Microtubule regulation in multi-cellular animals



We want to gain a fundamental understanding of how microtubule nucleation is spatiotemporally regulated within the context of multi-cellular animals. We are particularly interested in how the mechanisms regulating microtubule formation and organisation vary between cell types.


Group Leader : Paul Conduit

Research Director CNRS

+33 (0)157278089








Research topics


Biologie quantitative et modélisation, Développement et évolution, Dynamique cellulaire et signalisation, Pathologies moléculaires et cellulaires


Selected publications


Tovey CA, Tsuji C, Egerton A, Bernard F, Guichet A, de la Roche M, Conduit PT*. (2021). Auto-inhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects. JCB. 10.1083/jcb.202010020.


Mukherjee A, Brooks P, Bernard F, Guichet A, Conduit PT*. (2020). Microtubules originate asymmetrically at the somatic Golgi and are guided via Kinesin2 to maintain polarity within neurons. eLife. 2020;9:e58943. [link]


Mukherjee A and Conduit PT*. (2019). γ-TuRCs (quick guide). Current Biology. [link]


Tovey CA, Tubman CE, Hamrud E, Zhu Z, Dyas AE, Butterfield AN, Fyfe A, Johnson E, Conduit PT*. (2018). γ-TuRC heterogeneity revealed by analysis of Mozart1. Current Biology 28, 2314-2323. [link]


Tovey CA and Conduit PT*. (2018). Microtubule nucleation by γ-tubulin complexes and beyond. Essays in Biochemistry. DOI: 10.1042/EBC20180028 [link]