol 212 (7): 777.


  1. Bonazzi* D, Haupt* A, Tanimoto H, Delacourt D, Salort D, Minc N, (2015) “Actin-based transport adpapts polarity domain size to local cellular curvature” Curr Biol 25(20):2677-83.


  1. Bonazzi* D, Julien* JD, Seddiki R, Romao M, Piel M, Boudaoud# A, Minc# N, (2014) “Symmetry breaking in spore germination relies on an interplay between polar cap stability and spore wall mechanics.” Developmental Cell, 28 (5):534-546


  1. Minc# N., Burgess, D. and Chang F. (2011), “Influence of cell geometry on division plane positioning” Cell., 144 (3): 414-426.