Regulation of Cell-Fate Specification in the Mouse

 

 

 

We are studying the role of a secreted protein, called NODAL, in the specification of cell lineages during embryogenesis. This has led us to study the role of this molecule in tumour progression too.

 

 

Group Leader : Jérôme COLLIGNON

Research Director, Inserm

+33 (0)157278108

jerome.collignon(at)ijm.fr

https://orcid.org/0000-0002-1212-4006

 

 

RESEARCHMEMBERSPUBLICATIONS

 

 

Research Topics:

 

Biologie quantitative et modélisation , Développement et évolution , Dynamique cellulaire et signalisation , Dynamique du génome et des chromosomes, Pathologies moléculaires et cellulaires

 

 

Selected publications:

 

Plouhinec JL, Vieira M, Simon G, Collignon J*, Sorre B*. (2020). Dissecting signalling hierarchies in the patterning of the mouse primitive streak using micro-patterned EpiLC colonies. BiorXiv. doi: https://doi.org/10.1101/2020.11.30.404418

 

Dutriaux Annie, Diazzi Serena, Caburet Sandrine, Bresesti Chiara, Hardouin Sylvie, Deshayes Frédérique, Collignon Jérôme*, Flagiello Domenico*. (2021). LADON, a natural antisense transcript of NODAL, promotes metastasis an invasive behaviour in melanoma cells. BioRxiv. doi: https://doi.org/10.1101/2020.04.09.032375

 

Souilhol C*, Perea-Gomez A*, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J and Cohen-Tannoudji M. (2015). Notch activation interferes with cell fate specification in the gastrulating mouse embryo. Development 142, 3649-3660.

 

Cajal M, Creuzet S, Papanayotou C, Sabéran-Djoneidi D, Chuva de Sousa Lopes SM, Zwijsen A, Collignon J and Camus A. (2014). A conserved role for non-neural ectoderm cells in early neural development. Development 141, 1-12.

 

Papanayotou C and Collignon J. (2014). Activin/Nodal signalling before implantation: setting the stage for embryo patterning. Phil. Trans. R. Soc. B 369: 20130539.

 

Papanayotou C, Benhaddou A, Camus A, Perea-Gomez A, Jouneau A, Mezger V, Langa F, Ott S, Sabéran-Djoneidi D, Collignon J. (2014). A novel Nodal enhancer dependent on pluripotency factors and Smad2/3 signaling conditions a regulatory switch during epiblast maturation. PLoS Biol 12(6): e1001890.

 

Cajal M, Lawson KA, Hill B, Moreau A, Rao J, Ross A, Collignon J, Camus A. (2012). Clonal and molecular analysis of the prospective anterior neural boundary in the mouse embryo. Development 139, 423-36.

 

Granier C*, Gurchenkov V*, Perea-Gomez A, Camus A, Ott S, Papanayotou C, Iranzo J, Moreau A, Reid J, Koentges G, Sabéran-Djoneidi D, Collignon J. (2011). Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo. Dev Biol 349, 350-62.

 

Camus A, Perea-Gomez A, Moreau A and Collignon J. (2006). Absence of Nodal signalling promotes precocious neural differentiation in the mouse embryo. Dev. Biol. 295, 743-55.

 

Perea-Gomez A, Camus A, Moreau A, Grieve K, Moneron G, Dubois A, Cibert C and Collignon J. (2004). Initiation of gastrulation in the mouse embryo is preceded by an apparent shift in the orientation of the anterior-posterior axis. Current Biology, 14, 197-207.