Evolution and genetics




Our research focuses on the mutations responsible for evolutionary change. We use a combination of different approaches to identify the mutations responsible for evolutionary change and to reconstruct past evolutionary events. We hope that our work will provide new and rigorous data to better understand our evolution, past and future.


Group Leader : Virginie Courtier

Research Director CNRS

+33 (0)157278043




ORCID 0000-0002-9297-9230





Research Topics:


Biologie quantitative et modélisation , Développement et évolution , Dynamique cellulaire et signalisation , Dynamique du génome et des chromosomes, Pathologies moléculaires et cellulaires


Selected publications


van Helden, J., Butler, C. D., Achaz, G., Canard, B., Casane, D., Claverie, J. M., … & Halloy, J. (2021). An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2. The Lancet.    Featured in several newspapers including   il Fatto Quotidiano Daily Mail ThePrint   


Peluffo AE, Hamdani M, Vargas-Valderrama A, David JR, Mallard F, Graner F, Courtier-Orgogozo V. A morphological trait involved in reproductive isolation between Drosophila sister species is sensitive to temperature. Ecology and Evolution 11(12), 7492-7506. doi: 10.1002/ece3.7580 DRYAD Supp Data BioRxiv 


Borne, F., Prigent, S.R., Molet, M., Courtier-Orgogozo, V. (2021) Drosophila glue protects from predation. Proc. R. Soc. B. 288: 20210088. doi: 10.1098/rspb.2021.0088 DRYAD Supp Data  BioRxiv
Actualité CNRS


Lefèvre, B.M., Catté, D., Courtier-Orgogozo, V., Lang, M. (2021) Male genital lobe morphology affects the chance to copulate in Drosophila pacheaBMC Ecol Evo 21, 23. doi: 10.1186/s12862-021-01759-z PDF


Rode N, Courtier-Orgogozo V, Débarre F. (2020) Can a population targeted by a CRISPR-based homing gene drive be rescued? G3. 10 (9), 3403-3415. doi: 10.1534/g3.120.401484 BioRxiv


Courtier-Orgogozo V, Danchin A, Gouyon PH, Boëte C (2020) Evaluating the Probability of CRISPR-based Gene Drive Contaminating Another Species. Evolutionary Applications 00:1–18. doi: 10.1111/eva.12939 BioRxiv PDF



Borne F, Kovalev A, Gorb S, Courtier-Orgogozo V (2020) The glue produced by Drosophila melanogaster for pupa adhesion is universal. Journal of Experimental Biology 223: jeb220608 doi: 10.1242/jeb.220608 Published 23 April 2020. DRYAD BioRxiv Featured in “inside JEBPDF
Passion Entomologie


Courtier-Orgogozo V, Martin A (2020) The Coding Loci of Evolution and Domestication: Current Knowledge and Implications for Bio-Inspired Genome Editing. Journal of Experimental Biology 223: jeb208934. Published 7 February 2020. doi: 10.1242/jeb.208934  PDF  HAL


Prigent S, Lang M, Nagy O, Acurio A, Matamoro-Vidal A, Courtier-Orgogozo and David JR (2020) Field collections reveal that São Tomé is the Afrotropical island with the highest diversity of drosophilid flies (Diptera: Drosophilidae). Annales de la Société Entomologique de France. doi:10.1080/00379271.2019.1703814 PDF HAL


Courtier-Orgogozo V, Martin A, Arnoult L, Prigent S, Wiltgen S (2020) Gephebase, a Database of Genotype-Phenotype Relationships for natural and domesticated variation in Eukaryotes. Nucleic Acid Research 48(D1), D696-D703. doi:10.1093/nar/gkz796 PDF HAL BioRxiv


Gavin Rice, Jean R. David, Yoshitaka Kamimura, John P. Masly, Alistair P. Mcgregor, Olga Nagy, Stéphane Noselli, Maria Daniela Santos Nunes, Patrick O’Grady, Ernesto Sánchez-Herrero, Mark L. Siegal, Masanori J. Toda*, Mark Rebeiz*, Virginie Courtier-Orgogozo*, Amir Yassin* (*: corresponding authors) (2019). Revised nomenclature and atlas of the male terminalia of Drosophila melanogasterFly. doi:10.1080/19336934.2019.1653733 PDF HAL preprints