Mitochondria, Metals and Oxidative Stress
By studying the assimilation pathways of iron and its intracellular metabolism in a model organism, the yeast Saccharomyces cerevisiae, we can address some of the fundamental problems of biology whilst considering new applications within the field of therapeutics or furthering our knowledge and understanding of the molecular bases of human pathologies.
Group Leader : Jean-Michel Camadro
Research Director CNRS
Research Topics:
Biologie quantitative et modélisation , Développement et évolution , Dynamique cellulaire et signalisation , Dynamique du génome et des chromosomes, Pathologies moléculaires et cellulaires
Selected publications
Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton.
Botebol H, Lesuisse E, Šuták R, Six C, Lozano JC, Schatt P, Vergé V, Kirilovsky A, Morrissey J, Léger T, Camadro JM, Gueneugues A, Bowler C, Blain S, Bouget FY.
Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14652-7. Epub 2015 Nov 9.
Abstract
A novel protein, ubiquitous in marine phytoplankton, concentrates iron at the cell surface and facilitates uptake.
Morrissey J, Sutak R, Paz-Yepes J, Tanaka A, Moustafa A, Veluchamy A, Thomas Y, Botebol H, Bouget FY, McQuaid JB, Tirichine L, Allen AE, Lesuisse E, Bowler C.
Curr Biol. 2015 Feb 2;25(3):364-71. Epub 2014 Dec 31.
Abstract
The metacaspase (Mca1p) has a dual role in farnesol-induced apoptosis in Candida albicans.
Léger T, Garcia C, Ounissi M, Lelandais G, Camadro JM.
Mol Cell Proteomics. 2015 Jan;14(1):93-108. Epub 2014 Oct 27.
Abstract
Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicans.
Guedouari H, Gergondey R, Bourdais A, Vanparis O, Bulteau AL, Camadro JM, Auchère F.
Biochim Biophys Acta. 2014 Sep;1842(9):1855-69. Epub 2014 Jul 10.
Abstract
bPeaks: a bioinformatics tool to detect transcription factor binding sites from ChIPseq data in yeasts and other organisms with small genomes.
Merhej J, Frigo A, Le Crom S, Camadro JM, Devaux F, Lelandais G.
Yeast. 2014 Oct;31(10):375-91. Epub 2014 Jul 28.
Abstract
The basis for evolution of DNA-binding specificity of the Aft1 transcription factor in yeasts.
Gonçalves IR, Conde e Silva N, Garay CL, Lesuisse E, Camadro JM, Blaiseau PL.
Genetics. 2014 Jan;196(1):149-60. Epub 2013 Oct 30.
Abstract
