Membrane Trafficking, Ubiquitin and Signalling


  1. Kahlhofer J, Leon S, Teis D, Schmidt O. The alpha-arrestin family of ubiquitin ligase adaptors links metabolism with selective endocytosis. Biology of the cell 2021;113(4):183-219. Epub 2020/12/15. doi: 10.1111/boc.202000137. PubMed PMID: 33314196.
  2. Renz C, Albanese V, Troster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A, Leon S, Ulrich HD. Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting. J Cell Sci. 2020;133(10). doi: 10.1242/jcs.244566. PubMed PMID: 32265276.
  3. Le Boulch M, Brossard A, Le Dez G, Leon S, Rabut G. Sensitive detection of protein ubiquitylation using a protein fragment complementation assay. J Cell Sci. 2020;133(12):jcs.240093. doi: 10.1242/jcs.240093. PubMed PMID: 32409563.
  4. Laussel C, Leon S. Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms. Biochem Pharmacol. 2020;182:114213. doi: 10.1016/j.bcp.2020.114213. PubMed PMID: 32890467.
  5. Ivashov V, Zimmer J, Schwabl S, Kahlhofer J, Weys S, Gstir R, Jakschitz T, Kremser L, Bonn GK, Lindner H, Huber LA, Leon S, Schmidt O, Teis D. Complementary alpha-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids. eLife. 2020;9. doi: 10.7554/eLife.58246. PubMed PMID: 32744498.
  6. Defenouillėre Q, Verraes A, Laussel C, Friedrich A, Schacherer J, Leon S. The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose. Sci Signal. 2019;12(597):aaw8000. doi: 10.1126/scisignal.aaw8000. PubMed PMID: 31481524.
  7. Leon S, Teis D. Functional patchworking at the plasma membrane. EMBO J. 2018;37(16):e100144. doi: 10.15252/embj.2018100144. PubMed PMID: 30061314; PMCID: PMC6092615.
  8. Kazamia E, Sutak R, Paz-Yepes J, Dorrell RG, Vieira FRJ, Mach J, Morrissey J, Leon S, Lam F, Pelletier E, Camadro JM, Bowler C, Lesuisse E. Endocytosis-mediated siderophore uptake as a strategy for Fe acquisition in diatoms. Sci Adv. 2018;4(5):eaar4536. doi: 10.1126/sciadv.aar4536. PubMed PMID: 29774236; PMCID: PMC5955625.
  9. Hovsepian J, Albanese V, Becuwe M, Ivashov V, Teis D, Leon S. The yeast arrestin-related protein Bul1 is a novel actor of glucose-induced endocytosis. Mol Biol Cell. 2018;29(9):1012-20. doi: 10.1091/mbc.E17-07-0466. PubMed PMID: 29514933; PMCID: PMC5921569.
  10. Simonetti F, Candelli T, Leon S, Libri D, Rougemaille M. Ubiquitination-dependent control of sexual differentiation in fission yeast. eLife. 2017;6. Epub 2017/08/26. doi: 10.7554/eLife.28046. PubMed PMID: 28841135.
  11. Hovsepian J, Defenouillere Q, Albanese V, Vachova L, Garcia C, Palkova Z, Leon S. Multilevel regulation of an alpha-arrestin by glucose depletion controls hexose transporter endocytosis. J Cell Biol. 2017;216(6):1811-31. Epub 2017/05/05. doi: 10.1083/jcb.201610094. PubMed PMID: 28468835; PMCID: PMC5461024.
  12. Hovsepian J, Becuwe M, Kleifeld O, Glickman MH, Leon S. Studying Protein Ubiquitylation in Yeast. Methods Mol Biol. 2016;1449:117-42. doi: 10.1007/978-1-4939-3756-1_5. PubMed PMID: 27613031.
  13. Herrador A, Livas D, Soletto L, Becuwe M, Leon S, Vincent O. Casein kinase 1 controls the activation threshold of an alpha-arrestin by multisite phosphorylation of the interdomain hinge. Mol Biol Cell. 2015;26(11):2128-38. doi: 10.1091/mbc.E14-11-1552. PubMed PMID: 25851600; PMCID: 4472021.