Microtubule regulation in multi-cellular animals

 

 

We want to gain a fundamental understanding of how microtubule nucleation is spatiotemporally regulated within the context of multi-cellular animals. We are particularly interested in how the mechanisms regulating microtubule formation and organisation vary between cell types.

 

Group Leader : Paul Conduit

Research Director CNRS

+33 (0)157278089

paul.conduit(at)ijm.fr

@PaulConduit

https://orcid.org/0000-0002-7822-1191

 

 

RESEARCHMEMBERSPUBLICATIONSNEWSJOB

 

Research topics

 

Biologie quantitative et modélisation, Développement et évolution, Dynamique cellulaire et signalisation, Pathologies moléculaires et cellulaires

 

Selected publications

 

Tovey CA, Tsuji C, Egerton A, Bernard F, Guichet A, de la Roche M, Conduit PT*. (2021). Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects. JCB. 10.1083/jcb.202010020.

 

Mukherjee A, Brooks P, Bernard F, Guichet A, Conduit PT*. (2020). Microtubules originate asymmetrically at the somatic Golgi and are guided via Kinesin2 to maintain polarity within neurons. eLife. 2020;9:e58943. [link]

 

Mukherjee A and Conduit PT*. (2019). γ-TuRCs (quick guide). Current Biology. [link]

 

Tovey CA, Tubman CE, Hamrud E, Zhu Z, Dyas AE, Butterfield AN, Fyfe A, Johnson E, Conduit PT*. (2018). γ-TuRC heterogeneity revealed by analysis of Mozart1. Current Biology 28, 2314-2323. [link]

 

Tovey CA and Conduit PT*. (2018). Microtubule nucleation by γ-tubulin complexes and beyond. Essays in Biochemistry. DOI: 10.1042/EBC20180028 [link]