Dynamique de la chromatine

dans le développement des mammifères

 

 

DNA methylation is a stable epigenetic mark that is absolutely essential for proper mammalian development. In the Greenberg lab, the primary focus is understanding the various mechanisms and functions of DNA methylation in the context of development. We take a multidisciplinary approach, utilizing genetics, genomics, and biochemistry. We also strive to comprehend how DNA methylation interacts with other chromatin pathways to gain a holistic picture of chromatin-based gene regulation

 

Responsable : Maxim Greenberg

Directeur de Recherche CNRS

ORCiD: 0000-0001-9935-8763

Office: +33 (0) 1 57 27 81 20
Lab: +33 (0) 1 57 27 80 32

maxim.greenberg(at)ijm.fr

@maxvcg

https://www.maximgreenberglab.com/

 

 

RECHERCHEMEMBRESPUBLIS

 

Thèmes et Axes de recherche

 

Biologie quantitative et modélisation (Bioinformatics, Transcriptomics), Développement et évolution (Stem cells, Cell fate and differentiation), Dynamique du génome et des chromosomes (Epigenetics, Gene expression)

 

Sélection de publications

 

Greenberg M.V.C. (2021) Get Out and Stay Out: New Insights into DNA Methylation Reprogramming in Mammals. Front. Cell Dev. Biol. 8:629068

 

Greenberg M.V.C, Bourc’his D. (2019) The diverse roles of DNA methylation in mammalian development and disease. Nature Reviews Molecular Cell Biology 20:590-607

 

Greenberg M.V.C.†, Teissandier A., Walter, M., Noordermeer D., Bourc’his D†. (2019) Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. eLife 8:e44057

 

Greenberg M.V.C.*, Glaser J.*, Borsos M., El Marjou F., Walter M., Teissandier A., Bourc’his D. (2017) Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth. Nature Genet. 49:110-118

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Greenberg M.V.C., Bourc’his D. (2015) Cultural relativism: maintenance of genomic imprints in pluripotent stem cell culture systems. Curr. Op. Genet. & Dev. 31:42–49

 

Greenberg M.V.C.*, Deleris A.*, Hale C.J.*, Liu A., Feng S., Jacobsen S.E. (2013) Interplay between active chromatin marks and RNA-directed DNA methylation in Arabidopsis thalianaPLoS Genet. 9(11): e1003946, 1-11

 

Stroud H., Greenberg M.V.C., Feng S., Bernatavichute Y.V., Jacobsen S.E. (2013) Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome. Cell 152: 352-64

 

Ausin I.*, Greenberg M.V.C.*, Simanshu D.K.*, Hale C.J., Vashisht A.A., Simon S.A., Lee T., Feng S., Espanola S.D., Meyers B.C., Wohlschlegel J.A., Patel D.J., Jacobsen S.E. (2012) INVOLVED IN DE NOVO 2 containing complex involved in RNA-directed DNA methylation in ArabidopsisProc. Nat. Acad. Sci. U. S. A. 109: 8374-8381

Greenberg M.V.C., Ausin I., Chan S.W.L., Cokus S.J., Cuperus J.T., Feng S., Law J.A., Chu C., Pellegrini M., Carrington J.C., Jacobsen S.E. (2011) Identification of genes required for de novo DNA methylation in ArabidopsisEpigenetics6:344-354

 

Deleris A.*, Greenberg M.V.C.*, Ausin I., Law R.W.Y., Moissiard G., Schubert D., Jacobsen S.E. (2010) Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA Methylation. EMBO Rep.11: 950-955